Senior Associate Scientist

Working with Us Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us. Position Summary We are seeking a highly motivated Senior Associate Scientist to join our Discovery Biotherapeutics organization in Cambridge, MA. This role will help advance high throughput, automated mammalian antibody expression capability within Discovery Biotherapeutics. The Senior Associate Scientist will operate automation‑enabled platforms that accelerate antibody discovery and engineering, including complex and multispecific biologics. Working at the interface of mammalian expression biology, laboratory automation, and software enabled workflows, this position enables scalable, integrated discovery approaches that increase speed and impact across early biologics programs. This lab-facing role offers an exciting opportunity to make a meaningful scientific contribution in support of BMS’s mission of delivering innovative medicines to patients. Experience in protein production and purification is required for this role as well as the ability to operate, troubleshoot, and help develop novel automation systems and solutions. A background in AKTA/Unicorn programming and liquid handler operation will be helpful, but the candidate must have a strong interest in automation and a proven track record of innovation and problem solving. Key Responsibilities Strong background in molecular biology ie primer design, cloning, sequence analysis, and HT-PCR is required. Discovery-stage mammalian expression of antibodies and antibody-derived formats, including IgGs, fragments, and multispecific biologics in HT-plate based workflows. Experience with high-throughput, automated expression and purification workflows: 4mL through 100mL scale and QC analytics for protein production including A280 protein concentration measurements, CE-SDS, SDS-PAGE, HT-anSEC, and endotoxin testing. Background using liquid handling systems such as Lynx 1800, Biomek i7 or equivalent and familiarity with plate-based purification schemes. Experience working with automation teams to integrate liquid handling, incubators, culture handling, and downstream processing steps is a bonus. Interface with laboratory software platforms to ensure high-quality, traceable data generation compatible with computational and ML-driven discovery. Software includes Benchling, Geneious Prime, Electronic notebook documentation. Collaborate with AI/ML, binder discovery, molecular interaction, and functional assay teams to support binder discovery campaigns. The willingness to learn new workflows and work in mid-scale production / purification is desirable. Qualifications & Experience BS with 4+ years; or MS with 2+ years of pharmaceutical R&D or related industry experience. Molecular biology background with a strong understanding of cloning and high throughput fragment DNA generation. Experience with HTP-scale and mid-scale protein production and operating high-throughput, automated expression workflows. Hands on experience in the operation and control of AKTA chromatography workstations and liquid handling systems like Lynx 1800 and Biomek i7. Experience in mammalian antibody expression, purification and ability to troubleshoot standard purification protocols and instrumentation. Strong understanding of HEK293, CHO, CFE or equivalent expression systems. Strong interpersonal skills and ability to work independently while influencing cross-functional discovery of biotherapeutics, biology, automation, and engineering teams. Excellent written and verbal communication skills and ability to work with a sense of urgency under tight deadlines. Experience with LIMS systems and Electronic Notebook is a plus. Compensation Overview Cambridge Crossing: $106,510 - $129,059 The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee’s work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience. Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit Benefit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment. Our benefits include: Health Coverage: Medical, pharmacy, dental, and vision care. Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP). Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support. Work-life benefits include: Paid Time Off US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees) Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays Based on eligibility*, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day. All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown. *Eligibility Disclosure: The summer hours program is for United States (U.S.) office-based employees due to the unique nature of their work. Summer hours are generally not available for field sales and manufacturing operations and may also be limited for the capability centers. Employees in remote-by-design or lab-based roles may be eligible for summer hours, depending on the nature of their work, and should discuss eligibility with their manager. Employees covered under a collective bargaining agreement should consult that document to determine if they are eligible. Contractors, leased workers and other service providers are not eligible to participate in the program. Uniquely Interesting Work, Life-changing Careers With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues. On-site Protocol BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role: Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function. Supporting People with Disabilities BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to View email address on click.appcast.io. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement. Candidate Rights BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area. If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: We’re creating innovative medicines for patients fighting serious diseases. We’re also nurturing our own diverse team with inspiring work and challenging career options. No matter the role, each one of us makes a contribution. And that makes all the difference. #J-18808-Ljbffr Bristol-Myers Squibb