Senior Medical Director, Clinical Development

Senior Medical Director, Clinical Development Location: Cambridge, Massachusetts Employment Type: Full-Time Position Overview This individual will serve as a senior study physician supporting the development of novel therapies for patients with solid tumors. The Senior Medical Director will provide medical leadership across global clinical trials, with a strong emphasis on hands‑on medical monitoring, patient safety, clinical data review, and cross‑functional study execution. The position is well suited to an oncologist with experience leading early‑ and late‑stage clinical studies who wants to remain closely involved in the scientific and medical aspects of clinical development. Experience in lung cancer, including small‑cell lung cancer, and antibody‑drug conjugates is highly desirable, although candidates with broader solid‑tumor expertise will also be considered. Responsibilities Serve as the medical lead and study physician for global oncology clinical trials. Provide hands‑on medical monitoring, including the review of patient eligibility, safety events, laboratory findings, dose modifications, protocol deviations, and patient‑level clinical data. Lead the ongoing assessment of emerging safety, efficacy, pharmacokinetic, and pharmacodynamic data. Collaborate closely with Clinical Operations, Biostatistics, Data Management, Regulatory Affairs, Pharmacovigilance, Translational Medicine, and Medical Writing. Contribute to clinical development plans, study concepts, protocols, informed consent documents, investigator brochures, clinical study reports, and regulatory submissions. Support study design, dose‑escalation and expansion strategies, and benefit‑risk assessments. Provide medical guidance to investigators, study sites, CROs, and internal clinical study teams. Lead or participate in safety review committees, data review meetings, investigator meetings, and program‑governance discussions. Develop productive relationships with investigators, key opinion leaders, cooperative groups, and external scientific experts. Support interactions with global health authorities, including the FDA and other regulatory agencies. Evaluate clinical data to identify meaningful trends, emerging risks, and opportunities to optimize development strategy. Contribute to publications, abstracts, scientific presentations, and the communication of clinical study results. Provide scientific and medical input into potential indications, combination strategies, and lifecycle‑development opportunities. Mentor clinical scientists and other members of the clinical development organization. Qualifications MD or equivalent medical degree required. Board certification or board eligibility in Medical Oncology, Hematology/Oncology, or a related specialty strongly preferred. Approximately five or more years of clinical development experience within a biotechnology, pharmaceutical, or related research organization. Demonstrated experience serving as a study physician or medical monitor for interventional oncology clinical trials. Strong knowledge of solid‑tumor drug development and contemporary oncology clinical practice. Experience reviewing patient‑level safety and efficacy data and making timely medical decisions. Experience contributing to clinical protocols, development plans, regulatory documents, and health‑authority interactions. Ability to operate effectively across global, multidisciplinary clinical development teams. Strong written, verbal, presentation, and relationship‑management skills. Sound clinical judgment and the ability to succeed in a fast‑paced, data‑driven environment. Required Skills Demonstrated experience serving as a study physician or medical monitor for interventional oncology clinical trials. Strong knowledge of solid‑tumor drug development and contemporary oncology clinical practice. Experience reviewing patient‑level safety and efficacy data and making timely medical decisions. Experience contributing to clinical protocols, development plans, regulatory documents, and health‑authority interactions. Ability to operate effectively across global, multidisciplinary clinical development teams. Strong written, verbal, presentation, and relationship‑management skills. Sound clinical judgment and the ability to succeed in a fast‑paced, data‑driven environment. Preferred Skills Clinical or drug‑development experience in lung cancer, particularly small‑cell lung cancer. Experience developing antibody‑drug conjugates or other targeted oncology therapies. Experience within global Ph3 studies Familiarity with global clinical programs conducted across the United States, Europe, and Asia. Experience supporting regulatory submissions or major clinical-development milestones. #J-18808-Ljbffr Meet Life Sciences Ltd.