Director/Senior Director/ Executive Director: Digital Innovation & Technology Strategy - Global PK/PD & Pharmacometrics

Job ID: R-99374Company: LillyLocation: Indianapolis, Indiana, United States of AmericaJob Type: Full TimeCategory: Research & DevelopmentPosted Date: 2026-02-11At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.Eli Lilly and Company is committed to using its innovation-based strategy to discover, develop and deliver innovative medicines that help improve the lives of people.The PK/PD & Pharmacometrics organization is at a pivotal moment: we're redefining how we harness decades of clinical data and model-informed drug development approaches through strategic AI and automation adoption.We are seeking a Digital Innovation & Technology Strategy Lead who will define and implement our multi-year roadmap for integrating artificial intelligence, machine learning, and automation technologies into our quantitative pharmacology and pharmacometric workflows. This role will help position us as an industry leader in AI-enabled drug development while ensuring scientific rigor, regulatory defensibility, and meaningful value creation.Key responsibilitiesDevelop and implement a comprehensive digital strategy for PK/PD & Pharmacometrics, identifying and prioritizing high-impact use cases that accelerate drug development and position PK/PD as an industry leader in AI-enabled quantitative pharmacologyLead PK/PD's digital strategy as the primary work with internal and external partners, managing collaborator relationships to accelerate value delivery from AI and automation investmentsEvaluate emerging AI technologies for clinical pharmacology and pharmacometrics applications, leading proof-of-concept pilots and scaling validated solutionsPartner with IT, data science, and data engineering teams to implement AI solutions and establish data governance standards that ensure PK/PD data is AI-ready, accessible, compliant, and coordinated with existing systems and workflowsCollaborate with project leaders, pharmacometrician's, and cross-functional partners (e.g. Clinical Operations, Statistics, Regulatory Affairs) to ensure seamless AI integration across R&D and serve as the primary voice for AI strategy within PK/PD leadership and governance forumsGrow and implement organisational change strategies to drive AI adoption, including training programs, champion networks, and upskilling resources that address resistance and build organizational capability in AI/ML methodologiesDefine success metrics and track value creation for digital/technology initiatives, maintaining a portfolio of use cases with clear ROI documentation and preparing executive-level cases and communicationsEstablish relationships with external partners (e.g. academic institutions, technology vendors, industry consortia, regulatory agencies) and contribute to thought leadership through publications and conference presentations, representing Lilly's vision for responsible AI adoptionMINIMUM REQUIREMENTS:Master’s degree in a relevant fieldMinimum 8 years of experience in pharmaceutical R&D, with at least 2 years focused on AI/ML/digital technology applications in drug developmentExperience in PK/PD modeling, pharmacometric workflows (e.g. population PK, exposure-response, dose optimization), and model-informed drug development principlesExperience implementing digital solutions in a regulated industry environmentAdditional Skills/Preferences:Familiarity with data architecture, cloud computing, and innovative analytics platformsexperience crafting compelling cases and executive-level presentationsTrack record of external thought leadership through publications, conference presentations, or industry working groupsHands-on experience with specific AI tools (e.g. Python/R/Matlab for ML, TensorFlow/PyTorch, cloud-based ML platforms)Track record of successful pilot-to-production digital scalingHands on experience with PK/PD modelling and simulation and model-informed drug developmentOther Considerations:Location: Indianapolis, IN or Boston, MA (hybrid work model available)Travel: Domestic and international travel up to 20% (conferences, vendor meetings, cross-site collaboration)Work Environment: Highly collaborative, matrixed organization requiring cross-functional relationshipsInnovation Culture: We encourage calculated risk-taking, rapid prototyping, and learning from failuresLilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form () for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is$177,000 - $308,000Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.#WeAreLillySkillsai strategy developmentpharmacometric workflowspk/pd modelingmachine learningdata governancecloud computingpythonrmatlabtensorflowpytorchdata architectureinnovative analytics platformsmodel-informed drug developmentregulatory complianceexecutive-level presentationsstakeholder managementorganizational change managementexternal partnership managementthought leadership