Senior Project Manager

SystImmune is a leading and well-funded clinical-stage biopharmaceutical company located in Bothell, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). SystImmune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials. SystImmune has a robust preclinical pipeline of potential cancer therapeutics in the discover and IND-enabling stages, representing cutting-edge biologics development. We offer an opportunity for you to learn and grow while making significant contributions to the company's success.


We are seeking a Senior Project Manager, R&D to support cross-functional planning and execution for oncology biologics programs from early discovery through IND-enabling activities and support of IND submission. This role will partner closely with Research, Translational Sciences, Nonclinical, Regulatory, Clinical Pharmacology, and external partners to drive integrated development strategy, stage-appropriate planning, risk management, and operational execution.

The ideal candidate brings strong biotech or biopharma drug development experience, excellent cross-functional leadership skills, and a deep understanding of the milestones, dependencies, and decision points required to advance innovative biologics programs into the clinic. This individual will serve as a strategic and operational hub for assigned programs, ensuring alignment, accountability, and timely progress across the portfolio. A key aspect of this role is the effective use of meeting management to strengthen stakeholder integration, communication, decision-making, and execution across internal and external teams.

This position is full-time onsite in Bothell, WA.

Key Responsibilities

• Lead cross-functional project planning and execution for oncology biologics programs spanning target/lead discovery, candidate selection, IND-enabling studies, CMC development, and IND submission
• Build, maintain, and drive integrated project plans, timelines, milestones, scenarios, and critical path analyses across multiple functional areas
• Partner with program leaders and functional heads to define development strategy, key objectives, deliverables, governance milestones, and resource assumptions
• Facilitate cross-functional team meetings, sub-team meetings, and governance reviews; document decisions, action items, risks, and next steps
• Identify interdependencies, operational risks, and potential bottlenecks early; drive mitigation plans and escalate issues appropriately
• Ensure alignment across Research, Nonclinical, CMC, Regulatory, Clinical, Biomarker/Translational, Quality, and partner organizations
• Drive program team preparedness for major stage gates, including candidate nomination, development candidate selection, IND-enabling study initiation, and IND submission
• Support budget planning, resource tracking, and external partner/CRO coordination as needed
• Develop concise and decision-oriented communications for senior leadership, governance bodies, and key stakeholders
• Track progress against program goals and proactively highlight deviations, tradeoffs, and decision needs
• Promote disciplined program management practices, clear accountability, and efficient team operations
• Contribute to portfolio planning and cross-program prioritization discussions where appropriate
• Help apply and improve R&D project management tools, templates, dashboards, and best practices
• Drive scalable adoption of AI-enabled and digital program management practices, including automation, dashboards, AI-assisted synthesis, standardized workflows, and data-driven reporting, to improve planning, meeting effectiveness, action tracking, knowledge management, risk identification, portfolio governance, and cross-functional execution while ensuring human oversight, data integrity, and compliance.

Required Qualifications

• Bachelor's degree in life sciences, biomedical sciences, chemistry, engineering, or related field
• 8+ years of relevant experience in biotech, biopharma, or related life sciences industry
• 5+ years of project or program management experience supporting drug discovery and/or development programs
• Demonstrated experience managing biologics programs in oncology or closely related therapeutic areas
• Strong understanding of drug development from discovery through IND, including:
  • discovery research and candidate selection
  • IND-enabling toxicology and pharmacology
  • CMC and analytical development for biologics
  • regulatory documentation and IND submission processes
• Proven ability to lead highly matrixed, cross-functional teams without direct authority
• Excellent communication, facilitation, organizational, and stakeholder management skills
• Strong problem-solving abilities with demonstrated experience managing complex timelines, dependencies, and risks
• Experience preparing executive-level presentations, status reports, and governance materials

Preferred Qualifications

• Advanced degree (MS, PhD, PharmD, or MBA) in a relevant scientific or business discipline
• Experience with monoclonal antibodies, bispecifics, ADCs, or other complex biologic modalities in oncology
• Mandarin-English Bilingual Ability
• PMP or related project management certification is a plus and biotherapeutics life cycles
• Experience in a fast-paced, innovation-driven biotech environment

Core Competencies

• Strategic thinking with strong operational execution
• Cross-functional leadership and influence
• Decision facilitation and issue resolution
• Planning discipline and attention to detail
• Agility in a dynamic R&D environment
• Strong sense of ownership and accountability

Success in this role will be defined by the ability to:

• keep complex oncology biologics programs aligned and moving forward from discovery to IND
• create clarity across scientific and development teams around priorities, timelines, and decisions
• anticipate risks and dependencies before they become delays
• enable efficient governance and high-quality decision-making
• build trust across functions as a strategic and operational partner

Position Type/Expected Hours of Work

• May need to work outside of standard working hours at times
• This role is currently working onsite and is expected to work onsite for working hours, with flexibility to work start time. The work location for this role is in Bothell, WA.

Compensation and Benefits:
The expected base salary range for this position is $100,000 - $160,000 annually. Actual compensation will be based on a variety of factors, including but not limited to a candidate's qualifications, experience, and skills.
While most offers typically fall within the low to mid-point of the range, we may extend an offer toward the higher end for exceptional candidates whose background and expertise exceeds the requirements of the role.


SystImmune is a leading and well-funded biotech company with a bright future. We offer an opportunity for you to learn and grow while making significant contributions to the company's success. SystImmune offers a comprehensive benefits package including: 100% paid employee premiums for medical/dental/vision, also STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years, 15 PTO days per year, sick leave, plus 11 paid holidays and MORE.


We offer an opportunity for you to learn and grow while making significant contributions to the company's success.


SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.