Executive Director, Biometrics - CVRM

Executive Director, Biometrics – CVRM

The Opportunity

Are you an accomplished biometrics leader with a passion for applying quantitative science to the development of transformative medicines? Would you like to shape the strategy and execution of clinical development programs across one of AstraZeneca’s most important and fastest-growing Therapy Areas?

As Executive Director, Biometrics – CVRM, you will be a senior leader within the CVRM Development organization and a core member of the relevant CVRM leadership team. You will lead the biometrics strategy across a disease area franchise, providing scientific and strategic direction for Biometrics. You will be accountable for ensuring that robust, innovative and decision-relevant evidence is generated throughout the development lifecycle. Working across a global matrix, you will influence portfolio decisions, strengthen regulatory strategies, enable efficient delivery and build a high-performing biometrics organization equipped for the future.

Key Accountabilities

Lead and develop a global statistics organization comprising individual contributors and people leaders within a matrix environment. Establish a clear vision, priorities and operating model aligned with the CVRM development strategy.

Ensure that clinical development programs use appropriate statistical designs, data sources, analytical methods, tools and processes to address their objectives clearly and robustly. 

You will provide oversight for the quality and timeliness of Biometrics contributions to clinical development planning, study design, protocols, statistical analysis plans, clinical study reports, regulatory submissions and responses to health authorities.

A key part of the role will be ensuring that decision-makers understand both the expected value and the uncertainty associated with development and investment choices.

Work with CVRM and enterprise partners to identify and deliver measurable improvements in productivity, quality and speed. This will include supporting the responsible adoption of AI-enabled and generative AI tools for activities such as data analysis, statistical programming, document creation, submission preparation and knowledge retrieval.

Essential Qualifications and Experience

• MSc in Biostatistics, Statistics, Applied Mathematics or another relevant quantitative discipline.
• Extensive experience in the pharmaceutical, biotechnology or life sciences industry, with a strong understanding of the end-to-end drug development lifecycle in cardiovascular, renal, metabolic or related disease areas.
• Demonstrated expertise across multiple clinical development phases, ideally including large, complex and pivotal Phase III programs.
• Significant experience leading statistical and programming contribution across multiple clinical development programs in a global, matrixed organization.
• Strong understanding of statistical principles and regulatory expectations relevant to clinical trials, including estimates, multiplicity, missing data, interim analyses and adaptive designs.
• Experience leading organizational change, capability building, productivity initiatives or digital transformation.
• A strong external scientific network and evidence of contribution to professional, academic or cross-industry groups.
• Excellent written, verbal and presentation skills, with the confidence to engage senior leaders, governance bodies, regulators and external experts.

Desirable Experience

• Experience leading enterprise-wide or cross-Therapy Area initiatives involving AI, automation, operating-model transformation or productivity --improvement.

• PhD in Biostatistics, Statistics, Applied Mathematics or another relevant quantitative discipline.
• Experience applying or evaluating AI-enabled, machine-learning or generative AI approaches in clinical development, data analysis or scientific operations.
• Understanding of data integrity, clinical data standards and regulatory expectations, including CDISC standards.
• Experience with real-world evidence, digital health technologies, patient-generated data or novel clinical outcome assessments.
• Experience with portfolio strategy, business development, due diligence or in-licensing activities.
• Experience developing externalization models and managing strategic outsourcing collaborations.

Why AstraZeneca? We are changemakers on the world stage at an exciting frontier of medicine—backed by deep knowledge and experience in our field. We lead the way into the future with energy and drive, helping to transform healthcare and build pandemic preparedness to protect against future health crises.When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace, and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office—while respecting individual flexibility.This is a place for those who thrive on energy and pace. We seek the best data-driven solutions, using cutting-edge methodologies and models to drive scientific breakthroughs. We don't accept the status quo—we dig deep to see what the data is telling us. Join us in our unique and ambitious world.The annual base pay for this position ranges from $278,568.00 - $417,852.00. Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.

Date Posted

31-Aug-2026

Closing Date

15-Sep-2026

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.