Postdoctoral Fellow-MSH-30035-400

Description Salary: $74,692 Department: Neuroscience Physical work location: 1415 Madison Avenue, 10-20A, New York, NY 10029 Name PI or Supervisor: Daniel Almeida da Silva e Silva, View phone number on click.appcast.io, View email address on click.appcast.io Web link to Lab: dasilvalab.org Web link to Department: Administrative Contact: View phone number on click.appcast.io, View email address on click.appcast.io Responsibilities Details of Research Project: We will investigate the role of Sirt7, a histone deacetylase, in D1-type medium spiny neurons (D1-MSNs), focusing on how it shapes synaptic plasticity and modulates resilience to compulsive alcohol drinking. Our central hypothesis is that that epigenetic changes in D1-MSNs of the dorsomedial striatum, driven primarily by histone acetylation and modulated by Sirt7, promote transcriptional and synaptic adaptations that jointly confer resilience to compulsive-like drinking. The rationale for this project is grounded in compelling preliminary data suggesting that transcriptional changes in the histone acetylation process, particularly those regulated by Sirt7, are associated with reduced compulsive-like drinking in mice through the transcriptional control of synaptic pathways. Technical Duties: (include any protocols) Responsibilities will include conducting alcohol-related behavioral experiments, including operant self-administration and other drinking paradigms; maintaining and managing mouse colonies; performing stereotaxic surgeries and related experimental procedures; monitoring animals throughout behavioral studies; and collecting brain tissue for downstream molecular and cellular analyses. Qualifications Educational and other Requirements for the position: PhD in Biological Science Experience Required: At least 5 years of experience working with laboratory mice, including mouse handling and behavioral experiments. Goals/Outcomes of the Research Project: Identify mechanisms that promote resilience to compulsive alcohol drinking, a clinically relevant phenotype of AUD characterized by continued drinking despite adverse consequences. Employer Description Strength through Unity and Inclusion The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinai’s unparalleled legacy of achievement, education, and innovation as we work together to transform healthcare. We encourage all team members to actively participate in creating a culture that ensures fair access to opportunities, promotes inclusive practices, and supports the success of every individual. At Mount Sinai, our leaders are committed to fostering a workplace where all employees feel valued, respected, and empowered to grow. We strive to create an environment where collaboration, fairness, and continuous learning drive positive change, improving the well-being of our staff, patients, and organization. Our leaders are expected to challenge outdated practices, promote a culture of respect, and work toward meaningful improvements that enhance patient care and workplace experiences. We are dedicated to building a supportive and welcoming environment where everyone has the opportunity to thrive and advance professionally. Explore this opportunity and be part of the next chapter in our history. About the Mount Sinai Health System: Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time - discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes more than 9,000 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. 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Compensation The Mount Sinai Health System (MSHS) provides salary ranges that comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $72500 - $80000 Annually. Actual salaries depend on a variety of factors, including experience, education, and operational need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits. #J-18808-Ljbffr Mount Sinai