Bioinformatics Research Scientist (TIRTL Collaborative Center)

Position Overview The Tracking the Immune Repertoire of Tumor Lymphocytes (TIRTL) Bluesky program in the Host–Microbe Interactions Department at St. Jude supports multiple institutional research and clinical programs focused on immune repertoire profiling. Building on the foundational TIRTL‑seq (Pogorelyy and Kirk et al., Nature Methods 2025) method, the program provides cohort‑scale T cell and B cell receptor (TCR and BCR) sequencing, enabling research in cancer immunology, infectious disease, and antibody discovery across the institution. We are seeking a Bioinformatics Research Scientist to develop, maintain, and scale robust computational pipelines that support high‑throughput immune repertoire sequencing and antibody discovery across cancer and infectious disease programs. Job Responsibilities Independently perform basic and advanced statistical analysis, algorithm implementation, and programming from a variety of biotechnology platforms, and oversee quality checks. Design and prepare materials and courses for training on bioinformatics software, databases, computing, data mining, and analysis. Act as a liaison between end‑users, software developers, system designers, and different departments. Establish protocols or best practices for common research tasks and SOPs, evaluate products and solutions, make recommendations, and integrate solutions. Lead the development, implementation, installation, and maintenance of databases; coordinate data collection, database implementation, usage, and hardware/software related to database collection. Develop programs to assist in data analysis within the databases. Assist in planning, coordinating, and organizing projects across departments and delegate tasks based on priority, expertise, and capacity. Perform other duties as assigned to meet the goals and objectives of the department and institution. Maintain regular and predictable attendance. Develop and maintain bioinformatics pipelines for TCR and BCR repertoire sequencing. Perform and oversee data QC, statistical analysis, and interpret repertoire datasets. Integrate immune repertoire data with clinical metadata and other multi‑omics datasets. Document and maintain workflows and databases to ensure reproducibility, scalability, and long‑term data and code reuse. Support infectious disease and host–microbe interaction studies, with emphasis on B cell responses and antibody discovery. Support immuno‑oncology projects, including analysis of tumor‑infiltrating lymphocytes and integration with tumor genomic and clinical data. Collaborate with investigators and serve as a technical liaison between wet‑lab, clinical, and computational teams. Contribute to continuous improvement and expansion of TIRTL analytical capabilities. Preferred Skills Experience with immune repertoire analysis (BCR and/or TCR). Familiarity with tools and methods for BCR clonotyping, somatic hypermutation analysis, lineage reconstruction, or antigen‑driven selection. Background in cancer immunology, infectious disease, or antibody discovery. Experience with Linux, HPC environments, version control, and workflow systems. Minimum Education and Training Bachelor's degree in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry) or a related field. A Master's degree or PhD is preferred. Minimum Experience Minimum requirement: Bachelor's degree with 6+ years of relevant post‑degree work in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry). Experience exception: Master’s degree with 4+ years of relevant post‑degree experience, or PhD with no experience. Experience in at least one programming or scripting language and at least one statistical package; R is preferred. Significant experience in at least one programming or scripting language and at least one statistical package; Python/R preferred. Strong experience with high‑throughput sequencing data analysis. Compensation St. Jude is including a reasonable estimate of the compensation range for this role. A reasonable estimate of the current salary range is $86,320 – $154,960 per year for the Bioinformatics Research Scientist (TIRTL Collaborative Center). Legal Notice St. Jude is an Equal Opportunity Employer. St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email search firms; all resumes submitted by search firms to any employee or representative at St. Jude via email, the internet, or any other form will result in no fee being paid in the event the candidate is hired by St. Jude. #J-18808-Ljbffr