Postdoctoral Scholar

Postdoctoral Scholar Location: Portland, Oregon Requisition ID: 2026-40496 • Position Category: Postdoctoral • Job Type: Postdoctoral • Posting Department: Chemical Physiology & Biochemistry • Posting Salary Range: $66,932 - $81,282 per year, with offer based on experience, education and internal equity • Posting FTE: 1.00 • Posting Schedule: Monday - Friday; occasional evenings and weekends as needed • Posting Hours: Varies; typically 9:00am - 5:30pm • HR Mission: School of Medicine • Drug Testable: No Department Overview This posting is for a Post-Doctoral Research Fellowship focused on the structure and function of membrane proteins, with an emphasis on ligand-gated ion channels. The successful candidate will contribute to studies aimed at understanding the molecular mechanisms underlying ion channel function, gating, and pharmacology through an integrated combination of biochemical, functional, and structural approaches. The Mansoor Lab studies the molecular structure and function of ion channels and receptors, with the broader goal of understanding fundamental mechanisms of membrane protein function and leveraging these insights toward the development of novel pharmacological approaches. Typical techniques and experiments in the lab include, but are not limited to, molecular biology, mammalian tissue culture, heterologous protein expression, membrane protein expression and purification, electrophysiology, and high-resolution structural biology. Applicants should have prior experience with protein expression and purification and be comfortable working with membrane proteins for structure-function studies. Experience with mammalian tissue culture and heterologous mammalian expression systems is highly desirable. Experience studying ligand-gated ion channels, including familiarity with two-electrode voltage clamp (TEVC) and/or whole-cell patch-clamp electrophysiology, is also desirable. Previous experience with high-resolution structural biology techniques, such as X-ray crystallography and/or single-particle cryo-electron microscopy, is preferred. Function/Duties of Position Primary Research (including planning, granting, execution, analysis, publication). Maintain laboratory compliance documentation for human, animal, biologicaland radiological work. Be familiar with lab safety infrastructure and ensure compliance with all safety regulations. Interact with biosafety, chemical safety, and safety officers on behalf of thePrincipal Investigator. Generate data and research analysis for investigator's use in preparation oftechnical reports and publications. Assist the PI with manuscript preparation and grant applications. Present, or assist in the presentation of, research projects at retreats, seminars,conferences and other OHSU or public venues. Providing training to users on lab practices and protocols, including samplepreparation and instrumentation use. Maintain an accurate and detailed laboratory notebook of all experimentsperformed. Participate in lab meeting. Training of lab personnel and supervision of Research Assistants, students andother lab members. Perform routine lab operations, including but not limited to the purchase oflaboratory supplies, monitoring supplies and maintaining all laboratoryequipment. Other duties as assigned. Required Qualifications Ph.D. in biological sciences. Experience purifying membrane proteins. Experience with heterologous mammalian expression systems. Some structural biology experience(preferably cryo-EM). Experience with model building. Skills and Abilities Experimental design andinterpretation of results. Basic molecular biological methods ofDNA manipulation and analysis. Knowledge of membrane proteinbiochemistry. Experience with cryo-EM dataprocessing and model building. Basic protein analysis techniques suchas western blots, immunoprecipitationand immunostaining skills, mammaliancell culture. Strong organizational and interpersonal skills. Strong scientific curiosity, problemsolvingskills and research integrity. High attention to detail and accuracy. Demonstrated success workingindependently and as amember of acollaborative team. Ability to communicate effectively, inboth written and oral formats. Working knowledge of office computerapplications, such as Word, Excel andPowerPoint. Preferred Qualifications Ph.D. in electrophysiology orBiochemistry. Experience purifying membraneproteins. Independent graduate-levelresearch in the electrophysiologyof ligand-gated ion channels. Experience with TEVCand/or whole cell patch clamp systems. Programming using Unix. Knowledge of membraneprotein biochemistry. Two electrode voltageclamp (TEVC) experiments. Whole cell patch clampexperiments. Additional Details Position is located at the OHSU Marquam Hill campus in Portland, Oregon. The work schedulewill be set by the supervising faculty, dictated by the needs of the research and planned experiments.Working evenings, weekends and extended hours may be required depending on the needs of theresearch. Work environment is in an open wet lab, in the presence of laboratory chemicals andautomated equipment. PI286706471 #J-18808-Ljbffr