Sign up to access all features of our service.
  • Job search
  • Favorites
  • Create a CV
    New
  • Salaries
  • Subscriptions

Optimization Research Scientist

Vanguard

Core ResponsibilitiesPartner directly with senior business and investment stakeholders to uncover high-value opportunities, develop + iteratively refine hypotheses, and translate ambiguous questions into structured research problems.Formulate complex business and investment challenges as optimization problems, defining objectives, constraints, tradeoffs, decision variables, and measurable success criteria.Build and evaluate quantitative, statistical, machine learning, simulation, and optimization frameworks that support practical decision-making in real-world investment settings.Work with incomplete, noisy, fragmented, or evolving data to create usable research datasets, document assumptions, and assess the implications of data limitations.Design rigorous evaluation approaches, including out-of-sample testing, simulation, backtesting, sensitivity analysis, robustness testing, and constraint validation.Iterate closely with stakeholders, researchers, data scientists, and engineering partners to refine hypotheses, improve frameworks, and move promising research toward scalable implementation.Communicate findings, tradeoffs, assumptions, and recommendations clearly to business leaders, with a focus on decision impact and actionable next steps.Qualifications:Experience in applied research, quantitative modeling, optimization, and machine learning, with the ability to independently drive ambiguous research efforts from problem discovery through recommendation.Strong ability to partner directly with senior business stakeholders to uncover high-value opportunities, develop hypotheses, and translate loosely defined questions into rigorous analytical or optimization approaches.Experience formulating complex business or investment problems in terms of objectives, constraints, tradeoffs, decision variables, and measurable outcomes.Strong experience building optimization models to support decision-making in real-world settings, experience with statistical, machine learning, and deep learning is a plus.Comfort working with incomplete, noisy, fragmented, or evolving data, including the ability to make pragmatic assumptions, document limitations, and keep research moving despite imperfect inputs.Experience designing and interpreting evaluation frameworks using out-of-sample testing, simulation, backtesting, sensitivity analysis, or robustness analysis.Proficiency in Python and comfort working in development environments such as SageMaker, Databricks, or similar platforms; familiarity with optimization libraries, solvers, or computational decision frameworks is valuable.Experience with quantitative finance, systematic workflows, or investment management problems is preferred; participation in the CFA program or related financial education is valuable.Special FactorsSponsorshipVanguard is not offering visa sponsorship for this position.About VanguardAt Vanguard, we don't just have a mission—we're on a mission.To work for the long-term financial wellbeing of our clients. To lead through product and services that transform our clients' lives. To learn and develop our skills as individuals and as a team. From Malvern to Melbourne, our mission drives us forward and inspires us to be our best.How We WorkVanguard has implemented a hybrid working model for the majority of our crew members, designed to capture the benefits of enhanced flexibility while enabling in-person learning, collaboration, and connection. We believe our mission-driven and highly collaborative culture is a critical enabler to support long-term client outcomes and enrich the employee experience.SummaryLocation: Malvern, PAType: Full time

Vacancy posted 2 days ago
Similar jobs that could be interesting for youBased on the Optimization Research Scientist in Malvern, PA vacancy
  •  ...making. Mentors and develops junior data scientists and analysts.3. Identifies and...  ...analytic approach.5. Guides test design, research design, and model validation. Provides...  ...coursework in mathematics, statistics, optimization, machine learning, or related analytical... 
    Suggested
    Full time

    Vanguard

    Malvern, PA
    6 days ago
  • ABOUTFrontage Laboratories is a CRO / Clinical Research Organization providing integrated, science-driven, product development services...  ...pharmaceutical sciences, clinical pharmacology and regulatory to optimize leads, select clinical candidates, conduct preclinical... 
    Suggested

    Frontage Laboratories

    Exton, PA
    5 days ago
  • Scientist/Senior Scientist - Cell Bioassay/Potency Title: Scientist/Sr. Scientist, Cell Bioassay...  ...winning, full-service, CRO/Contract Research Organization operating over 25 state-of-...  ...With dedication to troubleshooting and optimizing assays on bench, this position may lead... 
    Suggested
    Contract work

    Frontage Laboratories

    Exton, PA
    5 days ago
  •  ...inclusion across race, gender, age, religion, identity, and experience to drive us forward every day. Overview (Scope of Role) The Research Scientist will lead a portfolio of R&D initiatives to strengthen the PMMA Resins and Surfaces product portfolios and deliver new... 
    Suggested

    Unavailable

    Exton, PA
    3 days ago
  •  ...searching for the best talent for a Principal Scientist, In-vivo CAR-T, to be based on-site in...  ...will support the development, optimization, and scale-up of lentiviral vector (LVV...  ...Manufacturing, and Control (CMC), Clinical Research and Regulations, Clinical Trial Designs... 
    Suggested
    Full time
    Local area

    Johnson & Johnson

    Malvern, PA
    4 days ago
  •  ...searching for the best talent for a Principal Scientist, Product Characterization - Advanced...  ...with the design, execution and optimization of a broad range of characterization assays...  ...Manufacturing, and Control (CMC), Clinical Research and Regulations, Clinical Trial Designs... 
    Full time
    Local area

    Johnson & Johnson

    Malvern, PA
    4 days ago
  • Sr. Scientist/Scientist, Pharmaceutical Drug DevelopmentTitle: Sr. Scientist/Scientist Location...  ...winning, full-service, CRO/Contract Research Organization operating over 25 state-of...  ...development, process development, optimization, and technology transfer.Incorporate Quality... 
    Contract work

    Frontage Laboratories

    Exton, PA
    5 days ago
  • Job Title: Senior Scientist / Principal Scientist - Biotransformation/Metabolite Identification.Location: Exton, PennsylvaniaFull-time...  ...characterize drug metabolites in vitro and in vivo.Develop and optimize sample preparation and analytical techniques for metabolite... 

    Frontage Laboratories

    Exton, PA
    5 days ago
  • $55k - $65k

     ...Description Job Description Position: Scientist II, Discovery DMPKSalary Range: $55,000-...  ...PharmaronPharmaron is a global contract research and manufacturing organization (CRO/CDMO...  ...and in vitro ADME programs. Execute and optimize LC-MS/MS assays following established... 
    Contract work
    Temporary work
    Work at office
    Worldwide
    Flexible hours

    Pharmaron

    Exton, PA
    3 days ago
  •  ...searching for the best talent for Senior Scientist, Modeler, to join our team in Malvern...  ...series modeling, process characterization, optimization, scale translation, data interpretation...  ...Assurance (QA), Relationship Building, Research Documents, Scientific Research,... 
    Full time
    Local area

    Johnson & Johnson

    Malvern, PA
    4 days ago
  •  ...Description Job Description Senior/Principal Scientist – Process Chemistry Senior/Principal...  ...(HKSE), full-service CRO/Contract Research Organization operating over 25 state-of...  ...to lead route scouting, process optimization, scale-up, and GMP batch support for small... 
    Contract work
    Flexible hours

    Frontage Laboratories

    Exton, PA
    6 days ago
  • $98k - $106k

     ...responsible for method feasibility, method development, method optimization, method transfers, method qualifications, method validations...  ...interaction, interpretation and reporting of data of assigned research projectsJob DescriptionESSENTIAL DUTIES AND RESPONSIBILITIES:Perform... 
    Contract work
    For subcontractor
    Local area
    Worldwide
    Flexible hours

    Charles River

    Wayne, PA
    5 days ago
  • Sr. Scientist - CMC Analytical ServicesTitle: Sr. ScientistLocation: Exton, PAFull-timeFrontage Laboratories Inc. is an award winning, full-service, CRO/Contract Research Organization operating over 25 state-of-the-art laboratories across the US, Canada and China. Our... 
    Contract work

    Frontage Laboratories

    Exton, PA
    3 days ago
  • Title: Senior Scientist, BiomarkerLocation: Full-timeFrontage Laboratories Inc. is an award winning, full-service, CRO/Contract Research Organization operating over 25 state-of-the-art laboratories across the US, Canada and China. Our core competencies include drug metabolism... 
    Contract work

    Frontage Laboratories

    Exton, PA
    5 days ago
  • Scientist, BiologicsLocation: Exton, PAFull-timeFrontage Laboratories Inc. is an award winning, full-service, CRO/Contract Research Organization operating over 25 state-of-the-art laboratories across the US, Canada and China. Our core competencies include drug metabolism... 
    Contract work

    Frontage Laboratories

    Exton, PA
    4 days ago
  • Scientist/Sr. Scientist Division/Department: Analytical Services, CMC (Chemistry, Manufacturing, and Controls) Reports to: Manager/Group...  ...Inc. is an award winning, full-service, CRO/Contract Research Organization operating over 25 state-of-the-art laboratories across... 
    Contract work

    Frontage Laboratories

    Exton, PA
    5 days ago
  • Scientist/Sr. Scientist—Automation Location: Exton, PAFull-timeFrontage Laboratories Inc. is an award winning, full-service, CRO/Contract Research Organization operating over 25 state-of-the-art laboratories across the US, Canada and China. Our core competencies include... 
    Contract work

    Frontage Laboratories

    Exton, PA
    5 days ago
  • Senior Scientist - BiologicsLocation: Exton PAFull-timeFrontage Laboratories Inc. is an award winning, full-service, CRO/Contract Research Organization operating over 25 state-of-the-art laboratories across the US, Canada and China. Our core competencies include drug metabolism... 
    Contract work
    Work at office

    Frontage Laboratories

    Exton, PA
    4 days ago
  •  ...Description Job Description Associate Scientist (Pharmacokinetics) – Biologics Job...  ...winning, full-service, CRO/Contract Research Organization operating over 25 state-of-...  ...Key Responsibilities: Develop, optimize, and validate ligand binding assays (e.g... 
    Full time
    Contract work
    Internship

    Frontage Laboratories

    Exton, PA
    7 days ago
  • $203.78k - $339.63k

     ..., there must be robust health outcomes data to support launch optimization, reimbursement and maintain market position. Specifically, evidence...  ...sources to advise on their suitability to address given research questions. Develop a deep understanding of customers' needs,... 
    Local area
    Flexible hours

    GlaxoSmithKline

    Mont Clare, PA
    1 day ago
  • Trinseo in Exton, PA is seeking a Research Scientist (Polymers) to lead R&D portfolios and deliver innovative PMMA resins and surfaces technologies. You will collaborate with Marketing, TS&D, and Manufacturing to translate strategy into commercial programs. The role requires... 

    Trinseo

    Exton, PA
    2 days ago
  •  ...throughput liquid handlers, sequencers, or PCR platforms. Provide technical assistance for new sequencing platform search, review, optimization, and validation. Perform whole genome sequencing (WGS) on pathogenic bacteria, viruses, and fungi, including wet‑lab genomic... 
    Work experience placement
    Work at office
    Monday to Friday
    Shift work

    Centurion Health

    Exton, PA
    4 days ago
  • A national recruiting firm is seeking a Project Manager for R&D Project Management in Frazer Township, Pennsylvania. The role involves managing global product development teams and requires a Bachelor's degree in a science, healthcare discipline, or industrial engineering...

    Mindlance

    Frazer, PA
    5 days ago
  • Scientist/ Senior Scientist/ Principal Scientist, method Developer, Large Molecules Quantitation by LC-MS/MS, Bioanalytical ServicesLocation: Exton, PA (Corporate)Full timeResponsibilities:Mainly responsible for developing bioanalytical quantitation methods for large molecules... 
    Temporary work
    Work experience placement

    Frontage Laboratories

    Exton, PA
    5 days ago
  • Senior Method development scientist-Biomarker LC-MS/MSTitle: Senior method development scientist- Biomarker LC-MS/MSLocation: 700 Pennsylvania...  ...Inc. is an award winning, full-service, CRO/Contract Research Organization operating over 25 state-of-the-art laboratories across... 
    Contract work

    Frontage Laboratories

    Exton, PA
    5 days ago
  •  ...their merit.We are searching for the best talent for a Principal Scientist, In-vivo CAR-T Potency Method Development to be located in...  ...Biotechnology, Chemistry, Manufacturing, and Control (CMC), Clinical Research and Regulations, Clinical Trial Designs, Coaching, Critical... 
    Full time
    Local area

    Johnson & Johnson

    Malvern, PA
    4 days ago
  • In vitro ADME Senior/Principal Scientist - DMPKLocation: Exton, PA Department: DMPK (Drug Metabolism & Pharmacokinetics)Employment Type...  ...an award winning, publicly listed, full-service CRO/Contract Research Organization operating over 25 state-of-the-art laboratories across... 
    Contract work
    Temporary work

    Frontage Laboratories

    Exton, PA
    3 days ago
  •  ...in the Malvern, PA office. (3 days in office)The Senior Data Scientist plays a critical role within the Data Science team, driving advanced...  ...role focuses on developing strategic models and solutions to optimize business operations, enhance customer experience, and maximize... 
    Work at office

    CubeSmart Self Storage

    Malvern, PA
    1 day ago
  •  ...ROLE_DESCRIPTION - Senior AWS Data Scientist with 8+ years of experience in Machine Learning, MLOps, and GenAI, specializing in Amazon...  ..., Python, and AWS analytics services to build, deploy, and optimize scalable AI/ML solutions. AWS Data Scientist with strong expertise... 

    Diverse Lynx

    Malvern, PA
    17 hours ago
  •  ...$53–59/hr. on W2Experience: 8+ YearsWe are seeking an experienced AWS Data Scientist with strong expertise in Machine Learning, MLOps, and Generative AI to design, develop, deploy, and optimize scalable AI/ML solutions on AWS. The ideal candidate should have hands-on experience... 

    Diverse Lynx

    Malvern, PA
    5 hours ago

Do you want to receive more vacancies?

Subscribe and receive similar vacancies to Optimization Research Scientist. Be the first to apply!