Lead System Engineer
System One Holdings, LLC
Lead System EngineerOnsite, Pittsburgh, PA 15213 Type: 6-month contract to hireOverview: Join a cutting-edge lab to discover novel therapeutics that are seeking a highly motivated Lead System Engineer to support the development, integration, and operation of advanced aerosol delivery, sensing, and exposure systems for human-relevant experimental platforms. This role focuses on ensuring precise, reproducible generation and delivery of airborne agents, as well as integration of instrumentation and multi-system platforms to enable controlled and standardized experimental workflows. The position will contribute to system optimization, performance validation, and operational readiness in complex laboratory environments.Responsibilities:Design, prototype, and refine biomedical devices and components supporting advanced experimental systemDevelop and optimize fabrication processes to ensure consistency, quality, and scalabilityContribute to selection and evaluation of materials, fabrication methods, and assembly workflowsPerform testing and validation of device performance, including durability, reproducibility, and functional integrityCollaborate with scientific and engineering teams to align device design with experimental requirementsMaintain documentation related to design iterations, fabrication processes, and quality controlTroubleshoot device-related issues and implement design improvementsSupport coordination of engineering activities across multidisciplinary teams and contribute to project executionContribute to preparation of technical documentation, reports, and related materialsRequirements:Bachelor's degree in Biomedical Engineering, Mechanical Engineering, Electrical / System Engineering, or a related fieldMinimum of 3 years of relevant experience in device design, prototyping, or fabricationExperience with engineering design tools (e.g., CAD software)Strong problem-solving skills and attention to detailAbility to work effectively in multidisciplinary research and engineering environmentsPreferred Qualifications:Master's or Ph.D. in a relevant engineering disciplineExperience with fabrication of small-scale or precision-engineered devices, including Organs-on-Chips, injection molding, and CNC millingFamiliarity with polymer-based materials and manufacturing processesExperience with iterative prototyping and design-for-manufacturing principlesExperience working at the interface of engineering and biological systems
$91.1k - $129.8k
...solutions and innovative technologies that improve reliability, sustainability, and performance.How will you make a difference? The Lead Systems Engineer, MCA - Will partner with a team of engineers focused on delivering software solutions for Wabtec’s growing fleet of MCA...SuggestedWork experience placementWorldwide$162.01k - $185.16k
STV is seeking a CBTC & Next Gen Engineering Director to join our Systems Department in our Pittsburgh, PA office.This senior leadership position will... ...a recognized technical authority and trusted advisor, leading multidisciplinary teams responsible for the planning, design...SuggestedFull timeFor contractorsWork at officeFlexible hours- ...Departments of Medicine and Bioengineering is seeking a highly motivated Lead Research Engineer to support the development, integration, and operation of advanced aerosol delivery, sensing, and exposure systems for human-relevant experimental platforms. This role focuses on...SuggestedWork at office
$86.25k - $158.13k
...opportunity to contribute to the company’s success. As a Software Engineer Lead within PNC's IT Site Reliability Engineering Center (SRC), you... ...rotational support team which may include resolving critical systems issues during off hours. PNC is an in-office company that...SuggestedFull timeTemporary workPart timeWork experience placementWork at office- ...CISCO UCS, and more. Position Title: Server Engineer 2Business Unit: TechnologyReports to:... ...and network analysis, network operating systems, reporting and logging. Collaborates on defining... ...replication and disaster recovery. Leads complex strategic initiatives, patching and...SuggestedFull timeWork at officeWeekend workDay shift
- Systems Engineer, Servers/Cloud/DataLocation: Must be able to work onsite Tue, Wed, & Thursday out of one of these office locations: New York... ...and operate scalable, secure compute platforms. This role will lead implementation of identity management, container orchestration...Work at office
$142.7k - $158.3k
Basic Qualifications Requires a Bachelor’s degree in Systems Engineering, or a related Science, Engineering, Technology or Mathematics field... ...Design, Development or I&TWhat sets you apart:Success leading the systems development life cycle with strong proficiency with...Work experience placementFlexible hours- At the National Robotics Engineering Center (NREC), it is our engineers and technicians who... ...environment where you can sharpen your skills, lead impactful projects, and take control of... ...development.We are seeking a dynamic Systems Engineer to collaborate with team...Full timeWork experience placementFlexible hours
- ...millions depend on daily - rail transportation systems that can't afford to fail. We're more... ...than a job: a missionAs an Interface Engineer in Pittsburgh, you will play a pivotal role... ...subsystems in automated transit systems.Lead cross-discipline reviews to drive design...Worldwide
$89k - $152k
...0 Job Description: Motive Workforce is hiring a Senior Systems Engineer for an advanced manufacturing organization based in New Kensington... ...sites. You will own complex technical escalations, lead infrastructure projects, and build secure, scalable systems across...Local areaRemote workRelocation- ...facilities in Los Angeles and Greensburg, PA, is part of the Power Systems business unit, in the Industrial Performance Group of the... ...exceeding expectations of quality and service. The System Studies Engineer I will be responsible for providing System Studies for the...Full timeCasual workInternshipFlexible hours
- Role DescriptionWe are seeking an experienced Senior Java Developer with 8-10 years of experience in designing, developing, and delivering enterprise-grade applications. The ideal candidate will play a key role in building scalable, secure, and high-performance cloud-native...
$130k - $250k
...time, DayPosted: 2026-04-03Base Salary Min: 130000Corporate Engineering - Fraud Hub Lead EngineerAt BNY, our culture allows us to run our company... ...financial services company at the heart of the global financial system, we influence nearly 20% of the world’s investible assets....Full timeTemporary workWorldwideFlexible hours$102.2k - $149k
...OpportunityWSP is seeking a credentialed Professional Engineer in the Mechanical, Electrical, Plumbing (... ..., managing, and assessing facility systems and components. This role requires... ...knowledge in mechanical systems. Candidates will lead Facility Condition Assessment projects...Local areaFlexible hours$110k - $125k
...g. H1B, TN, STEM, OPT, etc.) either now or in the future.Job Summary The IT Senior Systems Engineer is a trusted technology leader to the Global IT organization, responsible for leading the implementation, maintenance, and ongoing optimization of enterprise infrastructure...Minimum wageOngoing contractH1bLocal areaRemote workWorldwide- ...Lead Software Engineer Location: Remote | Pittsburgh-area candidates preferred Work Model: Approximately 2 days onsite per month in the Robinson, PA area About eNGINE eNGINE builds Technical Teams. We are a Solutions and Placement firm shaped by decades...Full timeRemote workRelocation
$113.2k - $188.8k
...Sr. Drive Systems EngineerThe Sr. Drive Systems Engineer's primary responsibility is to lead multi-discipline teams of engineers and suppliers to execute large industrial applications of variable speed drive (VSD) and power semiconductor systems in accordance with GEV...Contract workRelocation package- ...IKOS is a leading consulting firm specialized in railway engineering. We are committed to the ecological transition and development of safe , sustainable... ...'s degree in Engineering (Mechanical, Electrical, Systems Engineering, or related discipline). Experience...Full timeWorldwide
$103.2k - $129k
...of diversity in the global workplace. As a Principal Fluid Systems Engineer you will be responsible for the design development and maintenance... ...personnel in various design and analysis efforts Lead small teams (3-5 people) on projects Communicate nature and...RelocationFlexible hours2 days per week- ...your future as we are, join our team.KPMG is currently seeking a Lead Engineer I, Tech Product Manager to join our Digital Nexus Technology... ...troubleshooting skills with MID Servers, connectivity, and system performanceUnderstanding of IT Asset Management (ITAM) and Vulnerability...H1bLocal area
$94.4k - $293.8k
We are:Accenture helps the world's leading enterprises reinvent by building their digital... ...and Enterprise, Song, Supply Chain and Engineering, and Talent, with advanced capabilities... ...technical authority for service information systems, bridging the gap between engineering,...Work experience placementLive inWork at officeLocal area- ...millions depend on daily - rail transportation systems that can't afford to fail. We're more... ...seek a passionate Safety and Reliability Engineer in Pittsburgh to drive the design and... ..., and problem-solving skills; ability to lead small teams and drive results.How Success...Worldwide
$144k - $192k
Mission Summary:We are looking for a Machine Learning Systems Engineer to join our ML Acceleration team. In this role, you will be responsible for the core systems that enable our researchers to train frontier models at scale, focusing obsessively on speed, cost, reliability...Work at officeRemote work- Work Flexibility: Field-basedAs a Staff Sales Systems Engineer at Stryker, you will be responsible for actively leading the technology evaluation stage of the sales process, working with the extended sales team as the key technical advisor and product advocate. You will...Full timeFor contractorsWork experience placement
$128k - $252.5k
Position Summary US-E - Consulting - Lead Integration Engineer II - AI & Engineering/EaaS Join our AI & Engineering team in transforming... ...capabilities, ensuring secure and efficient communication between systems (REST/SOAP). EDI Implementation & Management: Implement and...Local areaVisa sponsorshipFlexible hours- ...directly to what ships.Design and build AI systems end to end: RAG architecture, agentic orchestration, prompt & context engineering, evals & guardrails, tool-use patterns, and... ...with minimal oversight and proven ability to lead workstreams and meet deadlines, or relevant...Live inWork at officeLocal area
- ...over $2.8 billion in annual sales and a commitment to its workforce, Kokosing is the winning team.Job Description:We are seeking a Lead Engineer (Heavy Highway - Roadway/Bridge projects) in the Western PA or Morgantown area.Summary:Working onsite with the Team to plan,...Full timeContract workFor contractorsFor subcontractorWork at office
$92.3k - $166.85k
We are seeking a Lead Transmission Line Engineer who will manage a collaborative and dynamic team working in a fast-paced environment, solving challenging... ...line design projects of overhead and underground systems for some of the largest utilities in the country as well...Full timeWork at officeRemote workHome officeRelocation packageFlexible hours$128k - $252.5k
Position Summary Build and lead mobile engineering efforts that support personalized marketing, customer engagement, and digital commerce experiences. This role is suited for a mobile engineer generalist with deep experience in iOS engineering and the ability to...Local areaVisa sponsorship- ...Lead Senior Engineer 100% REMOTE SUMMARY: The Lead Senior Engineer is responsible for applying software engineering techniques and industry... ...testing and maintaining moderately complex applications andor systems. This role will collaborate with Business Analysts and Developers...Remote workFlexible hours
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