Chief of Staff, CEO
$300 per monthEdison Scientific
About Us Edison Scientific builds and deploys AI scientist agents to accelerate science and the development of new medicines. We are an ambitious team run by scientists and engineers from leading institutions across biology, physics, chemistry, and AI. Role This is Chief of Staff to Sam Rodriques, Edison Scientific's co-founder and CEO. This role is one of the highest-leverage seats in the company: you will sit next to Sam, with a front-row view of how Edison is built and how we are accelerating science. That means running Sam's most critical meetings, owning the projects that fall between teams, and keeping the machine around the CEO tight and fast. You will be the person who makes sure the most important work at Edison actually moves. While at times the job may seem mundane, it means giving you access to—and oftentimes a voice in—conversations and people far beyond what your tenure anywhere else would allow. Two things matter more than anything else. First, you have to be genuinely bought into Sam and where he is taking Edison. You will carry his thinking into rooms, sometimes to people who disagree. That only works if you believe it. Second, you must have a passion and genuine curiosity for science. This is an absolute-must. We think of this as a roughly 18‑month commitment, and later a launchpad into another senior role at Edison or somewhere else. The role is in our San Francisco office in Dogpatch five days per week. Responsibilities Run the operating cadence — board prep, executive staff, planning, and KPI reviews — so decisions get made and priorities stay clear across the company. Drive CEO communications: Partner closely on everything CEO-facing. Internal: all‑hands, company emails, employee recognition. External: prep for interviews, talks, and speeches. Special projects and strategic support: Take on some of the company's most important cross‑functional work that either has no clear owner or where the current owner isn't getting the result Sam needs. Own it end‑to‑end and drive it to completion. Design and master the support engine around Sam: Make sure everything around the CEO runs smoothly, and step in to unblock when they do not. Requirements 3+ years of strategic business experience, preferably at a high‑growth tech startup, finance or consulting. High‑agency and low‑ego. You figure out what's needed and just do it. Exceptional organization and follow‑through. Nothing falls through the cracks. Strong written and verbal communication. You can write in Sam's voice and speak clearly to anyone from a scientist to a customer to an investor. Comfort in high uncertainty. You get things done without a playbook and without close oversight. AI fluency and enthusiasm — you actively use AI to create leverage in your work and are excited about where it's headed (formal AI experience not required). Willingness to commit ~18 months in this role. Experience in a demanding, fast‑moving environment (high‑growth startup, consulting, finance, operating roles, or similar). Bonus points for Bachelor’s in biology or other scientific fields. Prior founder, or early‑stage operating experience at an AI company. Experience inside a company that scaled fast. Why join us? Competitive salary and equity Full healthcare coverage; we pay 100% of premiums for you and your dependents Support for growing families, including a yearly new parent stipend and fertility coverage through Carrot Mental health support through Rula, our in‑network therapist and psychiatrist network with fast availability 12 weeks of paid parental leave for maternity, paternity, and adoption Pet care support with a yearly employer‑funded stipend for your animal companions Commuter benefits so you can pay for transit and parking with pre‑tax dollars 401(k) company matching $300 health and wellness benefit quarterly Lunch is on us every day you're in the office, and dinner is on us when you're working late Regular team offsites and company events A fast‑moving, mission‑driven culture where smart people do their best work and actually enjoy doing it Edison Scientific is an equal opportunity employer. We do not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, veteran status, or any other protected characteristic under applicable law. Compensation Range: $180K - $220K #J-18808-Ljbffr
- ...in a defining moment — from turnaround to international growth, from traditional rideshare to the autonomous future. The Chief of Staff to the CEO sits at the center of that transformation, serving as a force multiplier for CEO David Risher and the senior leadership team...SuggestedHourly payWork at officeLocal area
$150k - $200k
...and accountable government and the vision of high-performance government for every community at OpenGov.com.Role OverviewAs Chief of Staff to the CEO, you will sit at the center of how this company operates and makes decisions. You will own the operating cadence, drive...SuggestedContract workWork at officeLocal area$401 per month
...Chief Of Staff To Co-Founder And CeoThis is Chief of Staff to Sam Rodriques, Edison Scientific's co-founder and CEO. This role is one of the highest-leverage seats in the company: you will sit next to Sam, with a front-row view of how Edison is built and how we are accelerating...SuggestedFull timeWork at office- ...for thoughtful, driven people excited to work at the intersection of AI, Security, and Infrastructure. About This Role As Chief of Staff to the CEO, you'll operate at the center of the company working directly with the CEO and executive team as the company scales through...SuggestedWork at office
$150k - $200k
...office. Candidates must be able to reliably commute to the office Monday–Friday.What You'll Do:Serve as a trusted thought partner to the CEO, working side-by-side on strategic priorities, planning cycles, and special projects that drive Inkitt's growth.Oversee cross-...SuggestedWork at officeMonday to Friday- ...that someone else sold back. So that's what we make: a liquid market for GPU offtake. About The Role SF Compute is seeking a Chief of Staff to the CEO to serve as a strategic partner and force multiplier to the CEO. This role combines strategy, operations, and execution,...Long term contractContract workFixed term contractWork at officeLocal areaVisa sponsorshipShift work
- ...Chief of Staff to the Chief Executive Officer (CEO) About the Company Innovative provider of cloud-based financial services for local & national governments Industry Computer Software Type Privately Held, VC-backed Founded 2012...Contract workLocal area
- ...The RoleThe Chief of Staff to the CEO is Garrett Lord's closest execution partner — the person who helps him get things done at extraordinary speed across Handshake's mutually reinforcing business lines: our network, recruiting platform, and AI data work. You'll turn his...Full timeWork at officeRemote workFlexible hours
- ...Chief of Staff to the CEOSan Francisco, CaliforniaRZR is an AI-native advertising platform built for the next era of performance marketing... ...shape what it becomes.Role OverviewThe Chief of Staff to the CEO is a strategic operator role, not an administrative one. You will...
- ...Capital, looking for builders who want to solve hard problems.The Role & CultureWe are seeking a sharp, organized Chief of Staff to support HomeVision's CEO and company operations. This role is focused on acting as a strategic operational partner to the CEO,...Flexible hours
- ...ambitious, high-energy team, we’d love for you to join us. About The Role Chief of Staff at Heliux will be directly responsible for leading business operations and closely partnering with the CEO to run strategic projects that solve the company’s most pertinent problems...Permanent employment
- ...Chief Of Staff Opportunity At Hike MedicalHike Medical is building the defining company in musculoskeletal care. We sit at the intersection... ....The OpportunityWe're hiring a Chief of Staff to serve as the CEO's force multiplier and operational backbone of the company.This...Work at office
$200k - $250k
...and MIT. Learn more at About the Team The Office of the CEO operates at the center of Turing's highest-priority strategic... ...decisions are made. The Role This is not a traditional Chief of Staff role. Rather than running internal operations, you will become...Full timeWork at officeImmediate startMonday to FridayWeekend work- DepthFirst AI, Inc. is seeking a Chief of Staff to the CEO to operate at the center of the company, translating strategy into execution and steering cross‑functional initiatives as the organization scales. In this high‑visibility role, you’ll prepare board materials, run...
- Institution: AI Fintech Startup - SaaS for Financial Services Role: Chief of Staff to the Founder & CEO About the Company Our client is a Seed Stage AI FinTech start-up that is building training environments for AI agents and models for financial services verticals, but...Full timeRelocation
$256k - $320k
...Notion, Coinbase, and Palantir, among others Build a massive, fast‑growing business with billions in revenue The Role The Chief of Staff to the CEO is one of the highest‑leverage roles at Handshake — a seat at the center of our most consequential decisions as we enter...Full timeFreelanceInternshipWork at officeRemote workFlexible hours- BackOps AI is seeking a Chief of Staff in San Francisco to support the CEO and build the systems essential for company operations. This high-ownership role involves managing operational details, strategic financial modeling, and contributing to board materials. The ideal...
- San Francisco Compute in San Francisco seeks a Chief of Staff to act as a strategic partner to the CEO, blending strategy, operations and execution to accelerate the company's most important priorities. You will coordinate across engineering, product, and GTM, translate...Work at office
- VSCO is seeking a Chief of Staff to work directly with the CEO in San Francisco, driving execution across the company and owning high‑stakes projects. You’ll build operating rhythms, prioritize decisions, and ensure initiatives move from plan to action while partnering...
- ...high-caliber team turning the art of sales into a scalable science. About the Role We’re looking for a Chief of Staff who will operate as a true extension of the CEO. This is a rare opportunity to work directly alongside the CEO and gain an inside view into how a high-...
- ...ambition and our internal operating foundation is widening, and closing it is now a priority. We are looking for a Chief of Staff to work directly with our CEO: to build the systems the company runs on, own the operational details that cannot slip, and grow into a...Work at officeShift work
- depthfirst is seeking a Chief of Staff to the CEO in San Francisco. You will operate at the center of the company, turning strategy into execution, running cross-functional initiatives, and handling high-stakes decisions with clarity and speed. You will drive company-wide...
- Formic, a company redefining American manufacturing, is hiring a Chief of Staff to support the CEO in driving high-impact strategies and initiatives. This role requires strong judgment, ownership, and operational efficiency. Responsibilities include maintaining CEO focus...
- American Terawatt in San Francisco is seeking a chief of staff to the CEO. This is not an administrative role; you will stand up new functions, assess feasibility of strategic projects, and act as a trusted proxy with delegated decision making. You will coordinate across...
- Lyft is in a defining moment — from turnaround to international growth, from rideshare to the autonomous future. The Chief of Staff to the CEO sits at the center of that transformation, serving as a trusted partner to CEO David Risher and the senior leadership team. This...Work at office
$150k - $235k
...What You Will DoYou will work extremely closely with, and act as a force multiplier to the CEO: taking on our hardest, most complex, most interdisciplinary problems… to make sure the company runs well and WINS!You Should Expect The Role To Progress As FollowsFirst day:...Full timeWork at officeRelocation packageWeekend work- Heliux is building an AI-native operating system for the manufacturing enterprise. The Chief of Staff will lead business operations, partnering with the CEO to drive strategic projects across finance, recruiting, HR, compliance, and investor relations. The role requires...
- gigaml in San Francisco is looking for a Chief of Staff to support the CEO in driving strategic initiatives and operational efficiencies. This role involves managing board preparations, facilitating internal and external communications, and enhancing the overall effectiveness...Full timeWork at office
- ...AI, a U.S.-based cloud AI infrastructure company, is seeking a sharp, highly organized executive operations professional to join the CEO and founding team. You will help prioritize initiatives, track progress, and streamline decisions as the company scales rapidly. You...
$135k - $175k
A leading AI software company in San Francisco is looking for a Chief of Staff to support the CEO and streamline operations. This role involves coordinating meetings, drafting communications, and preparing fundraising materials. Candidates should have 6-10 years of relevant...Flexible hours
Do you want to receive more vacancies?
Subscribe and receive similar vacancies to Chief of Staff, CEO. Be the first to apply!
- chief of staff to the ceo San Francisco, CA
- chief of staff remote San Francisco, CA
- chief of staff San Francisco, CA
- executive assistant to chief executive officer San Francisco, CA
- assistant to the executive director San Francisco, CA
- financial executive San Francisco, CA
- executive search company San Francisco, CA
- managing director of operations San Francisco, CA
- senior manager executive compensation San Francisco, CA
- executive director senior living San Francisco, CA


