Principal Scientist II/Senior Principal Scientist, PK Sciences Clinical Pharmacology Artificial[...]

Job Overview:Hybrid location: Cambridge (USA). We are seeking an enthusiastic and motivated PK Sciences representative to lead the development and use of artificial intelligence (AI) enabled strategies to transform clinical pharmacology support of transformative new medicines. The successful candidate will offer insight into the development of AI‑based applications to support strategic, scientific and operational leadership and focus on enhancing the automation, innovation and acceleration of PKS/clinical pharmacology deliverables across the organization. Key Responsibilities Bring strong AI and digital fluency, using enterprise tools to further strategic, scientific and operational leadership in clinical pharmacology. Identify, develop and implement high‑value AI use cases that materially improve clinical pharmacology planning, analysis and decision quality. Represent the PK Sciences function in project teams, engaging stakeholders within the organization and with regulatory agencies. Proactively contribute to developing drug candidates across the research development and commercial continuum, providing expert pharmacokinetic, drug metabolism and clinical pharmacology input. Collaborate with teams to use AI to accelerate and enhance understanding of nonclinical and clinical PK/PD relationships, development dosing strategies and predictions. Champion the use of AI to accelerate and enhance the provision of dosage and PK/PD components of study protocols, reports, project summaries and development plans; author pharmacokinetic/clinical pharmacology/biopharmaceutics sections of IND/IMPD and NDA/BLAs and prepare responses to health authority questions. Drive close interdisciplinary collaboration among PK Science disciplines—Drug Disposition (ADME, BA), Modeling & Simulation (M&S)—through PK science sub‑teams. Work in close collaboration with clinicians and clinical development colleagues to integrate PKS insights into study design, data interpretation and project decision‑making. Model the use of artificial intelligence (AI)/machine learning (ML) approaches to enable model‑guided molecular design, preclinical and clinical data automation and regulatory document authoring. Essential Requirements Ph.D. / Pharm.D. with relevant experience in clinical pharmacology, drug metabolism and pharmacokinetics or a related background. Minimum 0-2 years of experience in drug discovery and/or development in a relevant environment (academia, CRO, biotech or pharma). 2+ years of experience preferably in a lead role overseeing ADME/DMPK project strategy in clinical development, or in AI strategy; eligible for Principal Scientist II. 4+ years of experience to be considered for Senior Principal Scientist. Extensive and in‑depth knowledge of pharmacokinetics, including drug metabolism and PK/PD evaluation. Experience working in project teams (preferably global) and sound awareness of recent developments in drug development and regulatory sciences. Exposure to working in a cross‑functional, matrixed, project‑team environment. Strong oral and written communication skills. Desirable Requirements Hands‑on project experience with artificial intelligence (AI) approaches and examples of applying AI to clinical pharmacology topics. Salary & Benefits Salary ranges:Principal Scientist II: $119,700 - $222,300 per year.Senior Principal Scientist: $138,600 - $257,400 per year.Final salary offered is determined based on relevant skills and experience and may be reviewed periodically upon joining. Compensation includes a performance‑based cash incentive and, depending on the level, eligibility for annual equity awards. U.S. based employees receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a generous time‑off package. Accessibility & Reasonable Accommodations Novartis is committed to working with individuals with disabilities. If you need a reasonable accommodation at any stage of the application process or to perform the essential functions of the position, please email View email address on click.appcast.io or call View phone number on click.appcast.io and provide the job requisition number. EEO Statement The Novartis Group of Companies is an equal opportunity employer. We do not discriminate in recruitment, hiring, training, promotion or other employment practices on the basis of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. #J-18808-Ljbffr U175 (FCRS = US175) Novartis Institutes for BioMedical Research, Inc.