Scientist II - Molecular and Proteomic Immunology

Scientist II – Molecular and Proteomic Immunology

The Allen Institute accelerates science for a healthier world through large-scale research designed to answer some of the most complex questions in biology. Our multi-disciplinary teams generate foundational knowledge, tools, and data to understand how our brain, cells, and immune system work. We share our work openly so others can build on it, move faster, and ask bigger questions. We drive discovery forward and create new possibilities for improving human health.

The goal of the Immunology accelerator is to create a deep, high-resolution reference for the human immune system in both health and disease, ultimately providing the data that will accelerate the development of diagnostics and therapies and serve as a hypothesis-generating sandbox for the entire scientific community.

We are searching for an exceptional molecular immunologist (Scientist II) to join a team focused on using and developing molecular and/or proteomic approaches to comprehensively study the interactions of the immune system. Specific responsibilities will include the design and development of new assays, technologies, and in vitro and ex vivo immunologic studies along with the analysis and synthesis of data generated through our cellular, molecular and proteomic platforms or their derivatives. A flexible and creative mindset along with the ability to function in a team to bring projects to completion on a timeline is essential.

The successful candidate will have a strong background in molecular and/or proteomic methodologies along with prior neuroscience and/or immunology experience. Strongest consideration will be given to candidates with a proven track record in identifying and progressing novel hypotheses forward in discovery research and technology development. This position is expected to last through December 2028 based on business needs and funding.

At the Allen Institute, we believe that science is for everyone – and should be open to everyone. We are dedicated to combating biases and reducing barriers to STEM careers more broadly.

We also believe that science is better when it includes different perspectives and voices. We strive to make the Allen Institute a place where everyone feels like they belong and are empowered to do their best work in a supportive environment.

We are an equal-opportunity employer and strongly encourage people from all backgrounds to apply for our open positions.

Essential Functions

• Support the development and application of molecular and proteomic technologies to drive biological insight in the context of immunology. Examples include spatial and droplet based NGS platforms such as Xenium and 10x FLEX or REFLEX
• Development of cellular engineering approaches for dissecting immune function. Examples could include molecular recorder systems and high throughput screens
• Design, execute and analyze in vitro and ex vivo immunological studies utilizing cell lines, primary cells, and tissues to develop and test hypothesis, possibly including the utilization of genetic mouse models
• Collaboration with a team to bring projects to completion on a timeline

Note: Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. This description reflects management’s assignment of essential functions; it does not proscribe or restrict the tasks that may be assigned.

Required Education and Experience

• Ph.D. or equivalent combination of degree and experience in a life sciences discipline
• 3+ years of postdoctoral experience

Preferred Education and Experience

• A strong background in molecular biology including NGS platforms
• Experience in cellular immunology
• Direct experience with advanced approaches in deconstructing immunologic mechanisms & testing hypotheses (e.g. targeted mutagenesis using CRISPR/Cas9, phenotypic screening, antibody-based immune modulation, lentiviral work, cell culture, etc.)
• Proven success in troubleshooting and innovation on existing platforms, including publications and/or patents
• Demonstrated ability to independently analyze data through coding languages (R, python, bash, version control)
• Exceptional oral and written communication skills and ability to effectively present complicated concepts internally and externally in a cross-discipline environment

Work Environment

• Working in a laboratory environment with potential exposure to lasers, biohazards

Physical Demands

• Occasional lifting to 30 pounds
• Fine motor movements in fingers/hands to operate computers and other office equipment; repetitive motion with lab equipment
• Stooping, bending, crouching

Position Type/Expected Hours of Work

• May need to work outside of standard working hours at times
• This role is currently working onsite and is expected to work onsite for the majority of working hours. The primary work location for this role is 615 Westlake Ave N., with flexibility to work remotely on a limited basis. We are a WashingtonState employer; any remote work must be performed in Washington State.
• This position is expected to last through December 2028, based on business needs and funding

Additional Eligibility Qualifications

• All employees who work with live animals must complete an Occupational Health medical history form and/or consultation with an Occupational Health Provider and receive clearance to work with animals. Depending on your health history and job responsibilities, an annual respiratory health screening and clearance to use a respirator may also be required.

Additional Comments

• **Please note, this opportunity may offer work visa sponsorship**
• **Please note, this opportunity may offer relocation assistance**

Annualized Salary Range

• $105,600 - $130,650 *

* Final salary depends on required education for the role, experience, and level of skills relevant to the role, along with work location, where applicable.

Benefits

• Employees (and their families) are eligible to enroll in benefits per eligibility rules outlined in the Allen Institute’s Benefits Guide. These benefits include medical, dental, vision, and basic life insurance. Employees are also eligible to enroll in the Allen Institute’s 401k plan. Paid time off is also available as outlined in the Allen Institute’s Benefits Guide. Details on the Allen Institute’s benefits offering are located at the following link to the Benefits Guide:

It is the policy of the Allen Institute to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by federal, state or local law. In addition, the Allen Institute will provide reasonable accommodations for qualified individuals with disabilities.