Software Engineer

Position Summary The C-BRAIN Data Engineer is a key technical member of the C-BRAIN team responsible for designing, building, and maintaining the data infrastructure that powers C-BRAIN's AI tools. Reporting to the C-BRAIN Chief Technology Officer (CTO), this role is responsible for all aspects of data ingestion, pipeline development, data harmonization, and cloud infrastructure management — ensuring that high-quality, analysis-ready data is available to C-BRAIN's AI tools and research teams. C-BRAIN is building an AI Biomedical Research Scientist platform that integrates diverse multi-institutional datasets (including NACC, ADNI, and consortium member data contributions). The Data Engineer will be central to building the technical infrastructure that makes this platform possible, working in close partnership with the CTO, the Senior Technical Product Manager, and external data science collaborators. This is not a standard data pipeline position. The Data Engineer is building the technical backbone of an AI biomedical research platform — infrastructure that must ingest and harmonize multi-modal neurodegeneration datasets at consortium scale and serve as the data foundation for agentic AI tools including InsightEngine and OpenScientist. The ideal candidate brings software engineering discipline, strong cloud platform experience, and demonstrated knowledge of neurodegeneration or biomedical research data. Domain knowledge is a prerequisite, not a nice-to-have; C-BRAIN-specific context will be provided, but neurodegeneration data experience and software engineering fundamentals will not. Location Remote, US Scheduled Hours 40 Job Description Primary Duties & Responsibilities Data Pipeline Development and Maintenance Designs, builds, tests, and maintains scalable data ingestion pipelines to ingest consortium member datasets from diverse sources and formats into the C-BRAIN data infrastructure. Develops and maintains ETL/ELT workflows using tools such as Apache Spark, dbt, Airflow, or equivalent; ensure pipelines are robust, well-documented, and auditable. Implements automated pipeline monitoring and alerting; troubleshoot and resolves pipeline failures in a timely manner. Works collaboratively with the CTO and data science teams to understand data requirements for AI tool development and translates those requirements into technical pipeline specifications. Maintains version control for all pipeline code and infrastructure configurations; follows software engineering best practices including code review and documentation. Integrates and processes multi-modal data including omics (genomics, transcriptomics, proteomics), neuroimaging (PET, MRI), longitudinal clinical records, and digital pathology — reconciling differences in data type, format, spatial resolution, and dimensionality into unified analytical frameworks. Identifies where cross-modal integration produces genuine signal versus where it introduces noise or artifact; establishes ground truth benchmarks for downstream AI use. Data Infrastructure and Cloud Operations Manages and optimizes the C-BRAIN data infrastructure: storage accounts, computes resources, data lakes, and access controls. Implements and maintains data access controls and permissions aligned with DUA requirements and WashU data governance policies. Collaborates with the CTO on cloud architecture decisions; contributes to infrastructure planning for Phase 2 scale-up including foundation model compute requirements. Monitors infrastructure costs, resource utilization, and performance; identifies and implements optimization opportunities. Supports the deployment of C-BRAIN AI tools on cloud-based platforms; coordinates with technical teams on infrastructure requirements. Ensures all data handling complies with DUA terms and applicable PHI de-identification requirements; implements, documents, and maintains de-identification workflows for each incoming dataset. Uploads curated datasets to ADDI/AD Workbench and other designated repositories (NIAGADS, GP2, or equivalent) as directed; manages access controls within the platform to ensure data is accessible only by authorized users and tools. Data Harmonization and Quality Develops and implements data harmonization procedures to integrate datasets from multiple sources (NACC, ADNI, consortium member contributions) into a unified, analysis-ready format. Implements data quality validation checks at ingestion and transformation stages; documents data quality issues and coordinates resolution with data providers. Maintains comprehensive data lineage documentation: tracks data from source to consumption, documents all transformations, and ensures reproducibility. Collaborates with research scientists and the AD, Scientific to understand scientific data requirements and ensures data products meet research use case specifications. Aligns incoming datasets to established biomedical data standards including AD Workbench, ADDI, NIAGADS, and GP2; builds and maintains data dictionaries and metadata records for each ingested dataset. DUA Technical Support and Data Delivery Provides technical input on Data Use Agreements: defines technical specifications for data format, delivery method, transfer protocols, and storage requirements in coordination with the Senior Technical Product Manager. Confirms receipt of contributed datasets, validates format and completeness against DUA specifications, and logs acceptance in the DUA register. Flags data quality, completeness, or format issues to the Senior Technical Product Manager and CTO for follow-up with data contributors. Supports technical aspects of the data delivery monitoring process: tracks expected deliveries, confirms receipt, and maintains data delivery logs. Supports beta testing of data ingestion tools and provides structured feedback to development partners; maintains clear, reproducible documentation so pipeline processes can be audited and transferred. Documentation and Reporting Maintains comprehensive technical documentation for all pipelines, infrastructure configurations, and data architecture decisions in the C-BRAIN documentation repository. Develops and maintains a C-BRAIN data catalog: documents available datasets, data dictionaries, lineage, and access procedures. Contributes technical content to C-BRAIN progress reports, Steering Committee materials, and grants reporting as requested by the CTO or Senior Technical Product Manager. Working Conditions Job Location/Working Conditions Normal office environment Occasional on-site presence required for in-person meetings, team meetings, and consortium events. Physical Effort Typically working at desk or table Repetitive wrist, hand or finger movement Ability to move to on and off-campus locations Primarily sedentary with standard computer use. Equipment Office equipment The above statements are intended to describe the general nature and level of work performed by people assigned to this classification. They are not intended to be construed as an exhaustive list of all job duties performed by the personnel so classified. Management reserves the right to revise or amend duties at any time. Required Qualifications Bachelor's degree in Computer Science, Data Science, Bioinformatics, Engineering, or a closely related field. Three years of hands-on data engineering experience, including design and development of data pipelines and ETL/ELT workflows in a production or research environment. Demonstrated proficiency in Python and SQL. Experience with cloud data platforms: Microsoft Azure preferred (AWS or GCP also acceptable). Familiarity with cloud storage, compute, and access control management. Experience working with complex, multi-source datasets requiring integration, harmonization, and quality validation. Demonstrated software engineering background: production-grade Python with version control (Git), code review practices, and automated testing. This role requires engineering discipline and the ability to build maintainable, auditable code — scripting proficiency alone is insufficient. Experience working with at least two of the following biomedical data modalities: omics (genomics, transcriptomics, proteomics), neuroimaging (PET, MRI), digital pathology, or longitudinal clinical/EHR data. Demonstrated experience working with neurodegeneration or Alzheimer’s disease research datasets. Familiarity with the neurodegeneration data landscape — NACC, ADNI, and/or AD/ADRD repositories — and sufficient understanding of the biological context to communicate meaningfully with research scientists. Biomedical informatics experience without neurodegeneration domain knowledge is insufficient for this role. Preferred Qualifications Experience working with biomedical, clinical, or research datasets in an academic medical center, research university, or life sciences organization. Experience with research data repositories such as ADDI, Synapse, Terra, or NACC/ADNI data platforms. Experience with one or more of: Apache Spark, dbt, Airflow, Azure Data Factory, or equivalent ETL/ELT frameworks. Familiarity with data governance frameworks, data use agreements, or federated data architectures. Experience supporting AI/ML or data science teams as a data engineering partner: understanding how data products are consumed by model training and inference pipelines. Experience with NAIRR or other research cloud computing platforms. Experience with data catalog tools, data lineage platforms, or metadata management. Familiarity with de-identification standards and privacy-preserving data techniques relevant to biomedical research. Master’s or PhD in Computer Science, Data Science, Bioinformatics, Biomedical Informatics, or a related field. Familiarity with agentic AI frameworks and how curated datasets feed retrieval-augmented generation (RAG) or LLM-based co-scientist systems (e.g., LangGraph, DSPy, or equivalent). Experience with NLP techniques relevant to biomedical data: named entity recognition, natural language inference, or knowledge graph construction. Knowledge of graph data structures and graph platforms (Neo4j, Amazon Neptune, or equivalent) for representing multi-modal biomedical relationships. Track record of cross-disciplinary collaboration between computational and experimental or clinical teams. Metadata Repository Cloud Computing Platform Computer Science Data Engineering Federated Identity Management Research Databases Grade G14 Salary Range $75,200.00 - $128,800.00 / Annually The salary range reflects base salaries paid for positions in a given job grade across the University. Individual rates within the range will be determined by factors including one's qualifications and performance, equity with others in the department, market rates for positions within the same grade and department budget. Questions For frequently asked questions about the application process, please refer to our External Applicant FAQ. Accommodation If you are unable to use our online application system and would like an accommodation, please email View email address on click.appcast.io or call the dedicated accommodation inquiry number at View phone number on click.appcast.io and leave a voicemail with the nature of your request. All qualified individuals must be able to perform the essential functions of the position satisfactorily and, if requested, reasonable accommodations will be made to enable employees with disabilities to perform the essential functions of their job, absent undue hardship. Pre-Employment Screening All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening. Benefits Statement Personal Up to 22 days of vacation, 10 recognized holidays, and sick time. Competitive health insurance packages with priority appointments and lower copays/coinsurance. Take advantage of our free Metro transit U-Pass for eligible employees. WashU provides eligible employees with a defined contribution (403(b)) Retirement Savings Plan, which combines employee contributions and university contributions starting at 7%. Wellness Wellness challenges, annual health screenings, mental health resources, mindfulness programs and courses, employee assistance program (EAP), financial resources, access to dietitians, and more! Family We offer 4 weeks of caregiver leave to bond with your new child. Family care resources are also available for your continued childcare needs. Need adult care? We’ve got you covered. WashU covers the cost of tuition for you and your family, including dependent undergraduate-level college tuition up to 100% at WashU and 40% elsewhere after seven years with us. For policies, detailed benefits, and eligibility, please visit: EEO Statement Washington University in St. Louis is committed to the principles and practices of equal employment opportunity. It is the University’s policy to provide equal opportunity and access to persons in all job titles without regard to race, ethnicity, color, national origin, citizenship (where prohibited by federal law), age, religion, sex, sexual orientation, gender identity or expression, disability, protected veteran status, or genetic information. #J-18808-Ljbffr