Director, Computational Chemistry

Who we are:

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit  or follow us on  X (formerly Twitter)or  LinkedIn . 

How we work:

• PIONEER : We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.
• COLLABORATE : We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.
• BELONG : We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.

How you’ll make an impact:

• In close collaboration with medicinal chemists and project teams, apply a wide variety of drug-design and computational chemistry methods towards hit-finding, optimization of potency, selectivity, and ADME/Tox properties
• Assimilate, summarize, and apply SAR understanding by leveraging physics-based and data-driven modeling technologies to address discovery challenges.
• Develop, deploy, and expand internal AI/ML capabilities.
• As part of Design Teams and Project Teams, contribute to project strategies

Skills and experience you’ll bring:

• PhD, or equivalent, in the field of chemistry or computational chemistry with 8+ years of experience working in small-molecule drug discovery teams in a pharma or biotech setting.
• Strong external reputation with a track record of peer-reviewed publications of applying computational chemistry to drive drug discovery projects from target identification to development candidates
• Strong track record of successfully applying computational approaches, including but not limited to SBDD/FBDD, pharmacophore development, data analytics, virtual screening, machine-learning, and molecular dynamics studies to impacting drug discovery.
• Comprehensive understanding of modern drug discovery including target identification, hit finding, Biology, Medicinal Chemistry, and DMPK principles.
• Ability to independently solve problems, to think critically and creatively as part of a fast-paced and multidisciplinary team. Ability to help lead, recruit and cultivate a high performing team.
• Experience with CADD software such as Schrodinger, MOE, and proficiency coding in Python.
• Excellent organizational skills and ability to multi-task in an extremely fast-paced environment.
• Ability to communicate clearly and concisely with all stakeholders.
• Goal-driven, operates with a sense of urgency, highly collaborative, open-minded, data-driven, and creative.
• Persistent in the face of obstacles and uncertainty, flexible, self-aware of strengths and weaknesses, direct objectivity in the evaluation of data, and strongly optimistic about overcoming challenges. 

Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment.  All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.