mRNA Immuno-Oncology Scientist

Our client, a leading organization in the biotechnology and vaccine development industry, is seeking a mRNA Immuno-Oncology Principal Scientist to join their team. As a Principal Scientist, you will be part of the Vaccine Research and Development department supporting innovative projects in cellular assay development. The ideal candidate will demonstrate strong leadership, analytical thinking, and collaborative skills, which will align successfully in the organization. Job Title: mRNA Immuno-Oncology Scientist Location: Cambridge, MA Pay Range: $75 Contract: 12 months to start, potential to extend What's the Job? Lead development of scalable, cell-based assay platforms for evaluating multi-epitope mRNA construct designs in a high-throughput environment. Provide technical leadership in flow cytometry and microscopy-based cellular readouts to optimize vaccine constructs. Collaborate with molecular biology and RNA teams to design experiments and interpret assay data for clear design recommendations. Establish and maintain robust workflows using cell lines ensuring assay reproducibility and operational compliance. Enable throughput-ready execution (96/384-well formats; standardized controls and analysis templates) Stay current with scientific advancements in RNA vaccines and contribute to internal reports and scientific publications. What's Needed? PhD in Molecular Biology, Cell Biology, Immunology, or related field with 3+ years of postdoctoral or industry experience, or MS with 8+ years of experience. Strong knowledge of molecular biology techniques, mRNA biology, and cancer vaccine principles. Hands‑on expertise in flow cytometry, including panel design, data analysis, and troubleshooting. Experience working with immune or engineered cell lines and microscopy-based cellular assays. Ability to develop high-throughput screening assays and operate liquid‑handling automation platforms is preferred. Experience with high-throughput screening of cellular assays (96/384-well), including assay miniaturization, robustness metrics, and automation-aware design. Hands‑on experience operating liquid‑handling platforms (e.g., Tecan, Hamilton) and/or partnering effectively with automation engineers. Familiarity with multiplex protein assays (e.g., bead‑based cytokine panels). Expertise developing and running T cell functional assays and translating results into actionable construct design decisions. Expertise in antigen processing and presentation pathways. Familiarity with immunopeptidomics. Working knowledge of data workflows for high-throughput biology (LIMS integration, assay metadata standards, reproducible analysis pipelines). Benefits Medical and Prescription Drug Plans Dental Plan Vision Plan Health Savings Account Health Flexible Spending Account Dependent Care Flexible Spending Account Supplemental Life Insurance Short Term and Long Term Disability Insurance Business Travel Insurance 401(k), Plus Match Weekly Pay #J-18808-Ljbffr ManpowerGroup Global, Inc.