Senior/Principal Scientist, DEL Small Molecule Discovery
Lila Sciences
Lila Sciences in Cambridge, MA is looking for a Senior/Principal Scientist specializing in Small Molecule Therapeutics. This role focuses on leading hit identification through DNA-encoded libraries (DEL) and executing robust screening methodologies in collaboration with cross-functional teams. The ideal candidate should have a PhD and 6–8 years of experience in drug discovery, emphasizing assay development and the validation of resulting compounds. Attractive compensation, including equity, is offered for this innovative position. #J-18808-Ljbffr Lila Sciences
$168k - $252k
...agentic systems across drug discovery. Working at the intersection... ...scientifically rigorous AI co-scientists that enhance compound design... ...the primary focus will be small-molecule drug discovery, the successful... ..., data scientists, and senior leaders across a matrixed organization...PrincipalSeniorFull timeSummer workRemote workFlexible hours2 days per week3 days per week$146k - $236k
...user for the Applied AI and Engineering teams, feeding field discoveries back as product requirements. The role owns the credibility... ...development decisions Translational breadth across drug modalities (small molecule, biologic, gene therapy, novel platforms) Familiarity with...PrincipalSenior$146k - $236.5k
...company, is seeking a Sr. Scientist / Principal Scientist, Molecular Simulations... ...: Triage generated molecules before synthesis through a... ...least part of it in a drug discovery setting (Sr. Scientist); 6+... ...dynamics: force fields and small molecule parameterization (...PrincipalSenior$119.7k - $222.3k
...translation. Experience in late discovery into clinical development is... ...role potentially includes small molecules, biologics/therapeutic... ...strategy, to be considered for Principal Scientist II. 4+ years of experience to be considered for Senior Principal Scientist.Extensive...PrincipalSeniorFull time$121.28k - $202.13k
...clinical capabilities within GSK's new oligo synthesis lab. Areas of focus are producing small molecules, lipids, and linkers for ASOs, siRNA, SSO, and RNA editors conjugates, discovery chemistry, and method development. Your expertise will enable us to solve complex...PrincipalFull timeLocal area$138.6k - $257.4k
...a highly motivated and experienced scientist to lead a small group of biologists with advanced imaging... ...teams to enable complex target discovery and validation across disease areas.... ....Job DescriptionInternal Job Title: Senior Principal Scientist/Associate DirectorPosition...PrincipalSeniorFull time- ...Senior/Principal Scientist, MPN Biology, Translational Sciences PharmaEssentia Innovation Research... ..., cell-based therapies and small molecules. The successful candidate will contribute... ...from project conception to late discovery and into first in human clinical trials...PrincipalSeniorContract work
$120k - $180k
...Senior Scientist position focused on small molecule drug substance development at a pharmaceutical company. Responsibilities include managing technical transfers with contract manufacturers, conducting synthetic organic chemistry experiments across development stages,...SeniorContract work- Flagship Pioneering in Cambridge is seeking a Discovery Immunology Senior Scientist or Principal Scientist to develop first-in-class medicines. The ideal candidate will have expertise in disease biology, small molecule drug discovery, and functional assays. Responsibilities...Senior
$142.5k - $256.5k
...RoleModerna is seeking an accomplished and highly motivated Principal Scientist to join the Antibody Discovery team within Therapeutics Research. Therapeutics... ..., and optimizing antibody-based therapeutic molecules that enable new treatment strategies across Moderna'...PrincipalPermanent employmentFull timeWork from home$120k - $180k
Job DescriptionGeneral Summary:The MS&T Senior Scientist exercises a high level of experimental productivity contributing to the advancement of projects in pharmaceutical development or commercial manufacturing and may be running chemistry on multiple projects concurrently...SeniorFull timeSummer workFlexible hours$170k - $200k
...experience advancing discovery programs from hit identification... ...synthesizing complex molecules, peptides and... ...macrocyclic peptides and small molecule programs from... ...technologies (DEL, mRNA display , phage... ...and passionate team of scientists ~ Be a part of a cutting...Principal- ...level chemist to help establish pre‑clinical oligonucleotide conjugation capabilities for ASOs, siRNA, SSO, and RNA editors with small molecules, lipids, and linkers. The role covers method development from milligram to gram scale and requires leadership in cross‑...Principal
- ...94 is seeking an ambitious, creative, and talented Discovery Immunology Senior Scientist or Principal Scientist to join our research team. You will be part... ...of functional assays. A background in industrial small molecule drug discovery is a plus. Successful candidates will...Senior
- Moderna Therapeutics seeks a Senior Scientist for the Antibody Discovery team in Therapeutics Research. The role focuses on hands-on protein/antibody engineering... ...design teams to translate designs into testable molecules, driving iterative design-build-test-learn cycles in a...Senior
$117k - $201.25k
...Innovative Medicine (J&J IM) is recruiting for the role of "Principal Scientist - AI-Reasoning for Drug Discovery". The primary location for this role is Spring House... ...and production deployment The ability to lead small teams of researchers to achieve success in their...PrincipalLocal areaImmediate startWorldwideShift work$214.1k - $337k
Job DescriptionSenior Principal Scientist - Boston, MAOverviewWe are seeking a Senior Principal Scientist to provide scientific and strategic leadership for mass spectrometry-enabled discovery within the Quantitative Biosciences group in Boston. This role will help shape...PrincipalSeniorFull timeFor contractorsLocal area- UCB in Cambridge, MA is seeking a Senior Principal Scientist to lead translational biology drug discovery with emphasis on muscle biology. You will shape in vitro and in vivo models and develop cellular and biochemical assays for early programs across multiple neuromuscular...PrincipalSenior
$188k - $259k
About This Role Biogen is seeking a Sr. Principal Scientist, Oral Drug Product Development to... ...strategic leadership for the development of small molecule oral drug products. This role leads... ...The Sr. Principal Scientistserves as a senior drug product leader and mentor on...PrincipalSeniorFull timeTemporary workLocal area$138.6k - $257.4k
...Novartis Biomedical Research is seeking an accomplished Imaging Scientist to join the Image Analysis team in Cambridge.This role is for... ...microenvironment biologyExperience supporting oncology drug discovery or early clinical development with image-based biomarker strategies...PrincipalSeniorFull time$208k - $286k
...maintaining exploration of novel directions. We are looking for a Senior Principal Scientist to invent and build the next generation of evolutionary... ...learning, optimization, and automated scientific discovery. You will help define how AI systems navigate vast spaces...Principal- We are seeking a Senior Principal Scientist to join the US Neuromuscular group based in Cambridge, MA and help drive translational biology drug discovery efforts with an emphasis on muscle biology . This is an opportunity for a scientific leader to advance portfolio projects...PrincipalSeniorLocal area
$176.2k - $277.3k
...Metabolism and Bioanalytics - Principal ScientistOur company is a... ...and collaborative Principal Scientist (director-level equivalent)... ...contribute to our company’s drug discovery and early clinical... ...across multiple modalities (small molecules, peptides, protein therapeutics...PrincipalFull timeFor contractorsLocal areaWorldwideFlexible hours- Pioneering Intelligence is seeking a Senior Principal Scientist to invent and build the next generation of evolutionary algorithms for autonomous... ...on Bayesian inference, reinforcement learning, optimization, and automated discovery. #J-18808-Ljbffr Pioneering IntelligencePrincipal
$168k - $258.5k
...exciting mission: to unlock the future of small molecule drug discovery. FL129 is developing a revolutionary... ...and is recruiting a team of top-tier scientists to build this powerful and first-in-... ...a motivated and highly collaborative Senior Scientist to join FL129’s growing...Senior$180k - $258.5k
...Editing. At Expedition Medicines we create small molecules that edit protein structure and... ...molecule chemistry and chemoproteomic discovery technologies with Machine Learning (... ...seeking a motivated and innovative (Senior) Scientist, Machine Learning to join our team. In...Senior$108k - $128k
...Principal Associate Scientist Parabilis Medicines is a clinical-stage biopharmaceutical company... ...expertise. Experience in oncology drug discovery is strongly preferred. Familiarity... ...modalities beyond conventional small molecules is a plus. Strong organizational...PrincipalShift work$148.5k - $214.5k
Job title: Senior Principal Scientist Type 2 Immunology Location: Cambridge, MA About the Job Immunology and Inflammation Therapeutic Area We... ...reflect real-world needs. Work at the forefront of drug discovery, harnessing cutting-edge AI, data, and digital platforms to...PrincipalSenior- Johnson & Johnson is seeking a Principal Scientist, Animal Genetic Engineering - Antibody Discovery, to design and engineer mouse models for advanced antibody discovery. Based in Cambridge, MA or Spring House, PA, the role integrates mouse genetics, CRISPR, B cell immunology...Principal
$137k - $215.27k
...I submit in my employment application is true to the best of my knowledge.Job DescriptionAbout the role:The Pharmacovigilance Scientist, Senior Scientist ensures regulatory compliance and safety of Takeda's products by managing large projects, developing innovative solutions...PrincipalSeniorMinimum wageLocal area
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