Principal Scientist, In Vivo Pharmacology, Oncology

Our Discovery Quantitative Biosciences (QB) in vivo Pharmacology – Oncology team in Boston is searching for a collaborative and innovative Principal Scientist with a strong background in Oncology In Vivo Pharmacology. The successful candidate will be an experienced In Vivo cancer biologist who will direct oncology reverse‑translational activities while serving as a key intellectual contributor in the conception and execution of oncology drug discovery projects. The role will involve building alliances with Discovery Oncology teams at the Boston and South San Francisco sites, championing new technologies (e.g., spatial biology using novel multiplex immunohistochemistry capabilities), and interfacing with our global pharmacology network. The successful applicant will also collaborate with teams in different functional areas (e.g., Bioinformatics, Discovery Chemistry, and Discovery Biologics) in a highly matrixed system and with external partners. Responsibilities Perform experiments using preclinical species to support the discovery and clinical development of novel oncology compounds. Manage external studies at CROs and academic collaborators, including monitoring study execution and ensuring finalization of study reports within set timelines. Manage a group of in vivo scientists, providing guidance, mentorship, accountability, and professional development opportunities. Serve as a scientific leader in the Quantitative Biosciences (QB) department in Boston, partnering and aligning with our global, network‑wide organizational objectives, and ensuring that we remain at the forefront of drug discovery. Represent the QB/Pharmacology functional area at therapeutic area governance forums, program teams, due diligence exercises, and/or cross‑functional teams as needed. Foster a culture of innovation and continuous improvement within the QB/Pharmacology team, driving the development and adoption of new methodologies and technologies. Ensure compliance with company established practices and procedures, including laboratory notebooks, computer files, quality and regulatory guidelines, and safety standards. Education PhD in Oncology, Pharmacology, Biology, Pharmaceutical Sciences, Chemistry, Immunology, Biotechnology, Molecular and Cell Biology, or related STEM field with 7+ years of industry/biotech experience in oncology drug discovery, or an MS with 10+ years of experience, or a BS with 14+ years of experience. Required Skills Experience using preclinical models to evaluate the in‑vivo pharmacology of novel modality‑agnostic oncology drugs (small molecules, antibodies, ADCs, TCEs, etc.). Experience with multiplex spatial biology capabilities including, but not limited to, immunohistochemistry, imaging mass cytometry, and PhenoCycler‑Fusion. Proven managerial/supervisory experience with a track record of training, developing talent, and mentoring team members in the field of oncology/pharmacology and drug discovery. Proficiency in complex problem‑solving and the ability to influence strategy across organizational boundaries. Strong skills in strategic thinking, effective communication, collaboration, balanced risk‑taking, and a relentless pursuit of excellence. Cancer Research, Drug Discovery Process, Immunoassays, Immunohistochemistry, In‑Vivo Models, Leading Project Teams, Mass Spectrometry Imaging, Molecular Biology Techniques, Mouse Models, Multiplex Assays, Oncology, Pharmacokinetics, Pharmacology, Tumor Biology. Eligibility U.S. and Puerto Rico residents only. Candidates in San Francisco and Los Angeles may be considered under local fair‑chance ordinances. Equal Employment Opportunity Statement As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. Salary and Benefits Salary range: $176,200.00 – $277,300.00. The range is based on education, qualifications, certifications, experience, geographic location, government requirements, and business needs. The successful candidate will be eligible for an annual bonus and long‑term incentive, if applicable. Benefits include medical, dental, vision, retirement (401(k)), paid holidays, vacation, and compassionate and sick days. Additional Details Employee Status: Regular Relocation: Domestic Visa Sponsorship: Yes Travel Requirements: 25% Flexible Work Arrangements: Not Applicable Shift: Not Indicated Valid Driving License: No Hazardous Material(s): Standard lab reagents Requisition ID: R397349 Job Posting End Date 06/02/2026 #J-18808-Ljbffr