Principal Scientist, Lab Head, Synthetic Immunity

The PositionThe OpportunityThe Department of Research Oncology at Genentech is excited to announce an opportunity for a Principal Scientist, Lab Head, to join the Synthetic Immunity division encompassing immune engager and CAR-T cell therapy programs. The position will lead a research group focused on developing next generation programs to advance Genentech’s Synthetic Immunity efforts.The ideal candidate will have a deep background in T cell immunology and/or cancer immunology. Extensive experience working with T cells in both in vitro and in vivo models is required. Deep knowledge of cellular immunology is strongly preferred.The successful candidate will lead a highly productive research team and integrate efforts across cross-functional teams to identify new targets and therapeutic hypotheses, and to advance transformative medicines using Synthetic Immunity approaches. Strong collaborative and excellent communication skills are essential.Key responsibilities include:Research Leadership: Lead and manage a high-performing team in the discovery and advancement of novel programs in Synthetic Immunity.Translational Impact: Generate high-quality, original research that advances our understanding of T cell biology and tumor immunology to contribute to the development of next generation Synthetic Immunity approaches.Communication and Collaboration: Work effectively in cross-functional teams by collaborating closely with colleagues from other Research departments, Drug Development, Translational Medicine and Early Clinical Development.Who You Are Educational Background: Ph.D. in Immunology, Cell Biology or other related fieldExperience: Minimum 5 years post-Ph.D. of productive postdoctoral training and/or industry experience. Your record should reflect high-impact publications, patents, and successful project transitions.Demonstrated expertise in T cell immunology, cellular immunology, and/or cancer immunology.Leadership and Collaboration: Exceptional leadership abilities with a proven track record of working with multidisciplinary teams, excellent written and verbal communication skills, and a collaborative spirit to work closely with cross-functional research teams.If you are passionate about harnessing the power of the immune system and Synthetic Immunity approaches to uncover and develop novel therapies for cancer, we encourage you to apply. PreferredExperience working with human and/or mouse T cells.Experience with engineering human T cells.Experience with syngeneic and/or xenograft in vivo modelsExperience with deep profiling of T and other immune cells (e.g. multiparameter flow, molecular profiling, etc.)Relocation benefits are available for this posting.The expected salary range for this position based on the primary location of California is $143,200 to $265,900. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.Benefits#LI-KC2#gREDGenentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.Job SummaryJob number: 202601-101383Date posted : 2026-07-27Profession: Research & DevelopmentEmployment type: Full time