Senior Scientist / Principal / Director Translational Research

We are seeking a highly motivated and scientifically rigorous individual as a Senior Scientist, Principal Scientist, or Director of Translational Research to lead translational strategy and execution for our pipeline. This individual will be primarily responsible for identifying and validating development opportunities in multiple disease areas, and planning and performing proof-of-concept studies across preclinical in vitro and in vivo models. A second area of focus will be the development and implementation of potential predictive and pharmacodynamic biomarkers for Neomorph’s clinical studies.The role is highly cross-functional and will work closely with Research Biology, Clinical Development/Clinical Operations, Data Sciences (Bioinformatics), and external collaborators/CROs. The ideal candidate has deep biology expertise in human disease biology, strong translational research experience, and the ability to operate effectively in a fast-paced, small-company environment. Key ResponsibilitiesIdentify and validate development opportunities across the Neomorph pipeline in oncology and non-oncology. Design and oversee preclinical translational studies using in vitro and in vivo models (e.g., cell lines, organoids, xenografts, PDX models, ex vivo patient samples) and relevant molecular profiling platforms. Support indication expansion, combination strategies, dose selection, and dose schedule optimization through translational research. Stay current with the target’s biology, competitors, and emerging therapeutic mechanisms. Oversee external vendors, academic collaborators, and CROs. Collaborate with Bioinformatics/Biometrics to analyze and interpret translational datasets, including genomics, transcriptomics, proteomics, pharmacodynamic, and clinical outcome data. Contribute to regulatory documents, including INDs, clinical protocols, investigator brochures, annual reports, and responses to health authority questions. Present translational data and strategy to internal leadership and external partners. Biomarker discovery, development, and clinical implementation: Develop and implement predictive biomarkers to support patient selection for Neomorph’s clinical studies. Develop and implement pharmacodynamic biomarkers for Neomorph’s clinical studies. Clinical biomarker strategies include tissue and blood-based assays, e.g., LC-MS, IHC/IF, NGS, ELISA, and other potential biomarker readouts. Oversee external vendors and CROs for clinical biomarker test development, validation, and analyses. Partner with Clinical Development/Operations to integrate biomarkers into Phase 1/2 clinical protocols and to implement biospecimen collection, processing, shipment, testing, and data analysis. QualificationsPhD, MD, MD/PhD, PharmD, or equivalent advanced degree in biology or genomics, molecular biology, translational medicine, or a related discipline. Sr. Scientist: 5+ years of relevant experience; Principal Scientist: 8+years of relevant experience; or Director: 12+ years of relevant experience in drug discovery, translational research, and clinical biomarker development, with biotech/pharma experience preferred. Experience supporting programs in IND-enabling, Phase 1, and/or Phase 2 clinical development. Experience with in vitro and in vivo models (e.g., cell lines, organoids, xenografts, PDX models, ex vivo patient samples) and relevant molecular profiling. Hands-on experience with biomarker assays such as e.g., LC-MS, IHC, IF, ctDNA, NGS, RNA-seq, flow cytometry, proteomics, single-cell methods, etc. Demonstrated ability to translate preclinical biology into clinical biomarker and patient-selection strategies. Experience managing CROs, academic collaborations, and external translational vendors. Strong data interpretation skills and ability to integrate complex biological, pharmacodynamic, and clinical datasets. Excellent written and verbal communication skills. Ability to work independently, prioritize effectively, and thrive in a, fast-moving biotech environment. Preferred ExperienceExperience in oncology and at least one non-oncology disease area is a plus. Experience with PD biomarker development and predictive biomarker strategies for patient enrichment. Experience with targeted protein degradation is a plus. Prior experience contributing to IND submissions or early clinical oncology protocols. Familiarity with companion diagnostic or exploratory diagnostic development. Key CompetenciesScientific leadership and strategic thinking. Translational and clinical-development mindset. Strong human biology expertise. Cross-functional collaboration. Vendor and project management. Clear communication with scientific and non-scientific stakeholders. Hands-on problem solving in a small-company environment. Ability to balance scientific rigor with practical execution. What we offer:Industry-competitive compensationAnnual target bonusStock options401K planCareer advancement opportunitiesMonthly town halls to share business and scientific updatesWork Hard, Stay WellComprehensive medical, dental, and vision plans for employees and their dependentsHealth and Dependent Care FSA and HSA Plan with monthly Neomorph contributionEmployee Assistance Program10 holidays + Winter Shutdown + 3 weeks of vacation time with additional accruals after 2nd year of employment, separate sick leave.Supplemental pay for Pregnancy Disability LeavePaid Parental Leave for employees with a newborn child or a child placed with them for adoption or foster careLifestyleCasual work environmentVolunteer days off each year to spend time contributing to causes you care aboutFlexible work scheduleAccess to onsite gymOnsite space to store your bicycle (or surfboard) Have Fun!We believe in work/life balance and Fun is at the core of our Core Values. In addition to department and company happy hours, we have regular company-wide and department lunches and social events (ie Padres games, summer picnic, holiday party, bring your kids to work day).About Us:Neomorph is a venture backed biotechnology company solving critical problems in human health through the discovery and development of innovative new medicines against ‘undruggable targets’. Our team is comprised of industry leading experts in protein degradation and molecular glues who have a track record of ground-breaking discoveries in the field. We are committed to leadership in advancing the science and technology of molecular glue drug discovery, while prosecuting a pipeline of projects through clinical development. Our patient-first, science-driven approach is complemented by our dedication to a supportive and collaborative work environment. Neomorph is headquartered in San Diego, California.Neomorph is committed to pursuing and hiring a diverse workforce and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of any characteristic protected by applicable federal, state or local law.Notice to agencies: Neomorph will not accept unsolicited assistance from recruiting/search agencies for this employment opportunity. Please, no phone calls or emails. All resumes submitted by recruiting or search agencies to any employee at Neomorph via email, the Internet or in any form and/or method without a valid written search/recruitment agreement in place for this position will be deemed the sole property of Neomorph. No fee will be paid in the event the candidate is hired by Neomorph as a result of the referral or through other means.