Scientist - LC-MS/MS Bioanalytical

Career Category: Scientific Position Overview At Amgen, the mission is to serve patients living with serious illnesses. This Scientist LC‑MS/MS Bioanalytical role supports the design, development, validation, and implementation of robust quantitative LC‑MS/MS bioanalytical methods for small molecules and performs bioanalysis for discovery, GLP preclinical, and regulated clinical studies. The position is lab‑based and includes reviewing and interpreting scientific data, report generation, project management, and participation in multidisciplinary collaborations across research and development. Key Responsibilities Develop and implement LC‑MS/MS bioanalytical methods with quick turnaround times. Conduct small molecule bioanalysis of parent and metabolites in non‑clinical and clinical samples from various matrices (plasma, urine, CSF, tissues). Perform biological sample extraction using protein precipitation, SPE, and LLE. Generate complete, accurate, and concise documentation using LIMS and electronic laboratory notebook systems. Ensure bioanalytical data meets regulatory expectations for global submissions by maintaining accurate records and staying current with industry guidelines. Author study reports, SOPs, analytical methods, memos, scientific publications, and other regulatory‑compliant documents. Communicate bioanalytical data to key discovery and development teams, contribute to scientific publications, and present at professional meetings. Comply with safety guidelines and site‑specific procedures, including completion of training, maintenance of training records, laboratory documentation, and adherence to SOPs. Perform general laboratory housekeeping activities and operational support as needed. Basic Qualifications Doctorate degree (PhD, PharmD, or MD) with relevant post‑doctoral experience or Master’s degree and ≥3 years of LC‑MS/MS bioanalytical experience or Bachelor’s degree and ≥5 years of LC‑MS/MS bioanalytical experience. Preferred Qualifications Prior experience in pharma/biotech. Strong technical expertise in quantitative mass spectrometry on triple quadrupole (QQQ) platforms. Demonstrated expertise with diverse sample types (blood, plasma, tissues, urine, cerebrospinal fluid) and sample preparation techniques (SPE, LLE) for small molecules and metabolites by LC‑MS/MS. Experience with automation and/or micro‑sampling technologies. Prior GLP and GCP experience. Experience in regulated assay execution and method transfer to external contract laboratories. Understanding of pharmacokinetic and toxicokinetic principles and analysis. Willingness to work in a fast‑paced, multi‑project environment with high workload demands. Excellent scientific problem‑solving, project and time‑management, and stakeholder collaboration skills. Supervisory and mentoring experience in a lab‑based setting. Benefits Competitive base salary and annual bonus program. Health, dental, vision, life, and disability insurance; flexible spending accounts. Retirement and savings plans with generous company contributions. Stock‑based long‑term incentives. Comprehensive employee benefits package including time‑off plans. Flexible work models where possible. Career development opportunities. EEO Statement Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. Individuals with disabilities will be provided reasonable accommodation to participate in the job application or interview process and to perform essential job functions. #J-18808-Ljbffr Amgen Inc. (IR)