Principal Scientist, Large Molecules Mass Spectrometry

Organization Overview The Bioanalytical Research Group (BAR) at Lilly’s research facility in Indianapolis, IN is seeking a strong scientist skilled in protein and oligonucleotide mass spectrometry to deliver innovative ways in our evaluation of the ADME properties of therapeutic proteins and genetic medicine modalities. The team collaborates with Investigative ADME, Toxicology, Oncology, and Biotechnology Discovery Research to discover and characterize optimal therapeutic candidates to advance to clinical testing. Primary Responsibilities The development and application of QQQ and high-resolution LC/MS approaches to characterize the PK, biotransformation, and biodistribution of therapeutic proteins and new drug modalities in pre‑clinical animal models. Serving as the bioanalytical representative with project teams to achieve project milestones. Prioritization of workload and mentoring staff scientists within a broad field bioanalytical team. Job Requirements M.S. in biochemistry/molecular biology, bioengineering, biology, pharmacology, chemistry, or equivalent field and 4+ years of work experience (or a B.S. with 6+ years). Experience developing and implementing orbitrap mass spectrometry applications to investigate the ADME properties of therapeutic proteins and new modalities (Large Molecules). Experience with wet biochemistry and sample preparation techniques involved in isolating biotherapeutics from biological matrices. Qualified applicants must be authorized to work in the United States on a full‑time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1. Preferred Qualifications Expertise in bioanalysis of siRNA or Antibody‑Oligonucleotide Conjugates (AOC) is highly preferred. Experience assessing PK, Efficacy, and toxicology profiles in preclinical models and presenting data to project teams is highly desirable. Knowledge of the ADME principles of biotherapeutic drugs. Experience with proteomics methods, DDA, nano‑LC, DIA, or similar workflows in a drug discovery setting. Additional experience with automation, higher throughput methodologies, and biotransformation software tools. Excellent written and verbal communication skills. Strong work planning, record keeping and data analysis skills. Compensation and Benefits $65,250 - $193,600 Full‑time equivalent employees will also be eligible for a company bonus (depending, in part, on company and individual performance). Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company‑sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well‑being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities). Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees. Equal Opportunity Employment Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. #J-18808-Ljbffr