Senior Full Stack Software Engineer (San Francisco)

Based in San Francisco, Arine is a rapidly growing healthcare technology and clinical services company with a mission to ensure individuals receive the safest and most effective treatments for their unique and evolving healthcare needs.

Frequently, medications cause more harm than good. Incorrect drugs and doses cost the U.S. healthcare system over $528 billion in waste, avoidable harm, and hospitalizations each year. Arine is redefining what excellent healthcare looks like by solving these issues through our software platform (SaaS). We combine cutting‑edge data science, machine learning, AI, and deep clinical expertise to introduce a patient‑centric view to medication management, and develop and deliver personalized care plans on a massive scale for patients and their care teams.

Arine is committed to improving the lives and health of complex patients that have an outsized impact on healthcare costs and have traditionally been difficult to identify and address. These patients face numerous challenges including complicated prescribing issues across multiple medications and providers, medication challenges with many chronic diseases, and patient issues with access to care. Backed by leading healthcare investors and collaborating with top healthcare organizations and providers, we deliver recommendations and facilitate clinical interventions that lead to significant, measurable health improvements for patients and cost savings for customers.

Why is Arine a Great Place to Work?

Outstanding Team and Culture – Our shared mission unites and motivates us to do our best work. We have a relentless passion and commitment to the innovation required to be the market leader in medication intelligence.

Making a Proven Difference in Healthcare – We are saving patient lives and enabling individuals to experience improved health outcomes, including significant reductions in hospitalizations and cost of care.

Market Opportunity – Arine is backed by leading healthcare investors and was founded to tackle one of the largest healthcare problems today. Non‑optimized medication therapies cost the U.S. $275,000 lives and $528 billion annually.

Dramatic Growth – Arine is managing more than 18 million lives across prominent health plans after only 4 years in the market, and was ranked 236 on the 2024 Inc. 5000 list and named the 5th fastest‑growing company in the AI category.

The Role

This role emphasizes bridging the gaps often found in full‑stack positions by integrating backend, frontend, and systems‑level knowledge. You will design and implement key features, optimize performance, and develop internal libraries to enhance tracing, logging, and security, with a strong focus on type safety, schema development, compliance, and frontend technologies.

What You’ll Be Doing

• Design and extend services supporting document generation workflows using ReportLab
• Architect and build scalable services using AWS Lambda, API Gateway, AppSync, and DynamoDB, ensuring integration across backend and frontend systems
• Contribute to React frontend development for portal products and internal administration tools, with state management using Redux Toolkit (RTK) Query
• Implement and enforce code quality and security standards, including static code analysis, dependency management, and compliance with SOC II, HIPAA, GDPR, OWASP, and NIST frameworks
• Build and maintain observability systems for logging, tracing, and monitoring to ensure reliability and performance
• Develop and manage infrastructure with AWS services, including S3, IAM, RDS, CloudFormation, SQS, SNS, and EventBridge, using AWS SAM and AWS CDK for consistent deployments
• Write unit, integration, and contract tests, manage API versioning and schema consistency, and contribute to paying down technical debt
• Collaborate with engineers, product managers, and stakeholders to deliver solutions, and mentor junior engineers on full‑stack development, security, and compliance best practices

Who You Are and What You Bring

Core Foundations

• Strong experience in Reac t frontend development with state management and API integration (RTK Query preferred)
• Strong foundation in HTML and XML with experience using templating languages such as Jinja2
• Understanding of letter and envelope typesetting, formatting, and standards

Document Generation

• First‑hand experience developing and abstracting document generation services with ReportLab
• Skilled in writing unit, integration, and contract tests with experience managing API versioning and schemas
• Skilled in observability practices, including tracing, logging, monitoring, and debugging distributed systems
• Proven track record in architecting distributed systems and designing scalable, high‑performance services
• Skilled in AWS Lambda Powertools for reusable patterns, configuration, validation, error handling, and metrics collection

Infrastructure & Systems

• Experienced with AWS services , including Lambda, API Gateway, AppSync, DynamoDB, S3, IAM, RDS, CloudFormation, SQS, SNS, and EventBridge, and with AWS SAM and AWS CDK
• Knowledgeable in systems‑level design, infrastructure, networking, performance tuning, and change management
• Experienced in building self‑service tools that empower teams and reduce operational overhead

Security & Compliance

• Experienced in handling sensitive data in secure environments with strong knowledge of encryption, access controls, and secure data transmission (HIPAA/HITECH, FedRAMP, GDPR)
• Experienced in compliance programs such as SOC II and security frameworks such as OWASP and NIST
• Meticulous attention to detail with the ability to own projects end‑to‑end, collaborate with stakeholders, and mentor junior engineers
• Comfortable in a fast‑paced environment with the ability to adapt to changing priorities
• Results‑oriented and able to deliver against strict deadlines
• A team player who can also work independently
• Passionate about continuous learning and improving team capabilities

Nice‑to‑Haves

• Experience with WeasyPrint as a transferable skill for document generation
• Experience with image, PDF, and text automation solutions such as ImageMagick and Poppler
• Experience with Python libraries such as FastAPI, Tornado, and Typer
• Experience with CI/CD tools and platforms such as Docker
• Experience with build systems like Spack and general software building and packaging
• Experience optimizing database design with indexes, queries, and aggregations
• Experience working with healthcare data or EHR systems

Remote Work Requirements

• An established private work area that ensures information privacy
• A stable high‑speed internet connection for remote work
• This role is remote, but you will be required to come to on‑site meetings multiple times per year. This may be in the interview process, onboarding, and team meetings

Joining Arine offers you a dynamic role and the opportunity to contribute to the company’s growth and shape its future. You’ll have unparalleled learning and growth prospects, collaborating closely with experienced clinicians, engineers, software architects, and digital health entrepreneurs.

The posted range represents the expected base salary range for this position and does not include any other potential components of the compensation package, benefits, or perks. Ultimately, the final pay decision will consider factors such as your experience, job level, location, and other relevant job‑related criteria. The base salary range for this position is: $160,000–$180,000/year.

Job Requirements

• Ability to pass a background check
• Must live in and be eligible to work in the United States

Information Security Roles and Responsibilities

All staff at Arine are expected to be part of its Information Security Management Program and undergo periodic training on Information Security Awareness and HIPAA guidelines. Each user is responsible to maintain a secure working environment and follow all policies and procedures. Upon hire, each person is assigned and must complete trainings before access is granted for their specific role within Arine.

Arine is an equal opportunity employer. We are committed to creating a diverse and inclusive workplace where all employees are treated with fairness and respect. We do not discriminate on the basis of race, ethnicity, color, religion, gender, sexual orientation, age, disability, or any other legally protected status. Our hiring decisions and employment practices are based solely on qualifications, merit, and business needs. We encourage individuals from all backgrounds to apply and join us in our mission.

Check our website at This is a unique opportunity to join a growing start‑up revolutionizing the healthcare industry!

Job Offers: Arine uses the arine.io domain and email addresses for all official communications. If you received communication from any other domain, please consider it spam.

Note to Recruitment Agencies: We appreciate your interest in finding talent for Arine, but please be advised that we do not accept unsolicited resumes from recruitment agencies. All resumes submitted to Arine without a prior written agreement in place will be considered property of Arine, and no fee will be paid in the event of a hire. Thank you for your understanding.