Senior/ Principal Scientist

Job Description

Company Description Cime Therapeutics is a next-generation tech bio company that integrates synthetic chemistry, AI/ML, and automation to transform drug discovery. The organization has developed proprietary chemistry technology that enables faster, multi-step synthesis of complex molecules, providing a unique advantage in the industry. By combining multi-step synthesis and screening into a unified workflow, Cime accelerates the Design-Make-Test-Analyze cycle. Team members collaborate across scientific and technical disciplines to rapidly explore chemical space and advance therapeutic candidates.

Role Description The Senior/Principal Scientist will lead experimental design and execution to support Cime’s integrated synthesis and screening platform in an on-site, full-time role based in Boulder, CO. Responsibilities include planning and performing complex multi-step syntheses, optimizing reaction conditions, and analyzing results to inform iterative design of novel molecules. The scientist will align chemistry efforts with AI/ML-driven design and high-throughput screening strategies. Day-to-day activities involve generating and interpreting data, troubleshooting experiments, documenting methods and results, and presenting findings to internal stakeholders. This is a lab based position.

Qualifications

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• Ph.D. in Chemistry with 0-4 years experience or equivalent industry experience; prior experience in pharma, biotech, or tech bio organizations is highly beneficial.
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• Advanced expertise in synthetic organic chemistry and complex multi-step synthesis, with a strong track record of designing and executing challenging synthetic routes.
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• Experience with analytical techniques such as NMR, LC/MS, HPLC, and chromatography for purification and characterization of small molecules.
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• Background collaborating with or leveraging computational tools, AI/ML approaches, or automation platforms to support chemistry or drug discovery workflows.
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• Demonstrated ability to design experiments, interpret data critically, troubleshoot issues, and iterate rapidly in a discovery setting.
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• Strong scientific communication skills, including clear documentation of methods, preparation of reports, and presentation of results to diverse technical audiences.
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• Proven experience working in cross-functional teams and mentoring or guiding junior scientists in a laboratory environment.
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• Commitment to safety, quality, and reproducibility in laboratory operations, with the ability to thrive in a fast-paced, innovative environment.
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Compensation & Benefits

Cime Therapeutics offers a competitive compensation package and the opportunity to make a meaningful impact at an early-stage biotechnology company.

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• Base Salary: $100,000–$140,000 annually, depending on qualifications, experience, and demonstrated scientific expertise.
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• Performance Bonus: Potential eligibility for a discretionary bonus based on individual and company performance. Bonuses are not guaranteed.
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• Retirement: 401(k) retirement plan with a safe harbor employer contribution.
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• Paid Holidays: Company-observed paid holidays.
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• Paid Sick Leave: Paid sick leave in accordance with Colorado law.
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The position will be leveled as Senior Scientist or Principal Scientist based on the candidate's experience, technical expertise, and demonstrated scientific leadership.

Interested candidates should submit a CV by emailing info at cimetherapeutics.com

Cime Therapeutics is committed to building a collaborative, innovative, and inclusive team. We welcome applications from scientists with diverse backgrounds and experiences who are passionate about advancing the future of chemistry and drug discovery.