Clinical Laboratory Scientist, (Technical Supervisor)

About The Role:
10x Genomics is establishing a diagnostics effort to translate our leading single-cell and spatial genomics technologies into impactful clinical applications. This Clinical Laboratory Scientist/Technical Supervisor position performs and provides scientific and technical oversight for high complexity next-generation sequencing (NGS) assays within a CLIA-certified laboratory. This role is accountable for ensuring the operational execution, analytical validity, performance, and regulatory compliance of all NGS testing. The Technical Supervisor serves as the subject matter expert for assay validation, quality systems, and troubleshooting, and partners closely with laboratory leadership to maintain operational excellence and continuous improvement.

What You Will Be Doing:

• Provide operational execution and technical oversight of high complexity NGS assays, ensuring analytical accuracy and reliability of test results.
• Validate, and implement NGS assays in accordance with CLIA, CAP, and applicable regulatory standards.
• Establish and monitor quality control (QC) and quality assurance (QA) programs, including review of performance metrics, trends, and corrective actions.
• Author, review, and approve technical documentation, including standard operating procedures (SOPs), validation protocols/reports, and test methods.
• Ensure compliance with all regulatory requirements and support internal and external audits and inspections.
• Serve as the primary technical resource for troubleshooting complex assay, instrumentation, and bioinformatics issues.
• Evaluate and approve changes to assays, workflows, instrumentation, and software, including revalidation as required.
• Oversee proficiency testing, method comparisons, and ongoing assay performance monitoring.
• Provide technical training and competency assessment for laboratory personnel.
• Collaborate with cross-functional teams (bioinformatics, R&D, quality, and operations) to support assay optimization and innovation.
• Stay current with emerging technologies, regulatory updates, and best practices in NGS and molecular diagnostics.

To Be Successful in this Role, You Will Need:

• Active California Clinical Laboratory Scientist (CLS) license meeting CLIA requirements for Technical Supervisor of high complexity testing.
• Meets CLIA Technical Supervisor qualifications under 42 CFR 493.1449, including appropriate education, training, and experience
• Bachelor's degree in chemical, biological, physical, clinical laboratory science, or a related field.
• Minimum of 4-6 years of experience in CLIA lab molecular diagnostics, with significant experience in NGS assay validation, implementation, and operation
• Demonstrated expertise and experience in NGS technologies, including library preparation, sequencing platforms, and bioinformatics analysis pipelines
• Strong knowledge of CLIA, CAP, NYS, and other regulatory frameworks governing high complexity testing.
• Proven experience with assay validation, QC/QA systems, and regulatory inspections.

Additional attributes

• Prior experience serving as CLIA Technical Supervisor
• Startup or high growth laboratory experience
• Background in medical or oncology diagnostics
• Excellent analytical, problem-solving, and decision-making skills.
• Strong written and verbal communication skills, with the ability to convey complex technical concepts clearly.

Below is the base pay range for this full-time position. The actual base pay will depend on several factors unique to each candidate, including one's skills, qualifications, and experience. At 10x, base pay is also just one component of the Company's total compensation package. This role is also eligible for 10x's equity grants, its comprehensive health and retirement benefit programs, and its annual bonus program or sales incentive program. During the hiring process, your 10x recruiter can share more about the Company's total compensation package.

Pay Range

$158,400-$214,400 USD

About 10x Genomics

At 10x Genomics, accelerating our understanding of biology is more than a mission for us. It is a commitment. This is the century of biology, and the breakthroughs we make now have the potential to change the world.

We enable scientists to advance their research, allowing them to address scientific questions they did not even know they could ask. Our tools have enabled fundamental discoveries across biology including cancer, immunology, and neuroscience.

Our teams are empowered and encouraged to follow their passions, pursue new ideas, and perform at their best in an inclusive and dynamic environment. We know that behind every scientific breakthrough, there is a deep infrastructure of talented people driving the life sciences industry and making it possible for scientists and clinicians to make new strides. We are dedicated to finding the very best person for every aspect of our work because the innovations and discoveries that we enable together will lead to better technologies, better treatments, and a better future. Find out how you can make a 10x difference.


Individuals seeking employment at 10x Genomics are considered without regards to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation, or any other characteristic protected by applicable law.

10x does not accept unsolicited applicants submitted by third-party recruiters or agencies. Any resume or application submitted to 10x without a vendor agreement in place will be considered unsolicited and property of 10x, and 10x will not pay a placement fee.

Please be aware of recruitment scams impersonating 10x Genomics. All recruiting communication will come from email addresses @10xgenomics.com. We also want to encourage you to apply to 10x Genomics positions directly on our careers site, Careers.10xgenomics.com or from reputable third party sites, such as LinkedIn or Indeed. We will never request payment or sensitive personal information during the recruiting process.