Scientist I, Drug Product

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.The Opportunity:The successful candidate will contribute to formulation and process development activities from early-stage through late-stage clinical/commercial development, working closely with cross-functional partners and CDMOs to ensure robust, scalable, and compliant drug product manufacturing processes.Key Responsibilities:Contribute to drug product development activities for new chemical entities (NCEs) from early development through late-stage clinical development, with exposure to commercialization activities.Design and execute drug product development and manufacturing activities for solid oral dosage forms, including:Preformulation and formulation developmentManufacturing process developmentProcess scale-up, technology transfer, and process optimizationProcess validation and commercial manufacturing supportSupport outsourced development and GMP drug product manufacturing activities at CDMOs including manufacturing oversight and troubleshooting.Design and execute experiments, analyze and interpret data and present results and conclusions to project teams.Work independently with limited supervision to conduct appropriate research and troubleshoot technical challenges, escalating complex issues as needed.Author and contribute to CMC documentation for regulatory submissions (e.g., INDs, NDAs, MAAs) and internal technical reports.Collaborate cross-functionally within CMC team (Clinical Supply, Analytical Development/QC, Quality Assurance, Drug Substance, Regulatory Affairs, and Project Management) and at enterprise level research/clinical/commercial teams to support aligned development strategy and execution.Travel up to 20% to CRO/CDMO sites to support and oversee development and manufacturing operations.Required Skills, Experience and Education:A degree in Pharmaceutical Science, Chemistry, Chemical Engineering, or closely related field is desirable.D. with 0-2 years of experience or a bachelor’s/master’s degree with appropriate experience in the pharmaceutical/biotech industry settings.Academic or research experience relevant to drug product development, formulation, pharmaceutical sciences, or small molecule development is preferred.Knowledge of solid oral dosage forms, formulation principles, and pharmaceutical manufacturing processes gained through graduate research, coursework, internships, or related training is desirable.Familiarity with formulation and process development concepts for small molecule drug products is preferred.Basic understanding of pharmaceutical development, CMC principles, and global regulatory guidelines, including ICH guidelines, is desirable.Exposure to working in multidisciplinary or collaborative research environments, including interactions with internal or external scientific partners, is a plus.Strong scientific, technical writing, communication, and problem-solving skills.Demonstrated ability to analyze experimental data, draw scientifically sound conclusions, and communicate results effectively.Ability to learn quickly, manage multiple priorities, and work effectively in a fast-paced, innovation-driven, collaborative environment.Preferred Skills:Ph.D. degree in Pharmaceutical Science, Chemistry, Chemical Engineering, or closely related field is desirable.The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact View email address on click.appcast.io Pay Salary Range$119,000—$149,000 USDWe are aware of recent recruitment scams in which individuals or organizations falsely represent themselves as being affiliated with Revolution Medicines. These scams may appear as false job advertisements or unsolicited contacts through communication or chat platforms, email, phone, or text message.Please note that Revolution Medicines does not extend unsolicited employment offers and will never ask candidates to provide financial information, purchase equipment, or pay fees as part of the hiring process. All legitimate communication from Revolution Medicines will come from an official @revmed.com email address.If you believe you’ve been contacted by someone impersonating a Revolution Medicines recruiter, please report it to View email address on click.appcast.io so we can share these impersonations with our IT team for tracking and awareness.