Senior Director, Global SOX

Revolution Medicines is a global, commercial-state oncology company dedicated to discovering, developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform, the company is advancing a broad, integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active, cancer-driving state of RAS. Founded on rigorous scientific inquiry and a willingness to challenge long-held assumptions, Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide.Our people are united by a shared way of working: follow the science, challenge assumptions, act with urgency and hold ourselves to a high standard of rigor—all in service of patients.The OpportunityRevMed is seeking an experienced, collaborative Senior Director, Global SOX to lead and scale the Company’s Sarbanes-Oxley compliance and internal controls program. This role has enterprise-wide governance responsibility for ICFR, ITGCs, ITACs, automated controls, key reports, and controls supporting evolving business processes, systems, commercial readiness, and global expansion.As a key Controllership leader, this role partners with functions, auditors, and process owners across the United States, Europe, Japan, Canada, and other markets. The leader will establish global SOX governance and practical regional execution, ensuring rigorous compliance while building risk-based, scalable controls that work effectively with business operations.This role reports to the VP, Finance, Controller, is based at RevMed’s Redwood City headquarters, and works closely with regional Finance, IT, and business teams.ResponsibilitiesGlobal SOX Program LeadershipLead RevMed’s global SOX and ICFR program, including annual planning, scoping, risk assessments, walkthroughs, documentation, testing coordination, deficiency evaluation, remediation tracking, and reporting.Develop a scalable operating model with centralized governance, consistent standards, clear accountability, and right-sized controls that maintain compliance without unnecessary operational burden.Partner with Accounting, SEC Reporting, Technical Accounting, IT, Commercial, Supply Chain, Legal, HR, and regional teams to identify financial reporting risks and ensure controls are well designed, documented, owned, and effective.Maintain SOX documentation, including risk and control matrices, narratives, flowcharts, key reports, management review controls, and regional certifications or attestations.Provide quarterly and annual SOX updates to the Controller, senior management, and the Audit Committee, including status, key risks, deficiencies, and remediation progress.ITGC, Systems and Commercial ReadinessLead the global ITGC program for enterprise and regional systems supporting financial reporting, including ERP, procurement, payroll, equity, SEC reporting, lease accounting, commercial, inventory, consolidation, and other in-scope applications.Oversee ITGC domains such as user access, privileged access, change management, SDLC, computer operations, interfaces, data integrity, cybersecurity dependencies, and third-party providers.Partner with IT, Information Security, system owners, and process owners to assess control implications of new systems, integrations, cross-border data flows, and significant configuration changes.Embed controls by design in system implementations, regional deployments, localizations, and significant process changes, including access provisioning, change management, report validation, and post-implementation readiness.Support controls over commercialization and operational processes, including order-to-cash, gross-to-net, revenue recognition, inventory, third-party logistics, distributors / specialty pharmacies, patient support, government pricing / rebates, and country launches.Auditor Coordination, Remediation and Team LeadershipServe as the global SOX liaison with internal and external auditors, process owners, IT, Information Security, and other stakeholders to support efficient walkthroughs, testing, evidence submission, and issue resolution.Coordinate the global SOX calendar, PBC requests, control-owner responses, audit deliverables, and consolidated status reporting across regions and time zones.Identify audit bottlenecks, documentation gaps, control design issues, testing matters, and opportunities to simplify or automate controls while maintaining compliance and auditability.Lead evaluation and remediation of control observations and deficiencies, including root cause, severity, impact, remediation plans, and validation of operating effectiveness.Build and develop a high-performing global SOX and ITGC function, including employees, regional resources, consultants, and co-sourced providers.Required Skills, Experience and Education:Bachelor’s degree or higher in Accounting, Finance, Information Systems, Business Administration, or a related field.CPA, CIA, CISA, or equivalent certification strongly preferred; at least one relevant certification expected.12+ years of progressive experience in SOX, internal controls, IT audit, public accounting, internal audit, controllership, or related fields.Significant experience leading a SOX 404 program for a publicly traded, multi-entity company with international operations.Deep knowledge of SOX 404, COSO, PCAOB auditing standards, SEC reporting requirements, ICFR, management review controls, and financial reporting risk assessment.Strong ITGC and ITAC experience across access, change management, SDLC, computer operations, interfaces, automated controls, key reports, SOC report review, CUECs, and third-party provider controls.Experience supporting global ERP or financial system implementations, upgrades, integrations, or transformations.Strong understanding of close, consolidation, intercompany, foreign currency, SEC reporting, equity, payroll, procurement, AP, treasury, leases, revenue, inventory, and other significant accounting processes.Proven ability to influence cross-functional and cross-cultural stakeholders, drive accountability, and communicate clearly with senior leaders, auditors, control owners, and technical and non-technical audiences.Preferred Skills:Experience in a global biotech, pharmaceutical, life sciences, or healthcare company preparing for or operating in a commercial-stage environment.Experience with multi-country launch readiness, revenue recognition, gross-to-net, inventory, third-party logistics, government pricing, specialty distributors / pharmacies, or patient support programs.Experience with NetSuite, Coupa, Workday, ADP, equity platforms, Active Disclosure / Workiva, lease and commercial systems, GRC / SOX tools, data warehouses, and reporting platforms.Experience building or scaling an in-house global SOX function, including centralized standards and regional execution.Experience implementing SOX automation, evidence workflows, dashboards, analytics, or AI-enabled monitoring.Public accounting or Big 4 / national firm experience strongly preferred.#LI-GL1 #LI-HybridThe base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact View email address on click.appcast.io Pay Salary Range$244,000—$305,000 USDWe are aware of recent recruitment scams in which individuals or organizations falsely represent themselves as being affiliated with Revolution Medicines. These scams may appear as false job advertisements or unsolicited contacts through communication or chat platforms, email, phone, or text message.Please note that Revolution Medicines does not extend unsolicited employment offers and will never ask candidates to provide financial information, purchase equipment, or pay fees as part of the hiring process. All legitimate communication from Revolution Medicines will come from an official @revmed.com email address.If you believe you’ve been contacted by someone impersonating a Revolution Medicines recruiter, please report it to View email address on click.appcast.io so we can share these impersonations with our IT team for tracking and awareness.