Principal Scientist
GSK LLP
GSK in Cambridge, MA is seeking a PhD-level chemist to help establish pre‑clinical oligonucleotide conjugation capabilities for ASOs, siRNA, SSO, and RNA editors with small molecules, lipids, and linkers. The role covers method development from milligram to gram scale and requires leadership in cross‑functional settings. You will design workflows, draft SOPs, and work with analytical teams to ensure high-quality conjugates while collaborating across teams to meet program milestones. #J-18808-Ljbffr GSK LLP
- ...MassachusettsCompany: Planet Pharma GroupContact: ApplicationsEmail: ****@*****.*** are seeking a highly skilled Scientist to join our Biologics Discovery team and lead antibody discovery efforts. We are looking for someone who thinks carefully about...Principal
$137k - $215.27k
...information I submit in my employment application is true to the best of my knowledge.Job DescriptionAbout the role:The Pharmacovigilance Scientist, Senior Scientist ensures regulatory compliance and safety of Takeda's products by managing large projects, developing innovative...PrincipalMinimum wageLocal area$160k - $235k
...Sr. Scientist/Principal Scientist, Translational Research and Clinical Biomarkers (Immunology) Boston, MA Salary Band: $160,000-$235,000 Location: Downtown Boston, MA Position Summary Antares Therapeutics is seeking to add an enthusiastic and highly motivated...Principal$115k - $215k
...quantitative proteomics data analysis tools.Domain leadership with cross-functional drug discovery:Highly organized, solutions-oriented scientist with the ability to manage multiple priorities simultaneously while driving innovation in targeted proteomics workflows and...Principal- ...development, scale‑up, and technology transfer for small molecule oral dosage forms across all development stages. You will mentor scientists, drive cross‑functional CMC/regulatory activities, and advance enabling formulation strategies to improve portfolio execution and...Principal
$146k - $236k
About Pioneering IntelligencePioneering Intelligence builds on Flagship Pioneering’s legacy of founding cutting-edge science and computational ventures, harnessing recent advances in AI, machine learning, and data to accelerate fundamental research and create a portfolio...Principal$148.5k - $214.5k
Job title: Senior Principal Scientist/Principal Scientist, Real-World Evidence & Disease GenomicsLocation: Cambridge, MAAbout the JobJoin Sanofi's Target, Disease and Systems Biology (TDSB) team and become a key contributor to our Disease Genetics and Genomics cluster....PrincipalFull time$168k - $252k
Job DescriptionVertex is seeking an accomplished Senior Principal Scientist with proven record of developing, testing and deploying scientific computational methods and agentic AI systems for drug discovery. In this role, you will work across modalities with emphasis on...PrincipalFull timeSummer workRemote workFlexible hours2 days per week3 days per week$214.1k - $337k
Job DescriptionSenior Principal Scientist - Boston, MAOverviewWe are seeking a Senior Principal Scientist to provide scientific and strategic leadership for mass spectrometry-enabled discovery within the Quantitative Biosciences group in Boston. This role will help shape...PrincipalFull timeFor contractorsLocal area$168k - $252k
...high-value opportunities across the design-make-test-analyze (DMTA) cycle and translate them into scientifically rigorous AI co-scientists that enhance compound design, knowledge synthesis, data interpretation, hypothesis generation, and decision-making. Although the...PrincipalFull timeSummer workRemote workFlexible hours2 days per week3 days per week- UCB in Cambridge, MA is seeking a Senior Principal Scientist to lead translational biology drug discovery with emphasis on muscle biology. You will shape in vitro and in vivo models and develop cellular and biochemical assays for early programs across multiple neuromuscular...Principal
$179k - $236k
...nonclinical and clinical programs, operating as a hands-on scientific leader. We are looking for an accomplished DMPK and bioanalytical scientist with experience in PK study design, bioanalytical method development, and translational biomarker strategy. This person will...Principal- ...Principal Scientist Our mission at Asimov is to advance humanity's ability to design living systems, enabling biotechnologies with outsized benefit to society. We're developing a mammalian synthetic biology platform––from cells to software––to enable the design and...Principal
$188k - $259k
...internal and external manufacturing sites. Provide strategic oversight and establish manufacturing strategies. Mentor and develop scientists and engineers supporting oral drug product development. Oversee completion of drug product sections for regulatory submissions...PrincipalFull timeTemporary workLocal area$198.9k - $269k
...range of science and engineering domains within Amazon, and you will join the team at the forefront of this research.As a Principal Applied Scientist, you will play a pivotal role in shaping the definition, vision, and development of product features from beginning to...PrincipalFlexible hours$119.7k - $222.3k
Job Description SummaryLocation: Cambridge MAInternal: Principal Scientist I/IILI#-HybridThe individual will provide scientific and operational support to Study Quality and Compliance group within the Toxicology line function of Preclinical Safety (PCS). Key areas of responsibility...PrincipalPermanent employmentFull time$126k - $234k
...of treatment approaches including targeted therapies, immunotherapies, CAR-T, and radioligand therapy. NIBR is seeking an in vivo scientist to join our Oncology Pharmacology team in Cambridge, MA. The successful candidate will join a dynamic, multi-disciplinary team and...PrincipalFull timeRemote work$147.2k - $220.8k
...therapeutics and other emerging modalities. The candidate will work closely with colleagues across Research and Development as a Principal Scientist within Drug Metabolism and Pharmacokinetics (DMPK), providing scientific leadership and strategic guidance to advance...PrincipalFull timeTemporary workWork at officeLocal areaFlexible hours$190.8k - $300.3k
Job DescriptionWe are seeking an accomplished and highly motivated Principal Scientist to provide strategic and scientific biomarker leadership across programs within the Cardiovascular & Metabolic and Infectious Diseases/Vaccines portfolios.This role will lead the design...PrincipalFull timeFor contractorsLocal areaFlexible hours$122.25k - $176.58k
Job Title: Principal Scientist, Systems and Disease BiologyLocation: Cambridge, MAAbout the JobAs a Principal Scientist within our Systems and Disease Biology Cluster, you will decode disease mechanisms at cellular resolution and pioneer AI-powered workflows that accelerate...PrincipalFull time$142.5k - $256.5k
..., as a shared discovery resource. This role is intended for a scientist ready to own and evolve a core discovery capability, led by scientific... ...independence, judgment, and ownership consistent with a Principal Scientist role.Here’s What You’ll Bring to the Table (...PrincipalPermanent employmentFull timeWork at officeWork from home$138.4k - $207.6k
Job DescriptionGeneral Summary:Vertex Pharmaceuticals is seeking a Principal Scientist, Microbiology to join the Analytical Science & Technology (AS&T) organization supporting biologics, cell therapy, and gene therapy programs. This role serves as the microbiology technical...PrincipalFull timeContract workSummer workRemote workFlexible hours2 days per week$142.5k - $256.5k
The RoleThe Therapeutics Research group at Moderna is seeking a talented, experienced, and highly motivated Principal Scientist to build, optimize, and execute T cell receptor optimization workflows for next-generation TCR-based therapeutics.This individual will lead the...PrincipalPermanent employmentFull timeWork at officeWork from home$119.7k - $222.3k
...preferably in a lead role overseeing ADME/DMPK project strategy in clinical development, or in AI strategy, to be considered for Principal Scientist II. 4+ years of experience to be considered for Senior Principal Scientist.Extensive and in-depth knowledge of...PrincipalFull time$216k - $297k
...reasoning efforts on both the technical and application levels. You will be a hands-on lead for a team of talented machine learning scientists innovating on model architectures that will create best-in-class biological reasoning engines. You will be responsible for...Principal$138k - $207k
Job DescriptionGeneral Summary:Vertex Pharmaceuticals is seeking a highly experienced and motivated Principal Scientist to join the Vertex Manufacturing Center (VMC) Kilo Lab in a dual-capability role that is central to our drug substance development mission. This is an...PrincipalFull timeSummer workFlexible hours$142.5k - $256.5k
The RoleModerna is seeking an accomplished and highly motivated Principal Scientist to join the Antibody Discovery team within Therapeutics Research. Therapeutics Research generates innovative therapeutic concepts and advances them from early scientific idea through First...PrincipalPermanent employmentFull timeWork at officeWork from home$169.8k - $355.4k
...particular business problems with our assistance and expertise. In this role, you will have an opportunity to work with teams of applied scientists and engineers to deliver high quality computer vision models and services that delights our customers with the confidence that...PrincipalTemporary workFlexible hours$208k - $286k
...elevating the AI advances happening across the ecosystem in human health, sustainability, and beyond. THE ROLE We are seeking a Principal Scientist (Embedded ML/Computational) to lead AI/ML and computational projects that accelerate pharmaceutical R&D across the...Principal$176.2k - $277.3k
...DescriptionBoston Pharmacokinetics, Dynamics, Metabolism and Bioanalytics - Principal ScientistOur company is a global health care leader with a... ...a dynamic, strategic thinking and collaborative Principal Scientist (director-level equivalent) to contribute to our company’s...PrincipalFull timeFor contractorsLocal areaWorldwideFlexible hours
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