Principal Scientist, Protein Engineering Display Technologies

**Working with Us** Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us . **Position Summary** We are seeking an enthusiastic, creative, and versatile Principal Scientist to join our collaborative Protein Engineering team in Redwood City/Brisbane (CA) to discover and engineer innovative biotherapeutic candidates and drive technological innovation. Our group acts on new ideas in the laboratory and thrives on the design-build-test cycle. You will solve complex protein engineering problems and implement robust platforms for protein therapeutic optimization. You will collaborate with talented colleagues across biotherapeutics and multiple therapeutic areas, and further support AI/ML workflows. You will present at internal and external meetings, contribute to therapeutic pipeline projects, publications, and patents. Responsibilities include selection-based assays using protein display library technologies, binder engineering for antibody-target interaction, cross-function and cross-site collaboration, and project and team management. **Responsibilities** + Lead yeast display team responsible for lead optimization of therapeutic proteins + Manage protein engineering/lead optimization pipeline and supervise laboratory scientists + Drive efforts to engineer antibodies, multispecifics, and alternative biologic formats for optimal therapeutic performance + Perform selections on yeast display libraries + Library design in collaboration with AI/ML engineers, library construction, NGS + Independently perform routine molecular biology techniques, DNA assembly and cloning, design expression constructs for external synthesis, and coordinate construct and library orders with CROs + Analyze library NGS data using no-code or low-code bioinformatics platforms + Independently perform complex experiments, troubleshoot, expertly analyze and interpret experimental results with strong attention to detail and documentation practices + Present results internally and externally, attend industry conferences + Accomplish goals under project team timelines **Basic Qualifications** + Bachelor's Degree with 9+ years of academic/industry experience, Master's Degree with 7+ years of academic/industry experience or PhD in Biochemistry, Bioengineering, Molecular Biology, or related fields with 5+ years of academic/industry experience **Preferred Qualifications** + PhD in Biochemistry, Bioengineering, Molecular Biology, or related fields with 5+ years of relevant post-graduate or biotech/biopharma industry experience related to antibody design and engineering + Expertise in molecular biology including DNA and RNA purification, cloning and DNA assembly, PCR, mutagenesis, plasmid/vector construction, vector elements, Sanger sequencing, NGS library preparation, etc. + Demonstrated experience in yeast display, antibody/protein library construction, sorting, analytical binding, etc. + Flow cytometry and FACS + In-depth understanding and experience in antibody engineering, including, but not limited to, affinity maturation, deep mutational scanning, species cross-reactivity, liability correction, biophysical/physiochemical property remediation, etc. + Sound understanding of proteins, antibodies, sequence, and structure-function relationships + Familiarity with biotherapeutics developability and manufacturability + Familiarity with protein structure analysis (Pymol, Chimera, MOE). + Familiarity with protein-protein interaction techniques and kinetics (BLI, SPR, on-cell binding) + Bioinformatics or data science experience is desirable (bash, Python, or R) + Proficiency with Microsoft Office suite, FlowJo, Prism, DNA cloning software + Managerial/supervisorial experience is required + Demonstrated experience in working in a cross-functional organization is required + Experience in lead discovery and optimization + Excellent written and oral communication skills If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career. **Uniquely Interesting Work, Life-changing Careers** With a single vision as inspiring as Transforming patients' lives through science , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues. **On-site Protocol** BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role: Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function. BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to View email address on de.jobsyn.org . Visit careers.bms.com/ ( eeo-accessibility to access our complete Equal Employment Opportunity statement. BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters. BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area. If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations. **Company:** Bristol-Myers Squibb **Req Number:** R1589694 **Updated:** 2025-07-15 01:48:41.806 UTC **Location:** Brisbane-CA Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.