Senior Separation Scientist

Yoh Life Sciences is hiring for a Sr. Separations Scientist in Bristol, PA. The individual will serve as a technical expert in separations-based characterization and method development across process development and CMC activities. The Sr. Separations Scientist will develop and implement advanced chromatographic workflows for structural characterization, impurity analysis, linker-payload assessment, DAR determination, and comparability studies to support clinical development programs. Position: Sr. Separations Scientist Duration: Contract to Perm Pay: $40-$50/hr DOE Shift: M-F 8-5pm Key Responsibilities Lead development, optimization, and transfer of chromatographic analytical methods supporting ADCs and related bioconjugate therapeutics. Design and execute chromatographic studies for characterization of intact proteins/antibodies, fragment antibodies, small format proteins, peptides, linker-payloads, oligonucleotides, and conjugated species. Perform characterization activities including DAR analysis, aggregation, fragmentation and charge variant assessment, free payload and linker impurity analysis, and stability studies. Support analytical investigations related to process development, manufacturing deviations, comparability, and product quality assessments. Collaborate closely with process development, bioassay, formulation, and quality teams to establish analytical control strategies and critical quality attributes (CQAs). Develop robust sample preparation workflows for proteins, peptides, oligonucleotides, and conjugated modalities for chromatographic analyses. Interpret complex analytical datasets and communicate findings to cross-functional project teams and client sponsors. Required Qualifications Ph.D. in Analytical Chemistry, Chemistry, Biochemistry, Pharmaceutical Sciences, or related discipline with 0 years of industry experience; M.S. with 2+ years or B.S. with 4+ years of relevant experience. Extensive hands-on experience with LCUV characterization of biologics, ADCs, or related conjugated therapeutics. Experience with analytical characterization techniques including RPLC/UV, SEC-UV, IEX-UV, non-reduced/reduced cIEF. Strong understanding of protein chemistry, conjugation technologies, and biopharmaceutical analytical development. Experience with data analysis software such as Waters Empower or equivalent platforms. Estimated Min Rate: $35.00 Estimated Max Rate: $50.00 What’s In It for You? We welcome you to be a part of the largest and legendary global staffing companies to meet your career aspirations. Yoh’s network of client companies has been employing professionals like you for over 65 years in the U.S., UK and Canada. Join Yoh’s extensive talent community that will provide you with access to Yoh’s vast network of opportunities and gain access to this exclusive opportunity available to you. Benefits include: Medical, Prescription, Dental & Vision Benefits (for employees working 20+ hours per week) Health Savings Account (HSA) (for employees working 20+ hours per week) Life & Disability Insurance (for employees working 20+ hours per week) MetLife Voluntary Benefits Employee Assistance Program (EAP) 401K Retirement Savings Plan Direct Deposit & weekly epayroll Referral Bonus Programs Certification and training opportunities Note: Any pay ranges displayed are estimations. Actual pay is determined by an applicant's experience, technical expertise, and other qualifications as listed in the job description. Yoh, a Day & Zimmermann company, is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran. Visit to contact us if you are an individual with a disability and require accommodation in the application process. For California applicants, qualified applicants with arrest or conviction records will be considered for employment in accordance with the Los Angeles County Fair Chance Ordinance for Employers and the California Fair Chance Act. All of the material job duties described in this posting are job duties for which a criminal history may have a direct, adverse, and negative relationship potentially resulting in the withdrawal of a conditional offer of employment. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability. By applying and submitting your resume, you authorize Yoh to review and reformat your resume to meet Yoh’s hiring clients’ preferences. 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