Senior Scientist I, siRNA Pipeline Development & Targeted Delivery

Position Overview Senior Scientist I – siRNA group, Biotherapeutics & Genetic Medicine (BGM) department. Design and execute innovative experimental approaches to advance RNA-based therapies, including new therapeutic targets and delivery platforms. Responsibilities Lead research efforts within a cross‑functional team to advance new therapeutic targets for siRNA‑based pipeline development. Design and execute in vitro and in vivo proof‑of‑concept studies to evaluate novel extrahepatic, targeted siRNA delivery platforms across multiple pipeline programs. Design and execute receptor expression profiling, ligand‑receptor binding, internalization, and trafficking assays. Evaluate functional delivery and target knockdown in receptor‑positive cells and tissues. Provide scientific leadership and expertise in candidate nomination and pipeline development. Work independently and maintain a high level of productivity in the laboratory, ensuring efficiency and scientific rigor. Analyze and interpret multidisciplinary data to generate actionable conclusions and guide future experimental directions. Collaborate and effectively communicate results with key stakeholders and cross‑functional teams throughout the organization. Contribute as a primary author to scientific publications, presentations, and/or as a primary inventor of patent applications. Mentor and support junior scientists within the team. Qualifications BS, MS, or PhD in chemistry, biology, biochemistry, pharmacology or related field; experience 10+ years (BS), 8+ years (MS), or 0-3 years (PhD). Demonstrated expertise in siRNA candidate nomination and pipeline development. Experience in drug delivery platforms, receptor biology and targeted delivery. Hands‑on experience with uptake, trafficking, and functional delivery assays. Extensive experience and techniques for molecular and RNA biology, including cell culture, RNA extraction, RNA quantification (RT‑PCR, qPCR, ddPCR), next‑generation sequencing (NGS) library preparation, protein assays (ELISA, Western blot, JESS), flow cytometry and other biomarker quantification. Experience in assay development and high‑throughput screening for siRNA target identification and validation, mechanism of action studies, biodistribution and biomarker analysis is a plus. Proven ability to develop, troubleshoot and refine assays to enhance sensitivity, reproducibility, and throughput. Highly self‑motivated and capable of thriving in a fast‑paced, collaborative team environment. Strong written and verbal communication skills, with experience contributing to technical reports, publications, or regulatory documentation. Benefits Compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting; actual compensation may vary. Comprehensive benefits package including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) for eligible employees. Eligible to participate in short‑term incentive programs. EEO Statement AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer / Veterans / Disabled. US & Puerto Rico only – to learn more, visit #J-18808-Ljbffr Initial Therapeutics, Inc.