Senior Director, AIRx Biochemistry - In Vitro Biology Lead

Job Description Takeda Research is constructing a Lab of Tomorrow built on AI, automation, new ways of working, and talent with the singular vision of delivering differentiated medicines to the clinic at speed and cost. To catalyze these efforts, Takeda is creating two complementary units: AI Research Accelerator (AIRx) and Discovery Automation & Robotics (DAR). AIRx will consist of a dedicated group of experienced drug hunters with the autonomy of a biotech and the resources of a leading pharmaceutical company. It is designed to incubate the future AI‑powered operating models and deliver candidates to the clinic at industry leading speed and success rates. Purpose The Biochemist owns the in‑vitro pharmacology cascade for all AIRx programs. This scientist defines the testing strategy, oversees externalized assay execution through CRO partners, and ensures all biochemical and cellular data generated is high‑quality, reproducible, and directly informing go/no‑go decisions. This role operates at the intersection of classical pharmacology and AI‑enabled data analysis — integrating experimental outputs into the AIRx DMTA loop and contributing to the broader data infrastructure that powers AI‑enabled insights generation. Accountabilities Design and own the in‑vitro pharmacology cascade for all AIRx programs across both project teams Define CRO assay specifications; provide scientific oversight of externalized assay execution; critically interpret biochemical and cellular data packages Integrate biochemical data into AI‑enabled DMTA cycles; partner with Computational and Medicinal Chemistry to close design loops rapidly Ensure data quality, reproducibility, and standardization across external biology partners; leverage SAIL and Aedifica Fortis platforms for data ingestion and analysis Contribute to safety, selectivity, and mechanistic profiling strategies in coordination with internal Safety and DMPK contacts Provide scientific input to PRC presentations and governance decision‑making forums Contribute to harmonization of assay data across sources to support AI model training and insights generation Maintain awareness of relevant biochemistry literature and emerging assay technologies to continuously improve the testing cascade Qualifications & Competencies PhD in biochemistry, pharmacology, or cell biology 12‑15+ years of drug discovery experience with hands‑on expertise in biochemical and cell‑based assay development and interpretation Proven track record designing and managing externalized CRO biochemistry and pharmacology programs Ability to critically evaluate and integrate large in‑vitro datasets from multiple external sources Experience in at least one therapeutic area represented across the Takeda Research portfolio Experience with AI/ML data analysis platforms preferred (e.g., automated data pipelines, TetraScience) Background in mechanistic and MoA‑level characterization alongside standard binding/enzyme/cell assays Strong cross‑functional collaboration skills; able to work at pace in a lean team environment Additional Information The position will be based in Cambridge, MA. This position is currently classified as “hybrid” by Takeda’s Hybrid and Remote Work policy. Compensation and Benefits Summary U.S. Base Salary Range: $212,000.00 – $333,190.00. U.S. based employees may be eligible for short‑term and/or long‑term incentives, medical, dental, vision, 401(k) plan with company match, short‑term and long‑term disability coverage, basic life insurance, tuition reimbursement, paid volunteer time off, company holidays, well‑being benefits, and up to 80 hours of sick time. New hires can accrue up to 120 hours of paid vacation. EEO Statement Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law. Locations Boston, MA Worker Type Employee Worker Sub‑Type Regular Time Type Full time Job Exempt Yes #J-18808-Ljbffr Takeda