Research Associate I - Brain Proteome Organization

Research Associate I – Brain Proteome Organization

The Allen Institute accelerates science for a healthier world through large-scale research designed to answer some of the most complex questions in biology. Our multi-disciplinary teams generate foundational knowledge, tools, and data to understand how our brain, cells, and immune system work. We share our work openly so others can build on it, move faster, and ask bigger questions. We drive discovery forward and create new possibilities for improving human health.

The goal of the Brain Science accelerator is to produce three interlocking resources: cell type atlases that catalog every kind of brain cell across ages and species, connectomes that chart the brain's intricate wiring, and a knowledge platform that knits it all together with powerful analysis tools. Every dataset is freely shared, so discoveries made here fuel discoveries everywhere.

We are seeking a Research Associate I to join a research team focused on understanding how the proteome of neuronal populations and their synapses shapes brain circuit function. Led by Marc van Oostrum, the team develops scalable synapse proteomics and systems-level analysis approaches to understand how the proteome and protein interactions determine synapse-type specific physiology and circuit connectivity.

The Research Associate will contribute to large-scale experimental workflows focused on molecular profiling of defined neuronal populations and synapse types in the mouse brain. The ideal candidate will be highly organized, detail-oriented, and excited to work in a collaborative, multidisciplinary environment. This position offers the opportunity to contribute to the development of next-generation experimental workflows and large-scale datasets in a team-oriented research environment.

At the Allen Institute, we believe that science is for everyone – and should be open to everyone. We are dedicated to combating biases and reducing barriers to STEM careers more broadly.

We also believe that science is better when it includes different perspectives and voices. We strive to make the Allen Institute a place where everyone feels like they belong and are empowered to do their best work in a supportive environment.

We are an equal-opportunity employer and strongly encourage people from all backgrounds to apply for our open positions.

Essential Functions

• Perform tissue dissections and biochemical preparation of mouse brain samples for downstream molecular profiling and imaging workflows
• Execute experimental workflows for synapse isolation, fluorescence-based sorting, and proteomic sample preparation
• Execute histology, fluorescence imaging, and tissue processing workflows
• Support molecular biology and viral vector preparation workflows
• Maintain accurate laboratory documentation and experimental records using established methods
• Contribute to optimization, troubleshooting, and quality control of experimental workflows
• Coordinate with internal teams and core facilities to support large-scale data and sample generation
• Present results and summarize experimental progress within the team
• Follow SOPs, good laboratory practices, and regulatory requirements

Required Education and Experience

• Bachelor's degree in neuroscience, biology, biochemistry, molecular biology, chemistry or related field

Preferred Education and Experience

• Experience in one or more of the following: molecular biology or biochemistry, mass spectrometry-based proteomics, mouse tissue processing and histology, microscopy, flow cytometry, automation of experimental workflows, or related experimental disciplines
• Ability to work independently and within a collaborative, multi-disciplinary environment
• Excellent organizational and communication skills
• Positive attitude, self-starter, demonstrated attention to detail, and enthusiasm for learning new experimental approaches

Work Environment

• Exposure to and handling of laboratory animals
• Laboratory environment - possible chemical, biological, or other hazardous substances exposure
• Possible exposure to BioSafety Level 2 organisms, such as recombinant viruses

Animal Care Services

• Exposure to and handling of laboratory animals required

Physical Demands

• Occasional lifting up to 30 pounds
• Fine motor movements in fingers/hands to operate computers and other office equipment; repetitive motion with lab equipment
• Stooping, bending, crouching

Position Type/Expected Hours of Work

• Occasional evening and weekend hours required
• This role is currently working onsite and is expected to work onsite for the majority of working hours. The primary work location for this role is 615 Westlake Ave N., with the flexibility to work remotely on a limited basis.

Travel

• Occasional travel to partner sites for compliance oversight required
• Occasional attendance and participation in national and international conferences may be required

Additional Eligibility Qualifications

• All employees who work with live animals must complete an Occupational Health medical history form and/or consultation with an Occupational Health Provider and receive clearance to work with animals. Depending on your health history and job responsibilities, an annual respiratory health screening and clearance to use a respirator may also be required.

Additional Comments

• Please note, this opportunity does not sponsor work visas
• Please note, this opportunity does not offer relocation funding

Annualized Salary Range

• $54,250- $66,450*

* Final salary depends on the required education for the role, experience, level of skills relevant to the role, and work location, where applicable.

Benefits

• Employees (and their families) are eligible to enroll in benefits per eligibility rules outlined in the Allen Institute's Benefits Guide. These benefits include medical, dental, vision, and basic life insurance. Employees are also eligible to enroll in the Allen Institute's 401k plan. Paid time off is also available as outlined in the Allen Institutes Benefits Guide.