Senior Scientist, NGS Profiling & Expression
$131.4k - $206.8kMSD Malaysia
- # Senior Scientist, NGS Profiling & ExpressionApplyremote type: Not Applicablelocations: USA - California - South San Francisco (Grand Ave)time type: Full timeposted on: Posted Todaytime left to apply: End Date: July 22, 2026 (13 days left to apply)job requisition id: R397087**Job Description**The Profiling & Expression department within Translational Medicine helps bridge Discovery and Development programs in multiple therapeutic areas through expertise in multimodal molecular analysis of tissues and model systems. We are a platform-based functional group leveraging a close partnership of pathologists, gene expression scientists, image analysis specialists, assay developers and data scientists to contribute to target validation, generation of quality mechanistic data, and the discovery and development of response and PD biomarkers with line of sight to the clinic. The Molecular Profiling group, within the Profiling & Expression department, provides key work for understanding: target tissue distributions in normal and diseased tissues, characterization of preclinical model systems, mechanism of action and proof of biology for candidate therapeutics, and drug response prediction.The Molecular Profiling Senior Scientist will work primarily with our research division's Discovery Oncology organization, providing targeted and NGS gene expression profiling support to reverse translation and preclinical target and biomarker validation efforts. Early discovery and pre-clinical work in support of other therapeutic areas will also be provided as needed. This high throughput lab requires an organized, highly motivated individual who can work collaboratively across multiple organizations in the development of therapeutic targets in the Discovery Portfolio.**Job responsibilities include the following:*** Provide insight and guidance to cross-functional collaborators regarding experimental design for gene expression-based work* Wet-lab support for project-based work including RNA isolation and gene expression profiling from bulk tissue, bulk sorted cell, and single cell populations* Present and lead discussions on experimental results and data interpretation at team and/or department meetings* Serve as Molecular Profiling representative to the Oncology translational research group as well as other program teams**QUALIFICATIONS:****Education:*** Bachelor's (with 7+ years), Master's (with 4+ years) or Ph.D. in biology, chemistry, biochemistry, molecular biology or related field and relevant experience**Required Experience and Skills:*** Experience with molecular biology techniques, including RNA/DNA isolation and NGS library preparation* Experience with targeted RT-qPCR and NGS platforms* Experience with multi-omics NGS platforms, low cell number sorted populations, and/or single-cell RNAseq* Experience in analysis of mid-density and/or whole transcriptomics gene expression data types* Prior experience in Oncology or Immunology* Strong interpersonal skills with an ability to contribute effectively in a team-based environment* Highly organized and able to manage time effectively* Ability to interface with translational, discovery, and clinical cross-functional colleagues to drive assay development and implementation into discovery and/or clinical programs as needed**Preferred Experience and Skills:*** Experience with RNA/DNA QC platforms such as the Qubit, Fragment Analyzer, Agilent Bioanalyzer or Tapestation* Experience with liquid automation for sample RNA/DNA isolation and NGS library prep* Experience with NGS analysis data visualization software such as Cell Ranger, Partek, OmniBrowser, or BioTuring* Familiarity with computer software: Illumina BaseSpace, Illumina Dragen, Spotfire, Graphpad Prism, Ingenuity Pathway Analysis* With management guidance, ability to incorporate innovative scientific and technical advances to support Profiling & Expression priorities #EligibleforERP **Required Skills:**DNA Isolation, Immunology, Molecular Biology, Next Generation Sequencing (NGS), Oncology, RNA Isolation, RNA Sequencing**Preferred Skills:**Current Employees apply HERECurrent Contingent Workers apply HERE**US and Puerto Rico Residents Only:**Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:EEOC Know Your RightsEEOC GINA SupplementWe are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.Learn more about your rights, including under California, Colorado and other US State ActsThe salary range for this role is$131,400.00 - $206,800.00This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at can apply for this role through (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.**San Francisco Residents Only:** We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance**Los Angeles Residents Only:** We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance**Search Firm Representatives Please Read Carefully** Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.**Employee Status:**Regular**Relocation:**Domestic**VISA Sponsorship:**No**Travel Requirements:**No Travel Required**Flexible Work Arrangements:**Not Applicable**Shift:**1st - Day**Valid Driving License:**No**Hazardous Material(s):**N/A**Job Posting End Date:**07/22/2026**\*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.**Our company is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where we have codified our legacy for over a century. Our success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.
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