Principal Analytical Scientist (Automation)

Principal Analytical Scientist

At Regeneron, we use science and innovation to develop life-changing medicines for people with serious diseases. We are seeking a Principal Analytical Scientist to join our Quality Control team in Rensselaer, NY, supporting our IOPS organization on-site. In this role, you will shape the future of QC analytical testing by designing, developing, and scaling automated assay workflows across advanced laboratory platforms, while mentoring scientists and fostering a culture of technical growth and innovation. This position offers the opportunity to contribute to a fast-growing, science-driven organization making a meaningful difference to patients worldwide.

Location: Rensselaer, NY (Tempel Lane)

Work Shift: Monday-Friday 1st shift

Discover your role:

• Lead the design, implementation, and optimization of automated assay workflows across modern laboratory platforms, applying deep expertise in mass spectrometry, chromatography, bioassay, electrophoresis, and ELISA.
• Mentor and develop junior and mid-level scientists, building team capability in analytical science and laboratory automation.
• Set priorities, coordinate work, and track progress on analytical and automation initiatives against key milestones.
• Independently design and execute studies to evaluate emerging automation technologies and troubleshoot existing systems with limited supervision.
• Lead complex investigations into automated method performance, supporting verification activities and driving continuous improvement.
• Transfer automated workflows to QC and partner functions by developing training materials, transfer plans, and acceptance criteria.
• Engage cross-functional collaborators and equipment vendors to evaluate new technologies and assess their fit for QC applications.
• Prepare clear scientific reports, automation procedures, and SOPs; communicate findings, risks, and mitigation strategies to management and cross-functional teams.
• Bring hands-on experience programming and optimizing automated liquid handling systems (e.g., Hamilton/Venus, Andrew+/OneLab, or Cellario) and scripting in Python, R, or VBA.
• Apply strong troubleshooting skills across both analytical methods and automated instrumentation to resolve complex technical challenges.
• Make sound, independent decisions and proactively recommend experiments or solutions based on deep expertise in analytical science and automation.

This role requires:

• 8+ years of industry experience in analytical development, laboratory automation, and QC method lifecycle management (or equivalent combination of education and experience).
• Demonstrated hands-on expertise in automated liquid handling platforms and associated software programming.
• Proficiency in scripting languages (Python, R, or VBA) for data analysis, workflow automation, or system integration.
• Deep knowledge of QC analytical techniques including mass spectrometry, chromatography, electrophoresis, bioassay, or ELISA.
• Proven ability to work independently, design scientifically sound studies from broad objectives, and drive projects to completion.
• Level will be determined based on qualifications at the time of offer.

Preferred:

• PhD in Chemistry, Biochemistry, Biology, or a related field.
• Previous experience working in a cGMP or cGLP regulated environment.
• Familiarity with Cellario, Venus (Hamilton), or OneLab (Andrew+) automation platforms.
• Experience developing and executing technology transfer plans across QC or partner functions.

Physical Requirements: Ability to work in a laboratory environment, including standing for extended periods and handling laboratory equipment.

Gowning & Environment: This role operates in a GMP analytical laboratory. Appropriate gowning and PPE are required in designated areas.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.

The final offer will be determined within the relevant range based on the country of employment, specific role level, and your skills and experience.