Associate Director of Pathology

divh2Associate Director of Pathology/h2pHeadquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. Were pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals./ppAt Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees./ppWith an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive./ppWere building on our rich history, and we believe our greatest achievements are ahead of us. If youre passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career!/ppAssociate Director of Pathology/ppIonis is seeking a talented and highly motivated Pathologist within the Preclinical Development Department to provide strategic scientific leadership in the assessment of nonclinical safety of candidate medicines. The Preclinical Development Department includes highly collaborative scientists who provide a supportive environment that fosters growth and learning. Key responsibilities include:/pulliConduct histopathology review of internal and outsourced non-GLP and GLP research, pharmacology, and toxicology studies and provide interpretation that integrates all study data/liliServe as nonclinical safety representative on cross-functional project teams based on interest/liliContribute to the design of non-GLP and GLP nonclinical studies/liliProvide strategic input on the nonclinical toxicology and regulatory approach for IND-enabling packages and for clinical stage programs/liliAuthor nonclinical sections of regulatory documents (e.g. IB, IND, NDA, DSUR, etc) and represent Ionis in meetings with regulatory authorities/liliAssess mechanism(s) of toxicity to determine clinical relevance and impact/liliCommunicate pathology and nonclinical safety findings, interpretation, and impact to teams and governance committees/liliRepresent Ionis externally (e.g. at scientific meetings and/or through participation in industry consortia, working groups, and/or professional societies)/liliPublish findings in high impact peer-reviewed journal/li/ulpRequirements:/pulliDVM (or equivalent)/liliPhD in pathology, toxicology, or related life sciences discipline/liliBoard-certification in anatomic pathology (e.g. ACVP, ECVP)/liliAt least 5 years of experience in toxicologic pathology of multiple species in the pharmaceutical or biotechnology field with a focus on IND-enabling packages and beyond/liliExperience with digital pathology and image analysis is a plus/liliExperience with regulatory submissions and interactions/liliDemonstrated strong decision-making and problem-solving skills/liliTeam player with proven interpersonal and communication skills/liliDedication to life-long learning and professional development/li/ul/div