Lab Technician

About Eon Eon is building large-scale connectomic data collection systems to enable safe and scalable brain emulation technology. Our mission is to help bring human intelligence into the digital age. We are looking for a scientist to help build robust tissue processing and expansion microscopy pipelines for high-resolution volumetric imaging of mammalian brain tissue. The Opportunity As the Lab Lead, you will be the backbone of Eon’s tissue processing and lab operations. You will be responsible for overseeing day-to-day laboratory workflows, supporting the development and execution of robust tissue-processing pipelines, and ensuring that the team has the materials, tools, documentation, and operational systems needed to maintain high standards of quality, reproducibility, and throughput. This role is ideal for a highly organized, hands-on individual with a strong foundation in laboratory operations, tissue processing, and workflow management. You should have a keen eye for operational efficiency, strong scientific judgment, and an eagerness to take ownership of complex, mission-critical processes. As a core member of a fast-moving company, you will have the chance to contribute beyond a narrow job description. We value team members who take initiative, are eager to learn new skills, and are willing to wear multiple hats to help drive our broader mission forward. This is a role with real opportunity to make a tangible impact on Eon’s core imaging workflows and the systems that support them. Work Hours: In-person full-time, Monday to Friday, standard business hours, with some flexibility required to support operations. Key Responsibilities Lab Operations & Workflow Management: Streamline and manage end-to-end laboratory workflows related to tissue processing, staining, expansion microscopy, and sample preparation. Ensure smooth execution, strong coordination across teams, and reliable handoff into downstream imaging workflows. Lab Management & Supervision: Take ownership of day-to-day lab operations, including maintaining lab organization, supporting team execution, managing priorities, and ensuring the lab adheres to safety, cleanliness, and quality standards. Tissue Processing & Pipeline Support: Lead and improve the processing, staining, and preparation of mammalian brain tissue for high-resolution volumetric optical imaging. Help develop robust and reproducible workflows that integrate cleanly into Eon’s broader imaging pipeline. Inventory & Procurement: Manage and optimize inventory systems for reagents, consumables, antibodies, stains, and other critical supplies. Forecast needs, coordinate procurement, and ensure uninterrupted lab operation. Equipment, Maintenance & Systems: Oversee instrument upkeep, maintenance schedules, and day-to-day readiness of lab infrastructure. Support standardized equipment documentation, process consistency, and reliable system performance. Documentation, SOPs & Process Standardization: Maintain meticulous and organized records of protocols, experiments, workflow changes, and operational updates. Draft, refine, and maintain SOPs, work instructions, checklists, and training materials to support reproducibility, adoption, and long-term sustainment. Cross-Functional Collaboration: Work closely with researchers, animal teams, microscopy teams, and engineering teams to improve upstream and downstream pipeline performance. Clearly communicate progress, challenges, and process updates in a structured way. Operational Tracking & Continuous Improvement: Track workflow performance, process gaps, risks, and decisions. Produce clear summaries and basic metrics related to throughput, training coverage, SOP updates, and operational readiness. Help define more standardized future-state workflows as the lab scales. What You’ll Work On Your work may include: optimizing staining of large mammalian neural tissue for strong, reproducible signal quality developing and improving expansion microscopy pipelines for large tissue samples refining tissue processing methods to improve quality, consistency, and throughput executing signal amplification strategies to improve signal-to-noise ratio validating antibodies and other staining reagents for use in neural tissue characterizing processed tissue using fluorescence microscopy and integrating samples into volumetric imaging workflows collaborating across teams to improve upstream and downstream pipeline performance developing new protocols for thick tissue staining, section handling, and whole-brain processing managing reagent, consumable, and sample flow systems to support reliable lab execution standardizing documentation, SOPs, and training materials to enable consistent adoption across workflows About You We are looking for someone with strong scientific judgment, high agency, and deep comfort working in a fast-moving experimental environment. You should be excited by the idea of building new workflows rather than just running established ones. The right person for this role is detail-oriented, highly hands-on, and motivated by the challenge of making complex biological systems more reliable and scalable. You are also highly organized, process-oriented, and comfortable taking ownership over both experimental execution and the operational systems that support it. You thrive in cross-functional environments, communicate clearly, and are motivated by improving quality, consistency, and scale. Qualifications & Skills Required: BSc or MSc in neuroscience, biology, bioengineering, biomedical engineering, molecular biology, chemistry, or a related field, or equivalent practical experience 1–3+ years of hands‑on experience in a molecular biology, neuroscience, tissue processing, or imaging-focused laboratory Strong hands‑on experience with neural tissue processing, staining, immunofluorescence, and microscopy-based workflows Strong organizational skills, meticulous attention to detail, and a process-oriented mindset Excellent problem-solving skills and the ability to work both independently and as part of a collaborative team Strong experimental judgment and comfort iterating on protocols in a fast-moving research environment Ability to manage multiple priorities and maintain operational clarity in a high-growth environment Demonstrated ability to learn quickly, take ownership, and contribute across functions Preferred: Experience with tissue-processing methods for high-volume, high-resolution imaging, such as expansion microscopy, CLARITY, or related approaches Familiarity with neuroanatomy and preservation of tissue architecture Understanding of fluorescence, fluorophore labeling chemistry, and signal amplification methods Ability to perform basic bioconjugation chemistry Familiarity with standard and advanced fluorescence microscopy techniques, including confocal and light-sheet microscopy Experience managing lab logistics, inventory systems, or operational workflows Experience drafting or maintaining SOPs, work instructions, checklists, or training materials Experience standardizing workflows, improving data quality, or supporting process adoption across teams Experience with laboratory automation or liquid handling systems Experience in a startup or other fast-paced environment Experience working closely with microscopy, animal, or engineering teams in a cross-functional setting Example Projects Examples of projects you may work on include: developing protocols for staining neural tissue samples greater than 1 mm with antibodies and small-molecule stains regularly performing expansion microscopy on tissue samples and improving the robustness of the workflow processing mammalian brain tissue at scale for microscopic analysis improving the preparation or synthesis of staining reagents with stronger fluorescent signal building a tissue-preparation pipeline that feeds directly into large-scale connectomic imaging standardizing current-state lab workflows and helping implement more scalable future-state operational practices drafting and updating SOPs, work instructions, and lab training materials to support consistency and adoption improving inventory, documentation, and workflow tracking systems to enable reliable day-to-day lab performance Compensation Competitive salary based on experience, initiative, leadership skills, and independent work. #J-18808-Ljbffr