Optimization Research Scientist
The Vanguard Group
Core ResponsibilitiesPartner directly with senior business and investment stakeholders to uncover high-value opportunities, develop + iteratively refine hypotheses, and translate ambiguous questions into structured research problems.Formulate complex business and investment challenges as optimization problems, defining objectives, constraints, tradeoffs, decision variables, and measurable success criteria.Build and evaluate quantitative, statistical, machine learning, simulation, and optimization frameworks that support practical decision-making in real-world investment settings.Work with incomplete, noisy, fragmented, or evolving data to create usable research datasets, document assumptions, and assess the implications of data limitations.Design rigorous evaluation approaches, including out-of-sample testing, simulation, backtesting, sensitivity analysis, robustness testing, and constraint validation.Iterate closely with stakeholders, researchers, data scientists, and engineering partners to refine hypotheses, improve frameworks, and move promising research toward scalable implementation.Communicate findings, tradeoffs, assumptions, and recommendations clearly to business leaders, with a focus on decision impact and actionable next steps.Qualifications:Experience in applied research, quantitative modeling, optimization, and machine learning, with the ability to independently drive ambiguous research efforts from problem discovery through recommendation.Strong ability to partner directly with senior business stakeholders to uncover high-value opportunities, develop hypotheses, and translate loosely defined questions into rigorous analytical or optimization approaches.Experience formulating complex business or investment problems in terms of objectives, constraints, tradeoffs, decision variables, and measurable outcomes.Strong experience building optimization models to support decision-making in real-world settings, experience with statistical, machine learning, and deep learning is a plus.Comfort working with incomplete, noisy, fragmented, or evolving data, including the ability to make pragmatic assumptions, document limitations, and keep research moving despite imperfect inputs.Experience designing and interpreting evaluation frameworks using out-of-sample testing, simulation, backtesting, sensitivity analysis, or robustness analysis.Proficiency in Python and comfort working in development environments such as SageMaker, Databricks, or similar platforms; familiarity with optimization libraries, solvers, or computational decision frameworks is valuable.Experience with quantitative finance, systematic workflows, or investment management problems is preferred; participation in the CFA program or related financial education is valuable.Special FactorsSponsorshipVanguard is not offering visa sponsorship for this position.About VanguardAt Vanguard, we don't just have a mission—we're on a mission.To work for the long-term financial wellbeing of our clients. To lead through product and services that transform our clients' lives. To learn and develop our skills as individuals and as a team. From Malvern to Melbourne, our mission drives us forward and inspires us to be our best.How We WorkVanguard has implemented a hybrid working model for the majority of our crew members, designed to capture the benefits of enhanced flexibility while enabling in-person learning, collaboration, and connection. We believe our mission-driven and highly collaborative culture is a critical enabler to support long-term client outcomes and enrich the employee experience.SummaryLocation: Malvern, PAType: Full time
- ABOUTFrontage Laboratories is a CRO / Clinical Research Organization providing integrated, science-driven, product development services... ...pharmaceutical sciences, clinical pharmacology and regulatory to optimize leads, select clinical candidates, conduct preclinical...Suggested
- Scientist/Senior Scientist - Cell Bioassay/Potency Title: Scientist/Sr. Scientist, Cell Bioassay... ...winning, full-service, CRO/Contract Research Organization operating over 25 state-of-... ...With dedication to troubleshooting and optimizing assays on bench, this position may lead...SuggestedContract work
- ...searching for the best talent for a Principal Scientist, Product Characterization - Advanced... ...with the design, execution and optimization of a broad range of characterization assays... ...Manufacturing, and Control (CMC), Clinical Research and Regulations, Clinical Trial Designs...SuggestedFull timeLocal area
- Sr. Scientist/Scientist, Pharmaceutical Drug DevelopmentTitle: Sr. Scientist/Scientist Location... ...winning, full-service, CRO/Contract Research Organization operating over 25 state-of... ...development, process development, optimization, and technology transfer.Incorporate Quality...SuggestedContract work
- Job Title: Senior Scientist / Principal Scientist - Biotransformation/Metabolite Identification.Location: Exton, PennsylvaniaFull-time... ...characterize drug metabolites in vitro and in vivo.Develop and optimize sample preparation and analytical techniques for metabolite...Suggested
$55k - $65k
...Description Job Description Position: Scientist II, Discovery DMPK Salary Range: $55,... ...Pharmaron is a global contract research and manufacturing organization (CRO/CDMO... ...in vitro ADME programs. Execute and optimize LC-MS/MS assays following established development...Full timeContract workTemporary workWork at officeWorldwideFlexible hours- ...Description Job Description Senior/Principal Scientist – Process Chemistry Senior/Principal... ...(HKSE), full-service CRO/Contract Research Organization operating over 25 state-of... ...to lead route scouting, process optimization, scale-up, and GMP batch support for small...Contract workFlexible hours
$55k - $65k
Position: Scientist I/II - HPLC Method Development Salary Range: $55,000-$65,000 Location... ...Pharmaron is a global contract research and manufacturing organization (CRO/CDMO... ...Method Development , you will develop, optimize, troubleshoot, and validate chromatographic...Contract workTemporary workWorldwideFlexible hours- ...Description Job Description Associate Scientist (Pharmacokinetics) – Biologics Job... ...award winning, full-service, CRO/Contract Research Organization operating over 25 state-of-... ...Key Responsibilities: Develop, optimize, and validate ligand binding assays (e.g...Full timeContract workInternship
- Sr. Scientist - CMC Analytical ServicesTitle: Sr. ScientistLocation: Exton, PAFull-timeFrontage Laboratories Inc. is an award winning, full-service, CRO/Contract Research Organization operating over 25 state-of-the-art laboratories across the US, Canada and China. Our...Contract work
- Scientist/Sr. Scientist Division/Department: Analytical Services, CMC (Chemistry, Manufacturing, and Controls) Reports to: Manager/Group... ...Inc. is an award winning, full-service, CRO/Contract Research Organization operating over 25 state-of-the-art laboratories across...Contract work
- Scientist, BiologicsLocation: Exton, PAFull-timeFrontage Laboratories Inc. is an award winning, full-service, CRO/Contract Research Organization operating over 25 state-of-the-art laboratories across the US, Canada and China. Our core competencies include drug metabolism...Contract work
- Scientist/Sr. Scientist—Automation Location: Exton, PAFull-timeFrontage Laboratories Inc. is an award winning, full-service, CRO/Contract Research Organization operating over 25 state-of-the-art laboratories across the US, Canada and China. Our core competencies include...Contract work
- Senior Scientist-BiologicsTitle: Senior Scientist, Biologics Location: Exton,PA Full-timeFrontage Laboratories Inc. Frontage Laboratories Inc. (Frontage) is a global contract research organization with broad expertise in supporting pre-clinical and clinical drug development...Contract work
- Senior Scientist - BiologicsLocation: Exton PAFull-timeFrontage Laboratories Inc. is an award winning, full-service, CRO/Contract Research Organization operating over 25 state-of-the-art laboratories across the US, Canada and China. Our core competencies include drug metabolism...Contract workWork at office
- Scientist/ Senior Scientist/ Principal Scientist, method Developer, Large Molecules Quantitation by LC-MS/MS, Bioanalytical ServicesLocation: Exton, PA (Corporate)Full timeResponsibilities:Mainly responsible for developing bioanalytical quantitation methods for large molecules...Temporary workWork experience placement
- ...their merit.We are searching for the best talent for a Principal Scientist, In-vivo CAR-T Potency Method Development to be located in... ...Biotechnology, Chemistry, Manufacturing, and Control (CMC), Clinical Research and Regulations, Clinical Trial Designs, Coaching, Critical...Full timeLocal area
- Senior Method development scientist-Biomarker LC-MS/MSTitle: Senior method development scientist- Biomarker LC-MS/MSLocation: 700 Pennsylvania... ...Inc. is an award winning, full-service, CRO/Contract Research Organization operating over 25 state-of-the-art laboratories across...Contract work
- In vitro ADME Senior/Principal Scientist - DMPKLocation: Exton, PA Department: DMPK (Drug Metabolism & Pharmacokinetics)Employment Type... ...an award winning, publicly listed, full-service CRO/Contract Research Organization operating over 25 state-of-the-art laboratories across...Contract workTemporary work
- ...throughput liquid handlers, sequencers, or PCR platforms. Provide technical assistance for new sequencing platform search, review, optimization, and validation. Perform whole genome sequencing (WGS) on pathogenic bacteria, viruses, and fungi, including wet‑lab genomic...Work experience placementWork at officeMonday to FridayShift work
- ...individual career goals while taking science a step beyond through research, development and delivery of life-changing therapies. With... ...impact on improving patient health through the expertise of scientists, industry thought-leaders and therapeutic experts. As the world...Full timeWork at officeImmediate startRelocationFlexible hours
- Associate Scientist, Bioanalytical ServicesTitle: Associate Scientist, Bioanalytical ServicesLocation: Exton, PA (Corporate)Responsibilities:Associate Scientist / Bioanalytical Services Essential Functions Provide support for running sensitive, reliable and efficient LC...Temporary work
- Associate Scientist, Pharmaceutical Analysis-Small MoleculeLocation: Exton, PAFull-timeFrontage Laboratories Inc. is an award winning, full-service, CRO/Contract Research Organization operating over 25 state-of-the-art laboratories across the US, Canada and China. Our...Contract work
- ...understanding and make use of wider Arkema analytical and material testing capabilitiesPerform data analysisMaintain a well-organized research notebookContribute to internal discussions as needed and generate reports for internal distributionWork as part of a cross-...Contract work
- Associate Scientist-BiologicsLocation: Exton, PAFull-timeFrontage Laboratories Inc. is an award winning, full-service, CRO/Contract Research Organization operating over 25 state-of-the-art laboratories across the US, Canada and China. Our core competencies include drug...Contract work
- Associate Scientist/Scientist- Cell-Based Assay Core FacilityTitle: Associate Scientist/Scientist Location: Exton PAReports to: Associate... ...Inc. is an award winning, full-service, CRO/Contract Research Organization operating over 25 state-of-the-art laboratories across...Contract work
- Associate Scientist/Scientist - Biologics - BDDS Full Time Exton, PA Frontage Laboratories Frontage Laboratories Inc. is an award winning, full-service, CRO/Contract Research Organization operating over 25 state-of-the-art laboratories across the US, Canada and China....Full timeContract work
- Scientist/Associate Scientist- BiomarkerTitle: Scientist/Associate Scientist, BiomarkerLocation: Exton, PAFull-timeFrontage Laboratories Inc. is an award winning, full-service, CRO/Contract Research Organization operating over 25 state-of-the-art laboratories across the...Contract work
- ...We are looking for a Research Scientist Intern to push the state of the art of our AI models. As a Research Scientist Intern at Whiterabbit.ai, you will: Play a key role in architecting the algorithms and models that will power our products Train on a dedicated...Remote jobInternship
$100k - $135k
Must Have Technical/Functional Skills • AWS Data Scientist with strong expertise in Amazon SageMaker, Python, Machine Learning, MLOps,... ...Analytics services, capable of building, deploying, monitoring, and optimizing scalable ML/AI solutions, including GenAI workloads on AWS. •...
Do you want to receive more vacancies?
Subscribe and receive similar vacancies to Optimization Research Scientist. Be the first to apply!
- water quality scientist Malvern, PA
- rn research Malvern, PA
- remote legal research Malvern, PA
- research registered nurse Malvern, PA
- research program officer Malvern, PA
- research and development analyst Malvern, PA
- education policy research Malvern, PA
- research nurse Malvern, PA
- research and development internship Malvern, PA
- undergraduate summer research internship Malvern, PA


