The Mayo Clinic Program in Precision Genomics: Interventional Therapeutics

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Program Overview Mayo Clinic and its Department of Clinical Genomics, as well as other aligned Departments and Programs, are seeking exceptional physicians and scientists, experts in the rapidly evolving field of genome editing and therapeutic delivery, to drive innovation at the intersection of discovery, translational, clinical research, and clinical practice to join our new and rapidly evolving Program in Precision Genomics: Interventional Therapeutics (PG‑IT). The PG‑IT program at Mayo Clinic is a groundbreaking new initiative of highly innovative and creative scientists and physicians working collaboratively to advance next‑generation molecular therapies by delivering genetically targeted treatments in vivo. We are building an accomplished team of leaders including scientists driving innovation in genome editing and physicians who can deliver customized new and novel genetic therapies to the patients we serve. Program Strengths The Mayo Clinic Artificial Intelligence Program, driving the development of AI‑based drug discovery, predictive models, large language models, and AI agents within research and implemented into the Mayo Clinic clinical practice. Mayo Clinic Platform, the world’s largest distributed federated healthcare data network with cloud‑based storage of fully digitized longitudinal patient records and associated research data and biospecimens from >50M patients. Exceptional research and clinical programs, research infrastructure, shared research resources, and education and training programs to facilitate research in basic and clinical genomics and molecular engineering. A robust clinical research and clinical trials infrastructure that currently supports the delivery of the nation’s largest number of clinical trials to the patients we serve, including new and novel and “first in human” therapies, including cellular, biologic, and genetic therapies. Mayo Clinic’s unique collaborative ecosystem, which includes an integrated clinical practice, world‑class research platforms, and advanced infrastructure for gene and cell‑based therapeutic development. Program Goals Our goals for the PG‑IT program include in‑vivo human gene editing for rare and inherited genetic disorders and complex human diseases, the acceleration of drug repurposing for genetically targeted indications, and identifying the most promising novel gene‑editing interventions to benefit patients. These goals span therapeutic development, CRISPR‑ and RNA‑based interventions, genome engineering, molecular diagnostics, novel mechanisms and modes of delivery of genetic therapies in vivo, and the deployment of genomics‑enabled clinical care pathways for rare, inherited, and complex conditions. Success Profile Successful candidates will lead, design, and implement innovative genomic and translational approaches that improve patient outcomes while driving forward to the next generation of therapeutic and diagnostic discovery. Faculty will contribute to the development and integration of emerging genomic technologies into clinical and therapeutic pipelines, helping to shape programs that influence local, national, and global practice in genomic medicine. The Department of Clinical Genomics The Department of Clinical Genomics at Mayo Clinic is a national leader in integrating advanced genomic science with patient‑centered clinical care. Our mission is to individualize medicine through the development and application of cutting‑edge genomic technologies that enable the prediction, prevention, diagnosis, and treatment of both rare and common genetic conditions. By generating deep insights into each patient’s genomic architecture, our teams drive innovative care strategies that improve outcomes and shape the future of precision medicine. Clinical Genomics supports a broad spectrum of services, including comprehensive family history assessments, risk evaluations for hereditary conditions, and whole‑exome, whole‑genome, and multi‑omic testing for complex and rare disorders. The department operates through a highly collaborative, multidisciplinary model, bringing together medical geneticists, PhD scientists, certified genetic counselors, nurses, and allied specialists across Mayo Clinic’s practice and research environment. Recruitment of Basic and Translational Discovery Scientists in Gene Editing PhD or equivalent degree with post‑doctoral training in relevant scientific fields. Demonstrated expertise in genetics and genomics in human cells and tissues and/or in relevant model systems. Experience in developing or applying human and other model systems or disease‑specific cellular platforms. Proven record of scholarly productivity, including high quality peer‑reviewed publications and peer‑reviewed funding and/or industry funding (or clear potential to gain future funding) leading to impactful research contributions. Demonstrated creativity and innovation. Ability to contribute to translational genomics programs that integrate discovery science with clinical or therapeutic applications. Strong communication skills with the ability to collaborate across scientific, clinical, and operational teams. Commitment to Mayo Clinic’s values including teamwork, integrity, innovation, and patient‑centered care. Clinician Investigators in In‑Vivo Gene Editing and Therapeutic Delivery Board‑certified MD, MD/PhD, or equivalent clinical degree with experience in clinical genetics and/or genomics. Expertise in multiple human gene‑editing or therapeutic genomics modalities and in in‑vivo therapeutic delivery. Proven record of scholarly productivity, including high quality peer‑reviewed publications and sustained peer‑reviewed funding and/or industry funding leading to impactful research contributions. Demonstrated creativity and innovation. Proven track record in innovative translational and clinical research including novel therapeutics and therapeutic development and in the design and conduct of human clinical trials, particularly early phase and first‑in‑human human clinical trials and single patient INDs. Demonstrated academic leadership in research and clinical practice and program‑building expertise. Demonstrated ability to develop strategies and drive multidisciplinary teams to success. Preferred Qualifications Experience working in collaborative, multidisciplinary research or clinical environments. Experience in teaching and mentoring. Experience participating in multi‑institutional research networks or other large, collaborative scientific initiatives. #J-18808-Ljbffr