Associate Director, Pharmacometrics, Clinical Pharmacology

Position Summary The individual will be responsible for the design, leadership, and implementation of Modeling & Simulation strategies across Travere clinical programs. In this role, you will perform or supervise execution of the pharmacometrics strategy in those programs, focusing on implementing model‑informed drug development (MIDD) approaches. You will set the strategy for addressing pharmacometric issues and directly influence drug development decisions. The successful candidate will have strong quantitative pharmacology skills, scientific reasoning, exploratory graphical analysis skills, and report‑writing skills. Responsibilities Developing and executing modeling and simulation strategies from the early through late‑stage clinical development and serving as the SME in cross‑functional development program teams Delivering strategic and well‑timed modeling input at key decision points along the development path Setting the strategy for addressing pharmacometric issues in regulatory submissions and directly influencing drug development decisions Leading and driving PMX contributions to integrate relevant technical and scientific knowledge in the planning and execution of robust quantitative development programs with a focus on MIDD strategies Using state‑of‑the‑art modeling and simulation approaches to interpret PK/PD data and ensuring appropriate PK‑PD analysis, including population PK, PK‑PD modeling and simulation, and exposure‑response analysis Guiding empirical modeling/QSP approaches to understand relationships between PK, biomarkers, and disease outcomes Education & Experience Requirements PhD or PharmD in Pharmaceutical sciences, Clinical Pharmacology, Mathematics, Statistics, Engineering (or equivalent) required 4+ years of relevant industry experience, including experience in NLME methods and its application in dose‑exposure‑response analysis, population PK/PD modeling, disease progression modeling, and clinical trial simulation Clinical pharmacology, statistics, and therapeutic knowledge in one or more disease areas Experience with incorporation of MIDD strategies into drug development across all phases and responding to questions on dose and regimen justification, study design, among others Hands‑on experience with at least NONMEM and R is strongly preferred Additional Skills, Experience & Requirements Embodies Travere’s core values: Courage, Community Spirit, Patient Focus, and Teamwork Well organized with the ability to multitask, prioritize, and manage shifting responsibilities in a small, fast‑moving, and entrepreneurial environment Ability to manage multiple, complex tasks with competing timelines Strong interpersonal, verbal, and written communication skills Driven, intelligent, passionate about making a difference for patients with rare diseases Self‑motivated and can independently manage responsibilities All positions require the ability to perform face‑to‑face work with colleagues and/or onsite in San Diego; no role is expected to be 100% remote Ability to travel Benefits Premium health coverage, financial, work‑life and well‑being offerings, wellness and employee support programs, life insurance, disability, retirement plans with employer match, and generous paid time off for eligible employees and dependents. Compensation Competitive compensation package including base pay and short‑term incentive, and long‑term incentive compensation (company stock). Target base pay range: $150,000.00 - $195,000.00. EEO Statement Travere Therapeutics, Inc. is an EEO/AA/Veteran/Disability Employer. #J-18808-Ljbffr