Pharmacology Research Scientist, Ex Vivo

Job Description General Summary: The CGT Pharmacology group in Boston is seeking a highly motivated and innovative Pharmacology Research Scientist to work collaboratively across the Research organization by supporting pharmacology efforts to understand the pharmacokinetics, pharmacodynamics, and efficacy of novel cell and gene therapies in disease models. The successful candidate will focus on developing, optimizing and validating PK/PD assays, immunoassays, custom multiplexes, and primary cell/explant assays supporting both early discovery and IND-enabling phases. This role requires a specialized technical expert in assay development (e.g. immunoassays, cell assays, flow assays, etc.) who can lead work streams, prioritize data integrity/documentation and mentor others within the team. Strong technical and problem-solving skills, self-motivation, presentation/communication skills, and the ability to both leads, as well as thrive as part of a team are essential. Key Duties and Responsibilities: Designs, optimizes and executes preclinical PK, and immunoassay and cell assays to support pharmacology research efforts Uses a high level of scientific judgment and creative thinking to adapt and/or create standardized workflows & protocols by applying breadth of knowledge and prior work experience. Takes ownership of daily tasks, researching answers and contacting other subject matter experts independently before soliciting support from senior team members. Exercises emerging judgment to prioritize workload, based on project impact. Communicate and work collaboratively within and across functions to support programs from early discovery through preclinical proof of concept and candidate selection to advance the company pipeline. Authors and reviews Bioanalytical reports for regulatory filings Analyze, interpret, and present experimental data to project teams and senior leadership. Possesses a strong understanding of the drug development process and showcases enterprise thinking. Knowledge and Skills: Proven technical proficiency and demonstrated skill in planning and interpreting experiments, including the measurement of the action of cell/gene therapies on in vitro or in vivo disease biology assays (PK/PD, Ligand Binding assays, primary cell/tissue culture, immune cell assays, custom multiplex, flow cytometry). Strong analytical and organizations skills with the ability to operate automated assay systems and analyze/collect data to interpret complex data sets (Hamilton, Integra, etc.) Proficiency in data analysis software and tools (GraphPad Prism, Spotfire, FlowJo, VENUS lab automation software, etc.). Assesses situations using existing knowledge and best practices, proactively asking for assistance when defined boundaries or technical limitations are reached. Demonstrates understanding of analysis and interpretation of relatively complex experimental data with proficiency in problem solving and protocol/procedure refinement. Effective communicator (written and verbal) and presenter, with the ability to work effectively in a collaborative team environment. Often deployed to investigations with more significant consequences and need for reliability Education and Experience: Bachelor’s degree and 10 years of industry experience or, Master’s degree and 5 years of industry experience or, PhD and 3 years of industry experience Pay Range: $110,900 - $166,300 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: On-Site Designated Flex Eligibility Status: In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Onsite Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at View email address on click.appcast.io Help Us Achieve Our Mission Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has approved medicines that treat the underlying causes of multiple chronic, life-shortening genetic diseases — cystic fibrosis, sickle cell disease and transfusion-dependent beta thalassemia — and continues to advance clinical and research programs in these diseases. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including APOL1-mediated kidney disease, acute and neuropathic pain, type 1 diabetes, myotonic dystrophy type 1 and alpha-1 antitrypsin deficiency . Founded in 1989 in Cambridge, Mass., Vertex's global headquarters is now located in Boston's Innovation District and its international headquarters is in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 14 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit or follow us on Facebook, Twitter/X , LinkedIn, YouTube and Instagram. The diversity and authenticity of our people is part of what makes Vertex unique, and we recognize that each employee brings diverse perspectives and strengths. By embracing those strengths and celebrating differences, we are fostering an inclusive culture where each of us can bring our authentic selves to work, inspire innovation together, and change people’s lives. Our vision is clear: to be the place where an authentic, diverse mix of talent want to come, to stay, and do their best work.