Principal Cloud Engineer, Infrastructure | Onsite San Diego HQ

Who We Are: Neurocrine Biosciences is a leading biopharmaceutical company dedicated to discovering, developing, and commercializing life‑changing treatments for patients with under‑addressed neurological, psychiatric, endocrine, and immunological disorders. The company focuses on addressing complex conditions and advancing therapeutic areas with multiple FDA‑approved treatments and a robust pipeline of mid‑to‑late phase clinical candidates. About the Role: The Principal Cloud and Infrastructure Engineer is a senior technical expert responsible for designing, modernizing, and optimizing enterprise‑scale hybrid cloud environments across Azure, AWS, and on‑prem infrastructure. The role leads cloud transformation initiatives—migration, automation, infrastructure modernization, FinOps optimization, and secure platform engineering—while establishing architectural standards for scalability, reliability, compliance, and operational excellence. Responsibilities: Cloud Architecture & Infrastructure Modernization Lead enterprise‑scale cloud transformation initiatives, including infrastructure consolidation, virtualization, hybrid cloud modernization, and migration strategies across Azure, AWS, and on‑prem environments. Architect scalable, resilient, and highly available cloud infrastructure solutions aligned with business, security, and compliance requirements. Design and implement hybrid connectivity architectures leveraging Azure ExpressRoute, VPN, SD‑WAN, private endpoints, and secure access technologies. Develop disaster recovery, business continuity, and high‑availability strategies across cloud and datacenter platforms. Platform Engineering & Automation Champion automation‑first engineering practices using Infrastructure as Code (IaC) technologies including Terraform, ARM/Bicep, and CloudFormation. Design and implement API‑driven, self‑service infrastructure provisioning platforms integrated with ServiceNow, identity platforms, and CI/CD pipelines. Standardize and automate infrastructure deployment, configuration management, patching, monitoring, and lifecycle operations. Lead adoption of modern platform engineering practices supporting scalable and repeatable infrastructure delivery. Cloud Operations, Optimization & FinOps Lead cloud governance, cost optimization, and FinOps initiatives across Azure and AWS environments, including consumption analysis, reserved instance strategies, rightsizing, and budgeting controls. Establish operational standards for monitoring, observability, performance tuning, and incident response across hybrid infrastructure. Optimize storage and compute utilization through lifecycle management, automated tiering, and workload balancing strategies. Drive continuous improvement initiatives to enhance reliability, scalability, operational efficiency, and service performance. Compute, Storage & Virtualization Architect and optimize VMware infrastructure platforms with a focus on footprint reduction, operational efficiency, resiliency, and automation. Design scalable enterprise storage solutions across Azure, AWS (S3, FSx), and NetApp environments, including backup, replication, and lifecycle governance. Enable secure, scalable compute platforms supporting containerized workloads, Kubernetes orchestration, analytics platforms, and modern application hosting requirements. Security & Identity Integration Implement identity‑driven access models using Active Directory, Azure AD/Entra ID, RBAC, and policy‑based provisioning frameworks. Integrate security best practices into all cloud and infrastructure architectures, including zero‑trust principles, segmentation, encryption, and secure access controls. Ensure compliance with enterprise security, audit, and regulatory standards across cloud and on‑prem environments. Collaborate with cybersecurity teams to implement governance policies, risk mitigation controls, and infrastructure hardening standards. Leadership & Cross‑Functional Collaboration Provide technical leadership, mentorship, and strategic guidance to cloud and infrastructure engineering teams. Partner with application, security, networking, and enterprise architecture teams to deliver scalable cloud solutions aligned with organizational goals. Serve as a subject‑matter expert for cloud architecture, hybrid infrastructure, automation, and platform engineering initiatives. Evaluate emerging technologies, industry trends, and Microsoft Azure innovations to recommend and drive modernization and continuous improvement. Requirements: High School Diploma, GED, or equivalent and 10+ years of equivalent experience, training, or certifications; or bachelor's degree and 6+ years of hybrid technology infrastructure engineering experience with 4+ years focused on Azure services; or master's degree and 4+ years of relevant experience. Experience managing enterprise hybrid infrastructure environments across on‑premises, Azure, and multi‑cloud platforms, including support for scientific and high‑performance computing workloads. Deep expertise in Microsoft Azure cloud services, including Entra ID, Virtual Desktop Infrastructure (VDI), Storage, SQL, networking, governance, and security services. Strong proficiency with Infrastructure as Code (IaC) and automation frameworks such as Terraform, ARM/Bicep, and CloudFormation. Advanced knowledge of hybrid cloud architecture, infrastructure integration, and enterprise platform modernization strategies. Proven experience designing, deploying, and optimizing scalable HPC and analytics platforms in cloud and hybrid environments. Hands‑on experience with enterprise storage architectures across Azure and on‑premises platforms, including performance optimization, lifecycle management, and data protection strategies. Familiarity with scientific computing applications, research platforms, and data‑intensive workloads in regulated environments. Strong understanding of datacenter operations, virtualization technologies (VMware), backup/recovery, and infrastructure resiliency practices. Experience implementing cloud security best practices, identity and access management, governance controls, and compliance standards across hybrid environments. Demonstrated leadership, communication, and cross‑functional collaboration skills with experience mentoring engineers and partnering with technical and business stakeholders. Ability to work as part of a team; may train lower levels. Strong project management skills. Benefits & Compensation: Annual base salary range: $132,700.00 – $182,000.00. Annual bonus target: 30% of earned base salary. Eligibility to participate in equity‑based long‑term incentive program. Retirement savings plan with company match. Paid vacation, holiday, and personal days. Paid caregiver/parental and medical leave. Health benefits including medical, prescription drug, dental, and vision coverage. Neurocrine Biosciences is an EEO/Disability/Vets employer. We are committed to building a workplace of belonging, respect, and empowerment, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don’t line up to exactly what we have outlined in the job description. #J-18808-Ljbffr