Global Development Product Lead (Sr Director)

Responsibilities Lead multiple (~1–3) cross‑functional oncology product teams from pre‑clinical candidate nomination (CAN) through Phase 1–2 clinical development and proof of concept (POC), with potential handoff to late‑stage Oncology Development (typically Phase 3). Collaborate with functional experts to integrate an end‑to‑end cross‑functional molecule strategy and risk mitigation plan; deliver data‑driven milestones via risk identification and mitigation. Support clinical trials and early‑development/lead‑development strategy across multiple Pfizer Oncology functions; represent the program with the external clinical community. Develop the clinical development plan from first‑in‑human through POC, including assessment of appropriate combinations and evaluation of predictive and pharmacodynamics biomarker plans. Ensure clinical plans include clinical expertise and medical monitoring of clinical trials. Lead, develop, and execute strategic development for early development assets; drive an integrated product plan addressing near‑term technical uncertainties and aligning with future pivotal development and commercialization. Ensure timely execution and delivery of product milestones within budget. Communicate with executive management and governance committees; provide clear product presentations and recommendations. Collaborate with partners on co‑development programs to deliver a shared global product strategy (when applicable). Set team objectives, prioritize tasks, and ensure adherence to the plan and strategy; proactively identify and resolve issues and develop contingency plans. Oversee early development assets’ development within indications (typically at least two clinical programs) and consult on multiple research projects. Work across multifunctional teams (Product Team, Global Development Team, Study team). Oversee development and management of clinical protocols/amendments, investigator brochures, clinical study reports, statistical analysis plans, and regulatory documents. Provide leadership to early‑stage clinical scientists in a matrix environment; work with cross‑functional colleagues to influence emerging targets, priorities, and program status. Implement PK‑guided dose escalation, early combination strategies, and innovations on first‑in‑human oncology trials. Oversee evaluation of safety, pharmacology, and efficacy data from ongoing/completed studies. Oversee manuscripts, abstracts, and presentations for scientific meetings/advisory boards; conduct literature reviews and prepare summaries. Serve as a medical resource for design and interpretation of clinical and preclinical programs. Coordinate regular interactions (at least quarterly and as needed) with clinical trials networks and KOL advisory boards to consider/implement feedback. Drive innovations in early clinical development, including translational oncology and precision medicine approaches. Translate early preclinical discovery into therapeutic candidates via cross‑functional collaboration. Coordinate with business development on strategic external collaborations and new research/program initiatives. Qualifications / Skills MD or MD‑PhD with 5+ years of industry experience (required). Oncology drug development experience; track record in oncology clinical research including early‑phase drug development (preferred). Clinical oncology experience; board certification in oncology (preferred). Significant industry leadership experience in clinical, translational, or basic research in biomedical sciences or drug‑development‑related disciplines. Knowledge of related disciplines (e.g., biostatistics, regulatory, pre‑clinical pharmacology, pharmaceutical sciences). Demonstrated scientific productivity (publications, abstracts, etc.). Proven scientific writing and strong communication skills. Proven leadership skills; ability to defend the clinical plan at governance meetings (essential). Ability to adapt to a fast‑paced, changing environment. Demonstrated effective leadership in cross‑functional and matrix teams; experience seeking and maintaining alignment with cross‑functional leaders. Passion for helping patients with cancer and for the science of oncology. Proactive, strategic, data‑driven decision‑making. Ability to focus and motivate a matrix organization with multiple stakeholders. Strong verbal, written, and presentation communication skills. Staff management and mentoring experience. Highly collaborative relationship‑building skills with internal leaders, external partners, and investigators/medical professionals. Strong leadership presence and ability to work effectively with other leaders. Team player in both leadership and contributor roles. Global perspective and ability to work across diverse cultures and geographies. #J-18808-Ljbffr