Director/Senior Director, Analytical Methods (Methods4Insight)

Reports to: AVP - Methods4Insight, Data Foundry. Overview At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees across the world work to discover and bring life‑changing medicines to those who need them, improve disease understanding and management, and give back to communities through philanthropy and volunteerism. Lilly Small Molecule Discovery is purpose‑built to create molecules that improve lives. We use cutting‑edge science to unlock new treatment approaches for diseases with limited options, delivering breakthrough efficacy with the highest safety margins. Our culture empowers innovative problem solving through open collaboration and individual accountability. Discovery Technology and Platforms This newly established function accelerates molecule discovery by building optimized foundational platforms, streamlining lab operations through advanced technologies and data connectivity, and investing in novel capabilities. About Data Foundry Data Foundry is a multidisciplinary team dedicated to enabling and accelerating molecule discovery through scalable and reproducible data generation, advanced scientific computing, informatics, and automation solutions. It operates through four pillars: Architecture4Insight, Methods4Insight, Scale4Insight, and Preparedness4Insight, which together empower scientists to make optimal decisions with seamless data access and AI‑driven capabilities. Position Summary The Director/Senior Director, Analytical Methods will serve as a domain expert and technical leader within Methods4Insight, responsible for developing, deploying, and maintaining cutting‑edge analytical approaches in areas such as cheminformatics, computational structural biology, statistical modeling, or AI/ML. This role combines deep domain knowledge with scientific leadership, translating advanced methods into practical capabilities that accelerate molecule discovery for human scientists and autonomous AI agents. What You’ll Do Serve as the subject‑matter expert in your analytical domain, staying current on innovative methods and making informed recommendations about adoption, adaptation, or development of novel approaches. Develop and deploy cutting‑edge analytical methods tailored to Lilly’s discovery challenges, building workflows that integrate multiple approaches to harness complementary strengths. Translate complex scientific questions into tractable analytical problems, driving analyses that inform compound prioritization, design recommendations, and mechanism of action hypotheses. Collaborate with Architecture4Insight to deploy analytical methods as accessible tools and agent‑ready capabilities with well‑defined APIs for autonomous AI decision‑making. Identify strategic data gaps in your domain and partner with Scale4Insight to design targeted experiments that generate high‑value data. Establish best practices for method validation, including prospective testing against experimental outcomes, and demonstrate impact through tracked metrics such as decisions influenced, hypotheses generated, and timelines accelerated. Collaborate across all Data Foundry pillars and with Frontier AI to ensure analytical capabilities are fully integrated into the broader discovery ecosystem. Publish peer‑reviewed research, present at scientific conferences, and build analytical literacy across the organization. Mentor junior computational scientists and contribute to a culture of scientific rigor, reproducibility, and continuous improvement. Basic Requirements MS/Ph.D. in Cheminformatics, Computational Biology, Biophysics, Applied Mathematics, Computer Science, Statistics, or a related quantitative field. 6+ years of experience developing and applying analytical methods in drug discovery or related life sciences fields. Additional Preferences Deep expertise in at least one analytical domain with demonstrated impact on scientific outcomes. Strong programming skills in Python, R, or similar scientific computing languages. Publications in peer‑reviewed journals demonstrating contributions to your analytical domain. Ability to explain complex analytical concepts clearly to non‑computational scientists. Track record of deploying analytical methods that influenced real scientific decisions or discoveries. Breadth across multiple analytical approaches, with experience both developing novel methods and adopting external approaches. Familiarity with software engineering practices and deploying research code in production environments. Experience mentoring junior scientists or managing interns/postdocs. Ability to communicate effectively across scientific, technical, and executive audiences. Passion for mentoring and empowering others. Additional Information Physical Demands/Travel: This position requires typical office work and travel. Work Environment: This role is primarily in an office setting. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions of this job. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form for further assistance. EEO Statement Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Compensation & Benefits Actual compensation will depend on education, experience, skills, and geographic location. The anticipated wage for this position is $193,500–$338,800. Full‑time equivalent employees will also be eligible for a company bonus, as well as a comprehensive benefit program that includes 401(k) participation, pension, vacation, medical, dental, vision, prescription drug, flexible spending accounts, life insurance, death benefits, time off, and well‑being benefits such as an employee assistance program, fitness benefits, and employee clubs and activities. Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion, and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees. #J-18808-Ljbffr 100 Eli Lilly and Company