Technical Development Principle Scientist

The PositionA healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That’s what makes us Genentech!In Pharma Technical Development (PTD), we actively collaborate and develop creative technical solutions to efficiently transform scientific ideas into products. Our mission is to reliably deliver the pipeline and supply quality products to patients. The group excels in its work through innovation, teamwork, dedication and mutual respect, and contributes every single day, continuously improving what it does.Our global Analytical Development and Quality Control (ADQC) organization is a leader in developing, validating and executing physicochemical, immunochemical, and biological methods for our biologics pipeline. This function provides integrated analytical control strategies and systems that enable CMC development of biologic therapeutics, process development, product characterization, and drug delivery for biologic products from research (molecular assessment) through post product launch.The OpportunityA Technical Development Principle Scientist position is available in the Analytical Development Department (within Pharma Technical Development organization). The selected candidate will participate as the analytical expert in a multi-disciplinary CMC (chemistry, manufacturing, and controls) team and will contribute to the development of several active clinical (phase 1-3) therapeutics simultaneously. The candidate will be responsible for designing and executing analytical studies that support process development and enable successful regulatory filings (IND, BLA). The successful candidate will have sound analytical chemistry fundamentals and an eagerness to flex between diverse analytical techniques including but not limited to high performance liquid chromatography, mass spectrometry, capillary electrophoresis, advanced spectroscopy.Who you areRequired QualificationsPh.D. (4-6 additional years experience), M.S./B.S. (6-10 additional years experience) in Analytical Chemistry, Biology, Biochemistry, Chemistry, Chemical Engineering or related disciplineSound fundamental knowledge in the analytical characterization of proteins or related therapeutic modalitiesWell-rounded practical experience in the application of high performance liquid chromatography, liquid chromatography-mass spectrometry, capillary electrophoresis, and advanced spectroscopy with at least one area of deep analytical expertiseKnowledgeable about CMC (chemistry, manufacturing, control) development from Phase I to commercial Self-motivated, have excellent organization, oral and written communication skills, and be willing to work both independently and as a team member. The candidate is expected to present data at internal and external meetings when appropriate. Willing to work in a dynamic, fast-paced environment, and be capable of driving tasks to completion in a timely fashion.Preferred QualificationsPrior experience with small molecule linker drugs and antibody-drug conjugates (ADCs)Prior experience supporting IND-enabling and BLA-enabling activitiesRelocation benefits are available for this job posting.The expected salary range for this position based on the primary location of South San Francisco, CA is $120,800 - $224,300. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.BenefitsGenentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.Job SummaryJob number: 202602-102809Date posted : 2026-02-11Profession: Manufacturing & EngineeringEmployment type: Full time