Research Fellow - Lab Medicine and Pathology

Why Mayo Clinic

Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and  comprehensive benefit plans – to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic.

Benefits Highlights

• Medical: Multiple plan options.
• Dental: Delta Dental or reimbursement account for flexible coverage.
• Vision: Affordable plan with national network.
• Pre-Tax Savings: HSA and FSAs for eligible expenses.
• Retirement: Competitive retirement package to secure your future.

The candidate will be working under the mentorship of Dr. Maia and Dr. Harrington in a joint project to define transcriptional dependencies associated with serous (p53 Aberrant) endometrial cancer.

Responsibilities:

• Cultivate mammalian cell cultures, primarily intestinal organoid/tumoroid models
• Derive and establish normal and cancer organoid lines frompatient samples
• Design and conduct drug screenings and evaluate the efficacy of novel therapeutics in preclinical organoid models.
• Use reporter expressing organoid models to assess cell state dynamics, in response to various compounds and drug candidates, using flow cytometry analysis.
• Conduct a wide range of molecular biology techniques, such as DNA/RNA extraction, PCR, qPCR, cloning, western blotting and chromatin immunoprecipitation (ChiP).
• Interpret, present, and document experiments based on generated data to investigators
• Maintain and report accurate records of data
• Experience with genomics techniques such as ATAC-seq, RNA-seq, ChiP-seq, CUT&RUN is preferred.
• Experience with in vivo preclinical models of oncology is also preferred.

• PhD in a relevant field (e.g., cancer biology, molecular biology, genetics, or related disciplines).
• Proficiency in a wide range of molecular biology techniques, including DNA/RNA extraction, PCR, qPCR, cloning, western blotting, chromatin immunoprecipitation (ChiP) and CUT&RUN.
• Proficiency in mammalian cell cultures—particularly organoids.
• Proficiency in bioinformatic analysis.
• Excellent organizational skills and attention to detail.
• Ability to work independently as well as collaboratively in a team-oriented environment.
• Effective communication and interpersonal skills.

Just as our reputation has spread beyond our Minnesota roots, so have our locations. Today, our employees are located at our three major campuses in Phoenix/Scottsdale, Arizona, Jacksonville, Florida, Rochester, Minnesota, and at Mayo Clinic Health System campuses throughout Midwestern communities, and at our international locations. Each Mayo Clinic location is a special place where our employees thrive in both their work and personal lives.  Learn more about what each unique Mayo Clinic campus has to offer, and where your best fit is.

Equal Opportunity

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, protected veteran status or disability status. Learn more about the "EOE is the Law" .  Mayo Clinic participates in  E-Verify and may provide the Social Security Administration and, if necessary, the Department of Homeland Security with information from each new employee's Form I-9 to confirm work authorization.