Senior Scientist - Cardiometabolic Disorders

Senior Scientist - Cardiometabolic Disorders What you will do Let’s do this. Let’s change the world. In this vital role you will be an ideator and drug hunter and are expected to conduct biology research and identify therapeutic targets in cardiometabolic disease that are tractable and offer the opportunity of delivering disease-modifying potential in patients. The proposal and advancement of drug discovery programs will be based on a sound and compelling scientific rationale that may include validation from human genetics and/or clinical studies. Critical thinking, ingenuity, the ability to independently design mechanistic studies and conduct reproducible in vivo and in vitro pharmacology studies with high technical proficiency, excellent communication skills, integrity and the ability to work in a multi-disciplinary environment will be critical for this role. You will initially work at the bench and/or vivarium conducting in vivo and/or in vitro preclinical studies with a focus on osteoporosis and metabolic disease. Over time, you will also demonstrate strong leadership skills and the ability to manage a team of scientists conducting drug discovery research. As part of the team, you will also support other new and existing drug discovery programs in the department to help advance the best assets in the Cardiometabolic Disorders portfolio. Key Responsibilities Conceptualizing and proposing therapeutic targets for the treatment of bone disease and cardiometabolic disease Designing and performing in vitro and/or in vivo experiments Independently performing data analysis and interpreting results Communicating scientific results through written and oral presentations Collaborating with teams from other functions in the company to advance therapeutic candidates Documenting studies in electronic laboratory notebooks and study reports. Advising colleagues in areas of expertise What we expect of you We are all different, yet we all use our unique contributions to serve patients. The Senior Scientist we seek is a professional with these qualifications. Basic Qualifications Doctorate degree PhD PharmD MD [and relevant post‑doc where applicable] Master’s degree and 3 years of experience in bone metabolism and bone disease Bachelor’s degree and 5 years of experience in bone metabolism and bone disease Preferred Qualifications PhD with postdoctoral experience in bone metabolism and metabolic disease (industry experience is strongly preferred) Strong target ideation capabilities and critical thinking to enable discovery of innovative medicines for patients Exceptional in vivo and/or in vitro pharmacology skills and capability to independently design, implement and analyze studies with proper controls and generate reproducible high-quality data Technical mastery of general molecular biology and cell‑signaling analysis techniques including immunoblotting, immunocytochemistry, RT‑qPCR, immunoprecipitation, and ELISA Basic knowledge of statistical methods applied in a consistent and rigorous manner to all data sets generated Excellent written and oral communication skills and interpersonal skills that enable effective team interactions and communication of key data to all key stakeholders A strong ability to collaborate cross‑functionally in a multidisciplinary environment is critical Capability to deliver high quality manuscripts, posters and presentations for internal and external peer‑reviewed publication and conference attendance. Understanding of human genetics and genomic data mining for target identification are a plus. A high level of commitment to ensuring data reproducibility and data integrity What you can expect from us As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well‑being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way. A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts A discretionary annual bonus program, or for field sales representatives, a sales‑based incentive plan Stock‑based long‑term incentives Award‑winning time‑off plans Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies. Salary Range

127,121.75USD -171,988.25USD

Equal Opportunity Employer Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. #J-18808-Ljbffr Dormont Manufacturing Co