Principal Scientist/Associate Director, Proteomics (On-Site)

Neomorph is seeking an experienced and innovative Principal Scientist / Associate Director to lead and expand our proteomics and mass spectrometry capabilities to support our molecular glue targeted protein degradation platform and pipeline. This individual will play a central role in scaling high-quality quantitative proteomics workflows to support discovery and translational research efforts as the company grows. The successful candidate will combine deep technical expertise in modern LC-MS proteomics with a strong understanding of assay development, quantitative rigor, and platform growth. This role offers the opportunity to help shape Neomorph’s next-generation proteomics infrastructure, including new instrumentation, automated workflows, and future team growth, while partnering closely with teams across biology, translational sciences, chemistry, and computational biology. Key Responsibilities Lead the continued expansion and evolution of Neomorph’s mass spectrometry‑based proteomics capabilities in support of our targeted protein degradation platform and discovery pipeline Develop and scale advanced quantitative proteomics workflows with a focus on throughput, reproducibility, automation, and operational excellence Drive implementation of new technologies, instrumentation, and proteomics approaches to expand platform capabilities and capacity Partner cross‑functionally with biology, translational sciences, chemistry, and computational teams to support discovery and translational research efforts Contribute to scientific strategy, experimental design, data interpretation, and long‑term platform development Mentor junior scientists and contribute to the continued growth of Neomorph’s proteomics function Required Qualifications PhD in Proteomics, Biochemistry, Molecular/Cell Biology, or a related discipline and 8+ years of relevant experience (Principal Scientist), or 10+ years of relevant experience (Assoc Dir) Deep expertise in mass spectrometry‑based proteomics, including extensive hands‑on experience with quantitative LC‑MS/MS workflows and high‑resolution mass spectrometry instrumentation Demonstrated experience independently developing and implementing robust, reproducible, and scalable proteomics assays and workflows in biotech, pharmaceutical, or translational research environments Strong understanding of experimental design, data analysis, and interpretation of complex proteomics datasets Excellent communication, organizational, and scientific problem‑solving skills Preferred Qualifications Experience developing and applying DIA‑based proteomics workflows Experience with specialized proteomics approaches such as post‑translational modification (PTM) profiling, interaction proteomics, or other specialized mass spectrometry workflows Familiarity with laboratory automation, high‑throughput workflows, and strategies to increase proteomics platform capacity and scalability Experience with targeted mass spectrometry assay development for translational or clinical applications Experience supporting targeted protein degradation or broader drug discovery programs Prior experience contributing to proteomics platform expansion, instrumentation growth, or team development What we offer Industry competitive compensation Annual target bonus Stock options 401K plan Career advancement opportunities Monthly town halls to share business and scientific updates Work Hard, Stay Well Comprehensive medical, dental, and vision plans for employees and their dependents Health and Dependent Care FSA and HSA Plan with monthly Neomorph contribution Employee Assistance Program 10 holidays + Winter Shutdown + 3 weeks of vacation time with additional accruals after 2nd year of employment, separate sick leave. Supplemental pay for Pregnancy Disability Leave Paid Parental Leave for employees with a newborn child or a child placed with them for adoption or foster care Lifestyle Casual work environment Volunteer days off each year to spend time contributing to causes you care about Flexible work schedule Access to onsite gym Onsite space to store your bicycle (or surfboard) Have Fun! We believe in work/life balance and Fun is at the core of our Core Values. In addition to department and company happy hours, we have regular company‑wide and department lunches and social events (ie Padres games, summer picnic, holiday party, bring your kids to work day). About Us Neomorph is a venture‑backed biotechnology company solving critical problems in human health through the discovery and development of innovative new medicines against ‘undruggable targets’. Our team is comprised of industry leading experts in protein degradation and molecular glues who have a track record of ground‑breaking discoveries in the field. We are committed to leadership in advancing the science and technology of molecular glue drug discovery, while prosecuting a pipeline of projects through clinical development. Our patient‑first, science‑driven approach is complemented by our dedication to a supportive and collaborative work environment. Neomorph is headquartered in San Diego, California. Neomorph is committed to pursuing and hiring a diverse workforce and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of any characteristic protected by applicable federal, state or local law. #J-18808-Ljbffr