Senior Principal Information Security Analyst, Defensive Operations
$153.5k - $250.5kRegeneron Pharmaceuticals
Build our future together
We’re looking for a hands-on leader to own the platforms that give our security teams visibility across the enterprise. You’ll lead a team supporting the Security Monitoring function. The team builds and maintains the Splunk log ingestion pipeline, RBAC, searches, reporting, and dashboards. It also supports the systems that feed our Security Information and Event Management (SIEM) platform, which correlates it all.
This is a player-coach role, roughly 50/50 technical work and team leadership. You’ll lead a mixed team of employees and vendor staff and act as the escalation point when monitoring platforms or security incidents need senior attention. You’ll also explain complex technical topics clearly to non-technical stakeholders.
At Regeneron, our SIEM has grown tremendously, and we support business functions beyond security, including Finance, IT, Manufacturing, and Research. We cautiously push the boundaries of the product, evaluating cutting-edge technology in our test environment and deploying capabilities that reshape how Regeneron and other users think about a SIEM.
Where and When
Location: 100% remote (US East Coast time zone).
Team: 4-10 employees and vendor resources.
Discover your role
Platform health and operations
- Own the availability, performance, and data quality of the SIEM and log collection infrastructure.
- Drive the team and platform toward zero skipped searches, zero unplanned downtime, and no logging errors that affect monitoring.
- Forecast data growth and manage ingest and compute within licensed capacity.
- Provide metrics, performance reports, and dashboards to leadership.
- Apply ITIL practices to incident, request, and change management.
Vendor and service management
- Manage vendor relationships and contracts, including SLA definition, performance reviews, and service review meetings.
- Direct a mixed team of employees and external resources, assigning work in line with shared strategy and goals.
- Lead responses to audit requests related to monitoring systems and controls.
Incident escalation and response
- Escalate incidents and enhancement requests to internal owners and vendors as needed.
- Coordinate with stakeholders during cybersecurity incidents.
- Support triage and escalation of security events and threats, using SIEM data to assist investigations.
Improvement and engineering partnership
- Partner with engineering and architecture teams to define requirements and set feasible timelines.
- Deliver projects that improve security event collection, detection, analysis, correlation, and response.
- Advise infrastructure and security teams on configuration changes that improve event collection.
- Track emerging trends in AI, machine learning, and analytics for security monitoring, and recommend where they add value.
Team management
- Align the team with common short- and long-term goals.
- Make sure the team has the tools it needs, and remove blockers.
- Give team members frequent performance feedback, so they know they’re valued and where they can improve.
- Build a trusting environment where it’s safe to ask for support and to suggest better ways of working. 1 Team; 1 Platform.
This role requires:
- 10+ years in IT, including 5+ years in security operations or as a monitoring system manager or lead engineer.
- 5+ years leading or directing technical teams, including contractor staff.
- Expert-level Splunk experience; Splunk Certified Consultant or equivalent demonstrated expertise.
- Advanced Red Hat Linux skills.
- Advanced scripting in Python and Bash.
- Advanced rsyslog configuration experience.
- Experience writing technical requirements and working with engineering teams to deliver them.
- Strong written and verbal communication, with the ability to build relationships and present to audiences from engineers to executives.
- Sound judgment in weighing security controls against technical and administrative standards and making risk-appropriate tradeoffs.
Preferred Qualifications
- Experience with Splunk Enterprise Security and SOC operations, including triaging security incidents and threats.
- Experience overseeing managed service delivery and vendor SLAs.
- Experience with security telemetry sources such as syslog, Universal Forwarder and heavy forwarder deployments, Splunk DB Connect, and the VMware Data Collection Node.
- Familiarity with modern detection technologies (EDR/XDR) and cloud security logging.
- Experience in a large, complex organization working across multiple business lines.
Why Join Us
- We share a common goal: to build the best Security Monitoring platform and SIEM, and to be trusted advisors to our partners on the Security team and across the business. We work regularly with Splunk product management to shape cutting-edge tools such as Ingest Processor, UEBA, Dashboard Studio, and SOAR, helping the platform become what Regeneron and the industry need.
- 1 Team; 1 Platform; 1 Common Goal. Our sub-goals are ambitious, and we’re still working toward them: no skipped searches, no downtime, and no errors that affect logging or monitoring.
- Our team members are regularly invited to speak at industry conferences.
- Health, Family, Work (in that order).
Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We are committed to building a workplace with an inclusive culture. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.
Where necessary, we disclose salary ranges for roles in all countries in which we operate. The final offer will be determined within the relevant range based on the country of employment, specific role level, and your skills and experience. In some countries, collective bargaining agreements (CBAs) may apply and influence certain elements of pay or benefits. Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits. For additional information about Regeneron benefits in the U.S., please visit . For other locations, additional information will be provided during the recruitment process. If you have any questions, please speak with your recruiter.
Please be advised that at Regeneron, we believe we do our best work when we are together. For that reason, many roles are required to be performed on‑site. Please speak with your recruiter and hiring manager for more information about on‑site expectations for your role and location.
As part of the recruitment process, certain background checks may be conducted in accordance with the laws of the country where the position is based. The purpose of such checks is to verify certain information prior to the commencement of employment such as identity, right to work and educational qualifications.
For jobs in Canada: this posting is for an existing position.
Salary Range (annually)
$153,500.00 - $250,500.00$134.35k - $194.75k
Job-ID: 393751Category: Information SecurityLocation:... ...support Cyberdefense Operations.Union Job: NoArea of Interest... ...overtime payThe Principal Information Security Analyst serves as a senior leader within the Cybersecurity... ...into Cyber Defense and enterprise decision...OperationsPrincipalLocal areaRemote workFlexible hours$94.49k - $131.16k
...we can achieve. Together.SummaryThe Senior Information Security Analyst is responsible for identifying,... ...managing relationships with our security operations vendors and providing technical... ...attackers, which supports proactive defense measures. Intrusion Detection: Solid...OperationsSeniorFull timeWork at officeRemote workRelocationRelocation package$145k - $200k
Washington, D.C.Information Security /Full-time /On-siteA World-Changing CompanyPalantir builds... ...for data-driven decisions and operations. By bringing the right data to the... ...missing children, and more.The RoleAs a Defensive Security Analyst, you are responsible for the...OperationsFull timeWork experience placementWork at officeRemote workWork from homeRelocation package- Job Title: Information Security Analyst Senior LeadWork Place Flexibility: Hybrid Legal Entity: Entergy Services... ...the Entergy Consolidated Security Operations Center (CSOC) which is responsible... ..., identify gaps to improve defensive controls, expand offensive security...OperationsSeniorWork at officeLocal areaRelocationVisa sponsorshipWork visa
- ...outcomes and accelerate time-to-therapy. Job Title: Senior Information Security Analyst POSITION SUMMARY: Under the general supervision... ...in incident response alongside our managed security operations provider, coordinates the annual external penetration test...OperationsSeniorFull timeRemote workFlexible hours
- ...The MSRB seeks an Information Security Analyst to help protect our systems, support daily security operations, and strengthen our security controls. Reporting to the Director,... ...emerging threats and help strengthen the MSRB’s defenses. Qualifications All candidates...OperationsRemote work
- ...Senior Information Security Risk Analyst Rootshell Enterprise Technologies Inc. is a recognized provider of professional IT Consulting services in... ...Strong understanding of IT infrastructure, enterprise operations, and risk impact assessment methodologies ~ Experience...OperationsSeniorRemote work
- ...applications and next steps. Our partner is looking for a Senior Information Security & Compliance Analyst based in the United States. As a Senior... ...establish scalable security practices that protect business operations, technology infrastructure, and customer data....OperationsSeniorFull timeRemote workFlexible hours
- ...About the role The team at Laivly is looking for a Senior Information Security & Compliance Analyst to help strengthen and evolve our information... ...customers, and business. You'll work closely with IT Operations, Architecture, Engineering, and cross-functional teams...OperationsSeniorFull timeRemote workFlexible hours
- ...trusted source of reliable education and information that allows people to make informed... ...Planned Parenthood affiliates operating health centers across the U.S.... ...PPAF) seek a dynamic and effective Senior Information Security Analyst . This job reports to the Director...OperationsSeniorWork experience placementWork at officeImmediate start
- Information Security Data Protection Analyst (Contract) Corporate Services - Information Technology... ...aligns with the Cyber Defense Analyst work role within... ...CASB). Escalate alerts to Senior Analyst, Lead, or Team... ...testing, implementation, and operation, project requirements...OperationsFull timeContract workWork experience placementWork at officeRemote workMonday to Friday
$28 - $32 per hour
...Department 00954 - UIT Systems & Security Location Location Campus City... ...for a Cybersecurity Analyst Tier 1 (Security Operations Center) to help support our Information Security and Compliance goals... ...will serve as the first line of defense against cyber threats, responsible...OperationsWork experience placementWork at officeShift workNight shiftDay shiftAfternoon shift- ...Prevailance is seeking a highly skilled Senior Information Security Analyst to support the planning, design, implementation, operation, and reporting of cybersecurity systems across... ...: Senior-level cybersecurity and defensive cyber operations experience Skilled in...OperationsSeniorContract workRemote work
$54k
Job Opening: Associate Information Security Analyst Department: Information Security Functional Team: Security... ..., findings, and action. The analyst operates the company's security platforms,... ...techniques, least privilege, and defense in depth. Exposure to endpoint protection...OperationsFull timeWork at officeRemote workShift work$72.95k - $90k
Senior Information Security Compliance Analyst (Hybrid) Anticipated Salary Range: $72,946-$90,000 The State Corporation Commission (SCC) seeks a Senior... ...compliance tools and technologies to ensure their effective operation and continuous improvement Ensure security practices...OperationsSeniorWork at officeRemote work2 days per week$87k - $92k
...RoleWe are seeking an experienced Information Security Analyst to support security operations, incident response,... ...on technical role operating as a senior practitioner within a Security Operations... ...technologies, attack techniques, and defensive practices.Why is This a Great...OperationsRemote workVisa sponsorshipFree visa$80k - $120k
...026-09-29 Category: Information Technology Subcategory: IT Security Administrator Schedule... ...and Authorization analyst for the Cloud team to... ...services to facilitate the operations and modernization of the... ...for Network. support/defense (e.g., Splunk, Cisco, McAfee...OperationsFull timeContract workInterim roleRemote workMonday to FridayShift workWeekend work- ..., Texas / Chandler, ArizonaGlobal Operations - IT /Full Time /HybridFor over four... ...career! We are seeking a seasoned security professional to join our Information Security team and help strengthen... ...posture for stakeholders and senior leadership.Required Skills and Qualifications...OperationsSeniorFull timeWork at officeRemote workWork visa2 days per week
$67.2k - $80k
...span the mortgage continuum and enhance security, compliance, customer satisfaction, and... ...Do Responsible for supporting the Information Security awareness program initiatives,... .... Resolves security problems to obtain operations across all platforms including email, files...OperationsFull timeWork experience placementLocal areaRemote work$116.5k - $163.84k
...Chimes | Information Security Analyst | Remote Position We're looking for an Information Security Analyst to protect information systems, data, and operations for Chimes. Location: This role is remote within the USA. You must be legally authorized to work in...OperationsHourly payFull timeRemote work- ...Senior Information Security Analyst Status: Exempt Reports to: Manager - Information Security Investigations Department: IT - Info Sec Analysis... ...administration, installation, and evaluation of network or operating systems software (Microsoft, Linux desired), hardware...SeniorImmediate startRemote work
- ...Monitoring and analyzing security risks, the full-time remote Information Security Analyst II will perform threat detection, vulnerability management, and incident... ...in Information Security, Cybersecurity Operations, or Vulnerability Management Hands-on experience...OperationsFull timeRemote work
- ...Information Security Analyst As an Information Security Analyst in our vulnerability management team, you will ensure IT systems are operating in a secure manner in line with regulatory requirements. Join our vulnerability management team as an Information Security...OperationsRemote workWork from homeFlexible hours
- ...Information Security Analyst Reports To: Manager of Technology Operations & Security Employment Type: Full Time, FLSA Status: Exempt, EEO Category: Professionals The Impact You Will Have: The Information Security Analyst supports the company's day-to-day information...OperationsFull timeLocal areaRemote workFlexible hours
$75k - $95k
...Information Security Analyst Location: United States Job Type: Full-Time | Non-Exempt | Remote Eligible Salary Range: $75,000 – $95,000 per... ...audit experience in IT, information security, or security operations within a regulated environment, including FFIEC, FDIC, NACHA...OperationsFull timeLocal areaRemote workFlexible hours$75.2k - $158.1k
Job Title: Information System Security Officer (ISSO) / RMF AnalystJob... ...Department of Defense systems. As an Information... ...(ISSO) / RMF Analyst , you will manage the... ...requirements while supporting operational readiness and... ...path toward more senior Governance, Risk, and...OperationsFull timeContract workWork experience placementInterim roleLocal areaFlexible hours- Energage is seeking a Senior Security Analyst to advance information security, privacy, and compliance programs by implementing and continuously improving... ...role protects company systems, customer data, and operations while enabling growth. The position partners with Engineering...OperationsSeniorRemote job
- Great Southern Bank in Springfield, MO is seeking an Information Security Support Analyst II to join our security operations. The role collaborates with staff and management to sustain the Information Security Program and protect company information and infrastructure from...OperationsRemote work
$45 - $60 per hour
...3012652 Job Description: Position: Information Security Data Analyst Large Banking Client Location: Remote... ...processes to support secure business operations Support compliance with regulatory... ...in accordance with applicable law. Senior Level Mid‑Senior level Employment Type...OperationsFull timeContract workLocal areaRemote work- ...purpose has driven our scientific rigour, operational excellence, and deep therapeutic... ...highly regulated environment. As an Information Security Analyst, you'll play a hands‑on role in... ...people leaders in accordance with your seniority; social committee and several other...OperationsPermanent employmentFull timeSummer workWork at officeLocal areaRemote workFlexible hours
Do you want to receive more vacancies?
Subscribe and receive similar vacancies to Senior Principal Information Security Analyst, Defensive Operations. Be the first to apply!
- remote data analyst part time Remote
- senior data management analyst Remote
- neuroscience data analyst Remote
- data center analyst Remote
- oracle data analyst Remote
- senior financial data analyst Remote
- senior healthcare data analyst Remote
- provider data analyst Remote
- salesforce data analyst Remote
- data visualization analyst Remote




