Senior Director, Clinical Practice Liaison Team- East Region

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH) a serious liver disease that can progress to cirrhosis liver failure need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigals medication Rezdiffra (resmetirom) is a once-daily oral liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic inclusive and high-performing culture that values scientific excellence operational rigor and collaboration. To support our continued growth we are strengthening our workforce strategy to ensure we have the right talent at the right time in the right way.

Role Summary:

The Senior Director Clinical Practice Liaison (CPL) is a senior leadership role with broader strategic accountability for the CPL function (part of the Field Medical Team at Madrigal) within a defined U.S. region and therapeutic area. This individual will play a pivotal role in shaping the vision direction and performance of the CPL team ensuring the team aligns with and advances the companys overarching medical strategy adheres to regulatory and internal policies and maximizes scientific impact for both internal and external stakeholders.

This position will collaborate closely and compliantly with cross-functional colleagues (e.g. Marketing Sales Market Access Clinical Operations HQ Medical Affairs) and external partners including healthcare decision-makers and other relevant stakeholders serving as a key liaison to drive strategic initiatives and influence medical and business outcomes.

The position reports to the Executive Director Field Medical and is a field-based position with travel required within assigned territory.

All incumbents are responsible for following applicable Medical Affairs & Madrigal policies and procedures and are compliant with applicable policies procedures and regulations. Strong understanding of US regulations and compliance is required.

Please note: Candidates may reside anywhere within the Eastern United States.

Key Responsibilities and Primary Activities:

• CPL Team Scientific & Clinical Education

• • Support and help shape the regional strategy for the CPL team to deliver unbiased evidence-based education on MASH ensuring CPLs address identified gaps in knowledge and clinical implementation

• • Promote consistent and high-quality communication of clinical practice guidelines and real-world data related to MASH diagnosis risk stratification and patient management

• • Maintain strong working knowledge of MASH Non-Invasive Testing (NITs) treatment paradigms and clinical protocols across the liver/metabolic spectrum while providing scientific guidance to the team

• CPL Team Practice Engagement & Enablement

• • Support the Executive Director in the oversight of practice engagement ensuring CPLs effectively support implementation of MASH care pathways

• • Support adoption of guideline-based approaches payer-aligned workflows and quality-driven practice standards across the region.

• • Ensure accuracy and compliance in CPL responses to unsolicited inquiries reinforcing regulatory expectations

• Team Leadership & Development

• • Recruit coach and manage performance of regional CPLs

• • Foster continuous development through mentoring structured training and scientific upskilling

• • Ensure CPL activities align with strategic objectives and tactical plans supporting consistency and quality in execution

• Medical Strategy Execution

• • Execute regional field medical strategies in alignment with national direction

• • Translate national medical objectives into actionable regionally tailored field activities

• • Partner with HQ Medical Affairs and cross-functional leaders to integrate meaningful field insights into medical planning

• Clinical Trial Support

• • Collaborate with Clinical Operations to support successful study execution based on regional site and practice needs

• • Identify potential research sites or practice barriers informed by field insights

• Cross-Functional Collaboration

• • Act as a regional medical point-of-contact partnering across Medical Affairs Sales Marketing Market Access and Clinical Operations to maintain alignment and address clinical or strategic needs

• • Serve as a conduit for HQ Medical Affairs initiatives ensuring clear communication and coordinated execution

• • Contribute to launch readiness and lifecycle management activities ensuring CPL efforts support national and regional priorities

• • Represent Madrigal at scientific meetings supporting CPL engagement and ensuring compliant scientific exchange and insight collection

• Insight Gathering & Strategic Feedback

• • Synthesize prioritize and elevate regionally derived insights to inform medical strategy evidence-generation planning and educational needs

• • Keep abreast of regional analysis of emerging clinical trends and barriers to care providing strategic recommendations for internal planning

• • Ensure structured compliant insight reporting across the CPL team

• Compliance & Professional Standards

• • Adhere strictly to all applicable company and regulatory policies including FDA and industry guidelines for non-promotional medical engagements

• • Ensure thorough documentation and accountability for all scientific interactions.

• • Maintain a strong understanding of US regulations and compliance

• Travel Requirement

• • Ability to travel from 25-70% including support of scientific meetings over weekends

Required Qualifications Skills & Experience:

• Advanced degree in a scientific or healthcare discipline (MD PharmD PhD DNP etc.)

• Minimum 5 years of Medical Affairs experience including at least 3 years as an MSL or equivalent (translatable clinical practice experience will be considered)

• Minimum 3 years of people management experience or formal leadership development participation

• In-depth knowledge of clinical medicine and medical research

• Proven ability to understand communicate and translate complex scientific information

• Strong knowledge of U.S. healthcare system FDA regulations and medical affairs compliance standards

• Demonstrated cross-functional collaboration project execution and strategic planning skills

• Proficiency in Microsoft Office Suite virtual communication platforms (e.g. Zoom Teams) and related Medical Affairs Systems (e.g. Veeva Vault CRM tools)

Preferred Attributes:

• In-depth knowledge of liver disease; experience in cardiometabolic health or endocrinology/metabolic disease

• Strong interpersonal presentation and relationship-building skills

• Adaptable and proactive in a fast-paced evolving environment

• Passion for mentoring team building and field-based medical innovation

#LI-Remote

Madrigals Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance we empower employees to think like owners giving them a stake in the organization.

All employees receive equity which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidates qualifications skills education experience business needs and market demands. The base salary range for this position is $264000 - $322000 per year.

All full-time employees receive equity which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance we empower employees to think like owners giving them a stake in the organization.

Full-time employees are also eligible for comprehensive benefits including flexible paid time off medical dental vision and life/disability insurance and 401(k) offerings (i.e. traditional Roth and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance legal services and other addition we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal state and local laws.

We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance please contact

Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications merit and business need. Applicants will receive consideration for employment without regard to race ethnicity color religion sex gender identity sexual orientation national origin age disability protected veteran or disabled status or other characteristic protected by applicable federal state or local law.

Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established.

Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site.

Please be aware that we have received reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals Hiring Managers seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigals name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g. fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process.

Please also note that any correspondence with regard to employment would come from an authorized email address or from an email address from one of our trusted search firm partners. We are aware that incorrect/fraudulent email addresses with Madrigal misspelled have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for or on behalf of Madrigal we recommend that you: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks. Any questions regarding the legitimacy of job-related contacts can be directed to .

Required Experience:

Exec