Principal Research Associate, Antibody Discovery (Immunology)

Job Description

Job Description

Title: Principal Research Associate, Antibody Discovery (Immunology)

Adimab is the leading technology provider for therapeutic antibody drug discovery, focusing solely on our partnerships without pursuing an internal product pipeline. Since 2009, we have partnered with over 140 pharmaceutical and biotechnology companies, generating more than 650 therapeutic programs, of which more than 85 have entered clinical trials.  

Role Overview:
We are seeking an experienced, self-motivated, and enthusiastic biologist/bioengineer to join our Antibody Discovery immunology team. The Principal Research Associate will work in a small, collaborative team to execute and advance Adimab’s  in vivo antibody discovery and optimization platform against challenging targets.  This role will closely interface with a variety of internal Adimab teams and work closely with external drug discovery partners. The successful candidate will have prior experience in immunology, biotechnology, and flow cytometry.

Responsibilities: 

• Basic handling and culture of yeast and mammalian cells
• Murine and human lymphocyte sample handling and characterization
• Primary B cell isolation using fluorescence activated cell sorting (FACS)
• Collecting, organizing, analyzing, data for a variety of internal and external presentations
• Interpreting antibody characterization data
• Construction and selection of yeast antibody libraries
• Mammalian cell-based characterization assays
• Quantification of antibody and B cell responses
• Single-cell RT-PCR
• Tracking and upkeep of lab reagents and stocks
• Collaborating effectively with internal departments and external partners

Needed Upon Hire:

• B.S. or M.S. in immunology, molecular biology, biological engineering, cellular biology, or a closely related field with 4+ year(s) experience in an academic or industry setting
• Demonstrated experience with basic laboratory techniques (e.g. PCR, stoichiometric calculations, molecular cloning, sterile sample handling, sterile tissue culture, flow cytometry)
• Demonstrated ability to evaluate, interpret, and present scientific data with a mastery of Microsoft Excel and Powerpoint
• Familiarity with the basic concepts of immunology and antibody responses
• Excellent organization skills, problem-solving skills, and attention to detail
• Self-directed with a proven track record of executing independently at the bench and driving projects to completion
• Adaptable and productive in a fast-paced environment
• Effective communication skills with the ability to speak openly with colleagues and supervisors
• Demonstrated success working within a team and collaborating with multiple groups in an organization

Value-added Experience:

• Significant previous experience with standard immunological assays (e.g. ELISA, flow cytometry), single-cell RT-PCR, and  immune or synthetic library building and selection,  would distinguish a highly qualified candidate
• Significant yeast handling and antibody engineering background
• Experience with the design and execution of mammalian immunization strategies

Come join us!
Our integrated antibody discovery and engineering platform provides unprecedented speed from antigen to purified, full-length human IgGs with exquisite specificity and biophysical behavior. We offer fundamental advantages by delivering diverse panels of antibodies that meet the most demanding standards for affinity, epitope specificity, species cross-reactivity, and developability. We enable our partners to rapidly expand their biologics pipelines through a broad spectrum of technology access arrangements.

As a profitable privately-held biotech company, we take a long-term view on value creation and make substantial investments in technology development, research, and our people. We offer individually tailored compensation packages comprised of a competitive salary, meaningful equity, a 2:1 401(k) match, and comprehensive health care benefits.

Located in New Hampshire’s beautiful Upper Connecticut River Valley, we are minutes from Dartmouth College, the Geisel School of Medicine, the Thayer School of Engineering, the Tuck School of Business, and the Dartmouth Hitchcock Medical Center. We are fortunate to be situated in an area that is renowned for its premier skiing, hiking, kayaking, and biking.

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